Design, synthesis and biological evaluation of novel dual-acting modulators targeting both estrogen receptor α (ERα) and lysine-specific demethylase 1 (LSD1) for treatment of breast cancer

2020 ◽  
Vol 195 ◽  
pp. 112281
Author(s):  
Ming He ◽  
Wentao Ning ◽  
Zhiye Hu ◽  
Jian Huang ◽  
Chune Dong ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Estrogen Receptor ◽  
Estrogen Receptor Α ◽  
Biological Evaluation ◽  
Design Synthesis ◽  
Lysine Specific Demethylase ◽  
Synthesis And Biological Evaluation

scholarly journals Design, synthesis, and biological evaluation of new 6,N2-diaryl-1,3,5-triazine-2,4-diamines as anticancer agents selectively targeting triple negative breast cancer cells

RSC Advances ◽  
2020 ◽  
Vol 10 (43) ◽  
pp. 25517-25528
Author(s):  
Ahmad Junaid ◽  
Felicia Phei Lin Lim ◽  
Edward R. T. Tiekink ◽  
Anton V. Dolzhenko
Keyword(s):  
Breast Cancer ◽  
Triple Negative Breast Cancer ◽  
Anticancer Agents ◽  
Breast Cancer Cells ◽  
Triple Negative ◽  
3D Qsar ◽  
Qsar Model ◽  
Biological Evaluation ◽  
Design Synthesis ◽  
Synthesis And Biological Evaluation

New highly potent and selective 6,N2-diaryl-1,3,5-triazine-2,4-diamines were designed and prepared using the 3D-QSAR model developed earlier.

Synthesis and biological evaluation of phenolic 4,5-dihydroisoxazoles and 3-hydroxy ketones as estrogen receptor α and β agonists

2010 ◽  
Vol 18 (10) ◽  
pp. 3437-3447 ◽  
Author(s):  
Pekka K. Poutiainen ◽  
Tuomas A. Venäläinen ◽  
Mikael Peräkylä ◽  
Juha M. Matilainen ◽  
Sami Väisänen ◽  
...  
Keyword(s):  
Estrogen Receptor ◽  
Estrogen Receptor Α ◽  
Biological Evaluation ◽  
Hydroxy Ketones ◽  
Synthesis And Biological Evaluation
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