A novel delocalized lipophilic cation-chlorambucil conjugate inhibits P-glycoprotein in HepG2/ADM cells

Bioorganic & Medicinal Chemistry ◽

10.1016/j.bmc.2017.08.003 ◽

2017 ◽

Vol 25 (20) ◽

pp. 5461-5467 ◽

Author(s):

Teng Liu ◽

Yongbo Peng ◽

Xiong Li ◽

Lian Liu ◽

Fang Liu ◽

...

Keyword(s):

P Glycoprotein ◽

Lipophilic Cation

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Pharmacogenetics of Clozapine: In Vivo Role of Cytochrome P450 Isoforms and P-Glycoprotein

Pharmacopsychiatry ◽

10.1055/s-0028-1088256 ◽

2008 ◽

Vol 41 (05) ◽

Author(s):

E Jaquenoud-Sirot ◽

B Knezevic ◽

G Perla Morena ◽

P Baumann ◽

CB Eap

Keyword(s):

Cytochrome P450 ◽

P Glycoprotein ◽

Cytochrome P450 Isoforms

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Inhibition of P-glycoprotein at the blood brain barrier by phytochemicals derived from traditional Chinese medicine

Planta Medica ◽

10.1055/s-0029-1234258 ◽

2009 ◽

Vol 75 (09) ◽

Author(s):

T Efferth

Keyword(s):

Chinese Medicine ◽

Traditional Chinese Medicine ◽

Blood Brain Barrier ◽

Brain Barrier ◽

P Glycoprotein ◽

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Influence of P-glycoprotein (P-gp) induction on the pharmacokinetics of risperidone and paliperidone in mouse brain

Pharmacopsychiatry ◽

10.1055/s-0029-1240137 ◽

2009 ◽

Vol 42 (05) ◽

Author(s):

D Holthoewer ◽

C Hiemke ◽

U Schmitt

Keyword(s):

Mouse Brain ◽

Glycoprotein P ◽

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Structure activity-relationships of P-Glycoprotein modulation using a small library of macrocyclic lathyrane diterpenes

Planta Medica ◽

10.1055/s-0032-1320394 ◽

2012 ◽

Vol 78 (11) ◽

Author(s):

M Reis ◽

RJ Ferreira ◽

MMM Santos ◽

DJVA dos Santos ◽

J Molnár ◽

...

Keyword(s):

Structure Activity Relationships ◽

Structure Activity ◽

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The neuroendocrinological role of P-glycoprotein

Experimental and Clinical Endocrinology & Diabetes ◽

10.1055/s-2005-920486 ◽

2005 ◽

Vol 113 (08) ◽

Author(s):

M Ebinger ◽

MB Müller ◽

M Uhr

Keyword(s):

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Faculty Opinions recommendation of Projection structure of P-glycoprotein by electron microscopy. Evidence for a closed conformation of the nucleotide binding domains.

Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature ◽

10.3410/f.1009972.140509 ◽

2002 ◽

Author(s):

Wil Konings

Keyword(s):

Electron Microscopy ◽

Nucleotide Binding ◽

Closed Conformation ◽

Binding Domains ◽

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Faculty Opinions recommendation of Distribution of gefitinib to the brain is limited by P-glycoprotein (ABCB1) and breast cancer resistance protein (ABCG2)-mediated active efflux.

Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature ◽

10.3410/f.3171959.2859057 ◽

2010 ◽

Author(s):

Susan Bates

Keyword(s):

Breast Cancer ◽

Breast Cancer Resistance Protein ◽

Cancer Resistance ◽

Active Efflux ◽

P Glycoprotein ◽

Resistance Protein ◽

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Faculty Opinions recommendation of MicroRNA-145 post-transcriptionally regulates the expression and function of P-glycoprotein in intestinal epithelial cells.

Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature ◽

10.3410/f.718002948.793475505 ◽

2013 ◽

Author(s):

Ravinder Gill ◽

Seema Saksena

Keyword(s):

Epithelial Cells ◽

Intestinal Epithelial Cells ◽

Intestinal Epithelial ◽

P Glycoprotein ◽

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Faculty Opinions recommendation of Variability in P-glycoprotein inhibitory potency (IC₅₀) using various in vitro experimental systems: implications for universal digoxin drug-drug interaction risk assessment decision criteria.

Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature ◽

10.3410/f.718043074.793480891 ◽

2013 ◽

Author(s):

Bruno Stieger

Keyword(s):

Risk Assessment ◽

Drug Interaction ◽

Decision Criteria ◽

Inhibitory Potency ◽

Experimental Systems ◽

P Glycoprotein ◽

Drug Drug Interaction

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Faculty Opinions recommendation of Prevention of seizure-induced up-regulation of endothelial P-glycoprotein by COX-2 inhibition.

Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature ◽

10.3410/f.720394271.793506036 ◽

2015 ◽

Author(s):

Andres Miguel Kanner

Keyword(s):

P Glycoprotein ◽

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