Synthesis and biological evaluation of phenolic 4,5-dihydroisoxazoles and 3-hydroxy ketones as estrogen receptor α and β agonists

Pekka K. Poutiainen; Tuomas A. Venäläinen; Mikael Peräkylä; Juha M. Matilainen; Sami Väisänen; Paavo Honkakoski; Reino Laatikainen; Juha T. Pulkkinen

doi:10.1016/j.bmc.2010.04.007

Synthesis and biological evaluation of phenolic 4,5-dihydroisoxazoles and 3-hydroxy ketones as estrogen receptor α and β agonists

Bioorganic & Medicinal Chemistry ◽

10.1016/j.bmc.2010.04.007 ◽

2010 ◽

Vol 18 (10) ◽

pp. 3437-3447 ◽

Cited By ~ 23

Author(s):

Pekka K. Poutiainen ◽

Tuomas A. Venäläinen ◽

Mikael Peräkylä ◽

Juha M. Matilainen ◽

Sami Väisänen ◽

...

Keyword(s):

Estrogen Receptor ◽

Estrogen Receptor Α ◽

Biological Evaluation ◽

Hydroxy Ketones ◽

Synthesis And Biological Evaluation

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Molecular design, chemical synthesis, and biological evaluation of agents that selectively photo-degrade the transcription factor estrogen receptor-α

Organic & Biomolecular Chemistry ◽

10.1039/c1ob05629h ◽

2011 ◽

Vol 9 (18) ◽

pp. 6357 ◽

Cited By ~ 9

Author(s):

Kana Tsumura ◽

Akane Suzuki ◽

Takeo Tsuzuki ◽

Shuho Tanimoto ◽

Hajime Kaneko ◽

...

Keyword(s):

Estrogen Receptor ◽

Transcription Factor ◽

Chemical Synthesis ◽

Molecular Design ◽

Estrogen Receptor Α ◽

Biological Evaluation ◽

Synthesis And Biological Evaluation

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Design, synthesis and biological evaluation of novel dual-acting modulators targeting both estrogen receptor α (ERα) and lysine-specific demethylase 1 (LSD1) for treatment of breast cancer

European Journal of Medicinal Chemistry ◽

10.1016/j.ejmech.2020.112281 ◽

2020 ◽

Vol 195 ◽

pp. 112281

Author(s):

Ming He ◽

Wentao Ning ◽

Zhiye Hu ◽

Jian Huang ◽

Chune Dong ◽

...

Keyword(s):

Breast Cancer ◽

Estrogen Receptor ◽

Estrogen Receptor Α ◽

Biological Evaluation ◽

Design Synthesis ◽

Lysine Specific Demethylase ◽

Synthesis And Biological Evaluation

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Synthesis and biological evaluation of a fluorine-18 labeled estrogen receptor-α selective ligand: [18F] propyl pyrazole triol

Nuclear Medicine and Biology ◽

10.1016/s0969-8051(02)00446-8 ◽

2003 ◽

Vol 30 (4) ◽

pp. 397-404 ◽

Cited By ~ 8

Author(s):

Dange Vijaykumar ◽

Mohammed H. Al-Qahtani ◽

Michael J. Welch ◽

John A. Katzenellenbogen

Keyword(s):

Estrogen Receptor ◽

Estrogen Receptor Α ◽

Biological Evaluation ◽

Selective Ligand ◽

Synthesis And Biological Evaluation

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Synthesis and Biological Evaluation of a Novel Series of Furans: Ligands Selective for Estrogen Receptor α

Journal of Medicinal Chemistry ◽

10.1021/jm010211u ◽

2001 ◽

Vol 44 (23) ◽

pp. 3838-3848 ◽

Cited By ~ 174

Author(s):

Deborah S. Mortensen ◽

Alice L. Rodriguez ◽

Kathryn E. Carlson ◽

Jun Sun ◽

Benita S. Katzenellenbogen ◽

...

Keyword(s):

Estrogen Receptor ◽

Estrogen Receptor Α ◽

Biological Evaluation ◽

Synthesis And Biological Evaluation

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Structure-based drug design, synthesis, In vitro, and In vivo biological evaluation of indole-based biomimetic analogs targeting estrogen receptor-α inhibition

European Journal of Medicinal Chemistry ◽

10.1016/j.ejmech.2019.01.068 ◽

2019 ◽

Vol 166 ◽

pp. 281-290 ◽

Cited By ~ 6

Author(s):

Moataz S. Hendy ◽

Aya A. Ali ◽

Lubna Ahmed ◽

Reham Hossam ◽

Alaa Mostafa ◽

...

Keyword(s):

Estrogen Receptor ◽

Drug Design ◽

Estrogen Receptor Α ◽

Biological Evaluation ◽

Structure Based Drug Design ◽

Design Synthesis

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Synthesis and biological evaluation of novel cyclopropyl derivatives as subtype-selective ligands for estrogen receptor

Journal of Pharmacy and Pharmacology ◽

10.1111/jphp.12908 ◽

2018 ◽

Vol 70 (7) ◽

pp. 910-918 ◽

Cited By ~ 2

Author(s):

Zunyuan Wang ◽

Yewei Yang ◽

Xiaoliang Zheng ◽

Tao Zhang ◽

Wenhai Huang ◽

...

Keyword(s):

Estrogen Receptor ◽

Biological Evaluation ◽

Selective Ligands ◽

Subtype Selective ◽

Synthesis And Biological Evaluation

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Synthesis and biological evaluation of novel m-carborane-containing estrogen receptor partial agonists as SERM candidates

Bioorganic & Medicinal Chemistry Letters ◽

10.1016/j.bmcl.2015.05.083 ◽

2015 ◽

Vol 25 (16) ◽

pp. 3213-3216 ◽

Cited By ~ 8

Author(s):

Kiminori Ohta ◽

Takumi Ogawa ◽

Asako Kaise ◽

Yasuyuki Endo

Keyword(s):

Estrogen Receptor ◽

Biological Evaluation ◽

Partial Agonists ◽

Synthesis And Biological Evaluation

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Synthesis and biological evaluation of guanylhydrazone coactivator binding inhibitors for the estrogen receptor

Bioorganic & Medicinal Chemistry ◽

10.1016/j.bmc.2008.10.007 ◽

2008 ◽

Vol 16 (23) ◽

pp. 10075-10084 ◽

Cited By ~ 44

Author(s):

Andrew L. LaFrate ◽

Jillian R. Gunther ◽

Kathryn E. Carlson ◽

John A. Katzenellenbogen

Keyword(s):

Estrogen Receptor ◽

Biological Evaluation ◽

Coactivator Binding Inhibitors ◽

Synthesis And Biological Evaluation ◽

Binding Inhibitors

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Estrogen Receptor Dependent Inhibitors of NF-κB Transcriptional Activation-1 Synthesis and Biological Evaluation of Substituted 2-Cyanopropanoic Acid Derivatives: Pathway Selective Inhibitors of NF-κB, a Potential Treatment for Rheumatoid Arthritis

Journal of Medicinal Chemistry ◽

10.1021/jm701013k ◽

2007 ◽

Vol 50 (22) ◽

pp. 5245-5248 ◽

Cited By ~ 8

Author(s):

Thomas J. Caggiano ◽

Antony Brazzale ◽

Douglas M. Ho ◽

Christina M. Kraml ◽

Eugene Trybulski ◽

...

Keyword(s):

Rheumatoid Arthritis ◽

Estrogen Receptor ◽

Transcriptional Activation ◽

Biological Evaluation ◽

Potential Treatment ◽

Selective Inhibitors ◽

Synthesis And Biological Evaluation

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Design, synthesis and biological evaluation of novel indole-benzimidazole hybrids targeting estrogen receptor alpha (ER-α)

European Journal of Medicinal Chemistry ◽

10.1016/j.ejmech.2018.01.051 ◽

2018 ◽

Vol 146 ◽

pp. 206-219 ◽

Cited By ~ 13

Author(s):

Ramit Singla ◽

Kunj Bihari Gupta ◽

Shishir Upadhyay ◽

Monisha Dhiman ◽

Vikas Jaitak

Keyword(s):

Estrogen Receptor ◽

Estrogen Receptor Alpha ◽

Biological Evaluation ◽

Design Synthesis ◽

Receptor Alpha ◽

Synthesis And Biological Evaluation

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