Carbonic anhydrase inhibitors: Valdecoxib binds to a different active site region of the human isoform II as compared to the structurally related cyclooxygenase II ‘selective’ inhibitor celecoxib

2006 ◽  
Vol 16 (2) ◽  
pp. 437-442 ◽  
Author(s):  
Anna Di Fiore ◽  
Carlo Pedone ◽  
Katia D’Ambrosio ◽  
Andrea Scozzafava ◽  
Giuseppina De Simone ◽  
...  
Keyword(s):  
Carbonic Anhydrase ◽  
Active Site ◽  
Selective Inhibitor ◽  
Carbonic Anhydrase Inhibitors ◽  
Active Site Region

Out of the active site binding pocket for carbonic anhydrase inhibitors

2015 ◽  
Vol 51 (2) ◽  
pp. 302-305 ◽  
Author(s):  
Katia D'Ambrosio ◽  
Simone Carradori ◽  
Simona M. Monti ◽  
Martina Buonanno ◽  
Daniela Secci ◽  
...  
Keyword(s):  
Carbonic Anhydrase ◽  
Active Site ◽  
Binding Pocket ◽  
Carbonic Anhydrase Ii ◽  
Carbonic Anhydrase Inhibitors ◽  
Human Carbonic Anhydrase ◽  
Site Binding

2-Benzylsulfinylbenzoic acid binds to human carbonic anhydrase II in a mode completely different from any other class of carbonic anhydrase inhibitors investigated so far.

scholarly journals 2-Mercaptobenzoxazoles: a class of carbonic anhydrase inhibitors with a novel binding mode to the enzyme active site

2020 ◽  
Vol 56 (59) ◽  
pp. 8297-8300
Author(s):  
Murat Bozdag ◽  
Claudiu T. Supuran ◽  
Davide Esposito ◽  
Andrea Angeli ◽  
Fabrizio Carta ◽  
...  
Keyword(s):  
Carbonic Anhydrase ◽  
Active Site ◽  
Binding Mode ◽  
Lead Compound ◽  
Carbonic Anhydrase Inhibitors ◽  
Enzyme Active Site

2-Mercaptobenzoxazole represents an interesting lead compound alternative to the classical sulfonamides for the development of selective carbonic anhydrase inhibitors.

Carbonic Anhydrase Inhibitors with Dual-Tail Moieties To Match the Hydrophobic and Hydrophilic Halves of the Carbonic Anhydrase Active Site

2015 ◽  
Vol 58 (3) ◽  
pp. 1494-1501 ◽  
Author(s):  
Rajendra P. Tanpure ◽  
Bin Ren ◽  
Thomas S. Peat ◽  
Laurent F. Bornaghi ◽  
Daniela Vullo ◽  
...  
Keyword(s):  
Carbonic Anhydrase ◽  
Active Site ◽  
Carbonic Anhydrase Inhibitors

scholarly journals Catechols: a new class of carbonic anhydrase inhibitors

2020 ◽  
Vol 56 (85) ◽  
pp. 13033-13036 ◽  
Author(s):  
Katia D'Ambrosio ◽  
Simone Carradori ◽  
Stefania Cesa ◽  
Andrea Angeli ◽  
Simona M. Monti ◽  
...  
Keyword(s):  
Carbonic Anhydrase ◽  
Water Molecule ◽  
Deep Water ◽  
Active Site ◽  
Bound Water ◽  
Binding Mode ◽  
Carbonic Anhydrase Inhibitors ◽  
New Class

Catechols adopt a peculiar binding mode to the CA active site which involves both the zinc bound water molecule and the “deep water”.

Kinetic characterization of the active site region of carbonic anhydrase

1983 ◽  
Vol 79 ◽  
pp. 151-152 ◽  
Author(s):  
E. Grell ◽  
B.S. Prabhananda ◽  
E. Rittger ◽  
H.H. Grünhagen
Keyword(s):  
Carbonic Anhydrase ◽  
Active Site ◽  
Kinetic Characterization ◽  
Active Site Region

scholarly journals Cancer Drug Development of Carbonic Anhydrase Inhibitors beyond the Active Site

Molecules ◽  
2018 ◽  
Vol 23 (5) ◽  
pp. 1045 ◽  
Author(s):  
Srishti Singh ◽  
Carrie Lomelino ◽  
Mam Mboge ◽  
Susan Frost ◽  
Robert McKenna
Keyword(s):  
Carbonic Anhydrase ◽  
Drug Development ◽  
Active Site ◽  
Cancer Drug ◽  
Carbonic Anhydrase Inhibitors
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