N-(3,5-Dichloro-4-(2,4,6-trichlorophenoxy)phenyl)benzenesulfonamide: A new dual-target inhibitor of mitochondrial complex II and complex III via structural simplification

2020 ◽  
Vol 28 (5) ◽  
pp. 115299 ◽  
Author(s):  
Hua Cheng ◽  
Hong-Fu Liu ◽  
Lu Yang ◽  
Rui Zhang ◽  
Cheng Chen ◽  
...  
Keyword(s):  
Complex Iii ◽  
Mitochondrial Complex ◽  
Complex Ii ◽  
Structural Simplification ◽  
Dual Target

Discovery of 1,2,4-triazole-1,3-disulfonamides as dual inhibitors of mitochondrial complex II and complex III

2015 ◽  
Vol 39 (9) ◽  
pp. 7281-7292 ◽  
Author(s):  
Hua Cheng ◽  
Yan-Qing Shen ◽  
Xia-Yan Pan ◽  
Yi-Ping Hou ◽  
Qiong-You Wu ◽  
...  
Keyword(s):  
Complex Iii ◽  
Dual Function ◽  
Mitochondrial Complex ◽  
Complex Ii ◽  
Dual Inhibitors

1,2,4-Triazole-1,3-disulfonamide derivatives as dual function inhibitors of mitochondrial complex II (SQR) and complex III (cyt bc1) were discovered.

Mutations in TTC19 cause mitochondrial complex III deficiency and neurological impairment in humans and flies

2011 ◽  
Vol 43 (3) ◽  
pp. 259-263 ◽  
Author(s):  
Daniele Ghezzi ◽  
Paola Arzuffi ◽  
Mauro Zordan ◽  
Caterina Da Re ◽  
Costanza Lamperti ◽  
...  
Keyword(s):  
Neurological Impairment ◽  
Complex Iii ◽  
Mitochondrial Complex

scholarly journals Exome sequencing identifies NFS 1 deficiency in a novel Fe‐S cluster disease, infantile mitochondrial complex II / III deficiency

2013 ◽  
Vol 2 (1) ◽  
pp. 73-80 ◽  
Author(s):  
Sali M. K. Farhan ◽  
Jian Wang ◽  
John F. Robinson ◽  
Piya Lahiry ◽  
Victoria M. Siu ◽  
...  
Keyword(s):  
Exome Sequencing ◽  
Mitochondrial Complex ◽  
Complex Ii

scholarly journals Mitochondrial complex III Qi-site inhibitor resistance mutations found in laboratory selected mutants and field isolates

2018 ◽  
Vol 75 (8) ◽  
pp. 2107-2114 ◽  
Author(s):  
Pierre Mounkoro ◽  
Thomas Michel ◽  
Rafik Benhachemi ◽  
Georgiana Surpateanu ◽  
Bogdan I Iorga ◽  
...  
Keyword(s):  
Complex Iii ◽  
Mitochondrial Complex ◽  
Resistance Mutations ◽  
Field Isolates ◽  
Inhibitor Resistance
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