Design, synthesis, biological evaluation and molecular modelling studies of novel quinoline derivatives against Mycobacterium tuberculosis

2009 ◽  
Vol 17 (7) ◽  
pp. 2830-2841 ◽  
Author(s):  
Ram Shankar Upadhayaya ◽  
Jaya Kishore Vandavasi ◽  
Nageswara Rao Vasireddy ◽  
Vivek Sharma ◽  
Shailesh S. Dixit ◽  
...  
Keyword(s):  
Mycobacterium Tuberculosis ◽  
Molecular Modelling ◽  
Biological Evaluation ◽  
Quinoline Derivatives ◽  
Design Synthesis ◽  
Molecular Modelling Studies ◽  
Modelling Studies

Design, synthesis, biological evaluation and molecular modelling studies of conophylline inspired novel indolyl oxoacetamides as potent pancreatic lipase inhibitors

2020 ◽  
Vol 44 (28) ◽  
pp. 12355-12369
Author(s):  
Sridhar S. N. C. ◽  
Saksham Palawat ◽  
Atish T. Paul
Keyword(s):  
Pancreatic Lipase ◽  
Molecular Modelling ◽  
Biological Evaluation ◽  
Design Synthesis ◽  
Molecular Modelling Studies ◽  
Modelling Studies ◽  
Pancreatic Lipase Inhibitors ◽  
Pancreatic Lipase Inhibition ◽  
Lipase Inhibition

Twenty-one indolyl oxoacetamides were designed and synthesized inspired by conophylline. Analogues 12c and 12b with N-geranyl substitution on indole exhibited potent pancreatic lipase inhibition.

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