Design, synthesis, and biological evaluation of novel (1-thioxo-1,2,3,4-tetrahydro-β-carbolin-9-yl)acetic acids as selective inhibitors for AKR1B1

2012 ◽  
Vol 20 (1) ◽  
pp. 356-367 ◽  
Author(s):  
Daisuke Minehira ◽  
Daisuke Takeda ◽  
Hirokazu Urata ◽  
Atsushi Kato ◽  
Isao Adachi ◽  
...  
Keyword(s):  
Biological Evaluation ◽  
Selective Inhibitors ◽  
Design Synthesis ◽  
Synthesis And Biological Evaluation ◽  
Acetic Acids

Design, synthesis and biological evaluation of new tryptamine and tetrahydro-β-carboline-based selective inhibitors of CDK4

2008 ◽  
Vol 16 (16) ◽  
pp. 7728-7739 ◽  
Author(s):  
Paul R. Jenkins ◽  
James Wilson ◽  
Daniel Emmerson ◽  
Marcos D. Garcia ◽  
Matthew R. Smith ◽  
...  
Keyword(s):  
Biological Evaluation ◽  
Selective Inhibitors ◽  
Design Synthesis ◽  
Synthesis And Biological Evaluation

Structure‐Based Design, Synthesis, and Biological Evaluation of Hsp90β‐Selective Inhibitors

2021 ◽  
Author(s):  
Subhabrata Chaudhury ◽  
Penchala Narasimharao Meka ◽  
Monimoy Banerjee ◽  
Caitlin N. Kent ◽  
Brian S. J. Blagg
Keyword(s):  
Biological Evaluation ◽  
Selective Inhibitors ◽  
Design Synthesis ◽  
Synthesis And Biological Evaluation

scholarly journals Conformationally restricted quinazolone derivatives as PI3Kδ-selective inhibitors: the design, synthesis and biological evaluation

MedChemComm ◽  
2019 ◽  
Vol 10 (3) ◽  
pp. 413-420 ◽  
Author(s):  
Xiaodong Ma ◽  
Fang Fang ◽  
Qiangqiang Tao ◽  
Li Shen ◽  
Guochen Zhong ◽  
...  
Keyword(s):  
Biological Evaluation ◽  
Selective Inhibitors ◽  
Conformational Restriction ◽  
Design Synthesis ◽  
Conformationally Restricted ◽  
Synthesis And Biological Evaluation

A series of structurally novel quinazolone-based PI3Kδ-selective inhibitors were designed and synthesized via the approach of conformational restriction.

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