Synthesis and biological evaluation of a small molecule library of 3rd generation multidrug resistance modulators

2009 ◽  
Vol 17 (6) ◽  
pp. 2524-2535 ◽  
Author(s):  
Werner Klinkhammer ◽  
Henrik Müller ◽  
Christoph Globisch ◽  
Ilza K. Pajeva ◽  
Michael Wiese
Keyword(s):  
Multidrug Resistance ◽  
Small Molecule ◽  
Biological Evaluation ◽  
Small Molecule Library ◽  
Synthesis And Biological Evaluation ◽  
Resistance Modulators

scholarly journals LB794 Synthesis and biological evaluation of a small molecule library identifies novel anti-skin cancer agents

2021 ◽  
Vol 141 (9) ◽  
pp. B19
Author(s):  
S.T. Boateng ◽  
T. Roy ◽  
R.N. Chamcheu ◽  
S. Banang-Mbeumi ◽  
A.L. WALKER ◽  
...  
Keyword(s):  
Skin Cancer ◽  
Small Molecule ◽  
Biological Evaluation ◽  
Small Molecule Library ◽  
Synthesis And Biological Evaluation

Design, synthesis and biological evaluation of stereo- and regioisomers of amino aryl esters as multidrug resistance (MDR) reversers

2019 ◽  
Vol 182 ◽  
pp. 111655 ◽  
Author(s):  
Elisabetta Teodori ◽  
Marialessandra Contino ◽  
Chiara Riganti ◽  
Gianluca Bartolucci ◽  
Laura Braconi ◽  
...  
Keyword(s):  
Multidrug Resistance ◽  
Biological Evaluation ◽  
Design Synthesis ◽  
Synthesis And Biological Evaluation

Discovery to solve multidrug resistance: Design, synthesis, and biological evaluation of novel agents

2019 ◽  
Vol 352 (10) ◽  
pp. 1900127 ◽  
Author(s):  
Qianqian Qiu ◽  
Wei Shi ◽  
Shiyuan Zhao ◽  
Yan Zhu ◽  
Zhengquan Ding ◽  
...  
Keyword(s):  
Multidrug Resistance ◽  
Biological Evaluation ◽  
Novel Agents ◽  
Design Synthesis ◽  
Synthesis And Biological Evaluation

scholarly journals Small-Molecule Inhibitors of 25-Hydroxyvitamin D-24-Hydroxylase (CYP24A1): Synthesis and Biological Evaluation

2014 ◽  
Vol 57 (18) ◽  
pp. 7702-7715 ◽  
Author(s):  
Salvatore Ferla ◽  
Ahmed S. Aboraia ◽  
Andrea Brancale ◽  
Christopher J. Pepper ◽  
Jinge Zhu ◽  
...  
Keyword(s):  
Small Molecule ◽  
Small Molecule Inhibitors ◽  
Biological Evaluation ◽  
Hydroxyvitamin D ◽  
25 Hydroxyvitamin D ◽  
Synthesis And Biological Evaluation

Design, synthesis and biological evaluation of novel triazole-core reversal agents against P-glycoprotein-mediated multidrug resistance

RSC Advances ◽  
2016 ◽  
Vol 6 (31) ◽  
pp. 25819-25828 ◽  
Author(s):  
Bo Zhang ◽  
Tianxiao Zhao ◽  
Jie Zhou ◽  
Qianqian Qiu ◽  
Yuxuan Dai ◽  
...  
Keyword(s):  
Multidrug Resistance ◽  
Click Chemistry ◽  
Biological Evaluation ◽  
Glycoprotein P ◽  
Design Synthesis ◽  
Reversal Agents ◽  
P Glycoprotein ◽  
Synthesis And Biological Evaluation

We designed and synthesized a novel series of P-glycoprotein (P-gp)-mediated multidrug resistance (MDR) inhibitors bearing a triazolphenethyl–tetrahydroisoquinoline scaffold through click chemistry.

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