Effectiveness and safety of combined antiplatelet and anticoagulant therapy: A critical review of the evidence from randomized controlled trials

Blood Reviews ◽  
2011 ◽  
Vol 25 (3) ◽  
pp. 123-129 ◽  
Author(s):  
Jeremy S. Paikin ◽  
Doug S. Wright ◽  
John W. Eikelboom
Keyword(s):  
Randomized Controlled Trials ◽  
Anticoagulant Therapy ◽  
Critical Review ◽  
Controlled Trials ◽  
Randomized Controlled

scholarly journals Neurorehabilitation in Parkinson’s Disease: A Critical Review of Cognitive Rehabilitation Effects on Cognition and Brain

2018 ◽  
Vol 2018 ◽  
pp. 1-12 ◽  
Author(s):  
María Díez-Cirarda ◽  
Naroa Ibarretxe-Bilbao ◽  
Javier Peña ◽  
Natalia Ojeda
Keyword(s):  
Quality Of Life ◽  
Parkinson’S Disease ◽  
Randomized Controlled Trials ◽  
Critical Review ◽  
Cognitive Rehabilitation ◽  
Controlled Trials ◽  
Randomized Controlled ◽  
Brain Changes

Background. Parkinson’s disease (PD) patients experience cognitive impairment which has been related to reduced quality of life and functional disability. These symptoms usually progress until dementia occurs. Some studies have been published assessing the efficacy of cognitive treatments on improving cognition, functional outcome, and producing changes in brain activity. Objective. A critical review was performed to present up-to-date neurorehabilitation effects of cognitive rehabilitation in PD, with special emphasis on the efficacy on cognition, quality of life aspects, brain changes, and the longitudinal maintenance of these changes. Results. After exclusions, 13 studies were reviewed, including 6 randomized controlled trials for the efficacy on cognition, 2 randomized controlled trials regarding the brain changes after cognitive training, and 5 studies which evaluated the long-term effects of cognitive treatments. Conclusions. Cognitive rehabilitation programs have demonstrated to be effective on improving cognitive functions, but more research is needed focusing on the efficacy on improving behavioral aspects and producing brain changes in patients with PD. Moreover, there is a need of randomized controlled trials with long-term follow-up periods.

Sign in / Sign up

Export Citation Format

Share Document