Design, synthesis and evaluation of novel, potent DNA alkylating agents and their antibody-drug conjugates (ADCs)

Bioorganic & Medicinal Chemistry Letters ◽

10.1016/j.bmcl.2019.07.031 ◽

2019 ◽

Vol 29 (17) ◽

pp. 2455-2458

Author(s):

Emily E. Reid ◽

Katie E. Archer ◽

Manami Shizuka ◽

Molly A. McShea ◽

Erin K. Maloney ◽

...

Keyword(s):

Alkylating Agents ◽

Design Synthesis ◽

Antibody Drug Conjugates ◽

Drug Conjugates ◽

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Abstract C160: New class of DNA-alkylating agents with a suitable tolerability profile created for use in antibody-drug conjugates (ADCs).

10.1158/1535-7163.targ-13-c160 ◽

2013 ◽

Author(s):

Michael Miller ◽

Nathan Fishkin ◽

Wei Li ◽

Emily Reid ◽

Katie Archer ◽

...

Keyword(s):

Alkylating Agents ◽

Tolerability Profile ◽

Antibody Drug Conjugates ◽

New Class ◽

Drug Conjugates ◽

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Abstract C162: Antibody-Drug Conjugates (ADCs) with novel IGN DNA-alkylating agents display potent antigen-specific activity against hematologic and solid tumor xenograft models.

10.1158/1535-7163.targ-13-c162 ◽

2013 ◽

Author(s):

Kathleen Whiteman ◽

Holly Johnson ◽

Alan Wilhelm ◽

Michael Miller ◽

Wei Li ◽

...

Keyword(s):

Solid Tumor ◽

Specific Activity ◽

Alkylating Agents ◽

Tumor Xenograft ◽

Antibody Drug Conjugates ◽

Drug Conjugates ◽

Xenograft Models ◽

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Design, Synthesis, and Biological Evaluation of Antibody−Drug Conjugates Comprised of Potent Camptothecin Analogues

Bioconjugate Chemistry ◽

10.1021/bc9001097 ◽

2009 ◽

Vol 20 (6) ◽

pp. 1242-1250 ◽

Author(s):

Patrick J. Burke ◽

Peter D. Senter ◽

David W. Meyer ◽

Jamie B. Miyamoto ◽

Martha Anderson ◽

...

Keyword(s):

Biological Evaluation ◽

Design Synthesis ◽

Antibody Drug Conjugates ◽

Drug Conjugates ◽

Synthesis And Biological Evaluation ◽

Camptothecin Analogues ◽

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Design, Synthesis, and Biochemical Evaluation of Alpha‐Amanitin Derivatives Containing Analogs of the trans ‐Hydroxyproline Residue for Potential Use in Antibody‐Drug Conjugates

Chemistry - A European Journal ◽

10.1002/chem.202102062 ◽

2021 ◽

Author(s):

Kaveh Matinkhoo ◽

Antonio A. W. L. Wong ◽

Chido M. Hambira ◽

Brandon Kato ◽

Charlie Wei ◽

...

Keyword(s):

Design Synthesis ◽

Antibody Drug Conjugates ◽

Drug Conjugates ◽

Biochemical Evaluation ◽

Alpha Amanitin ◽

Potential Use ◽

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Design, synthesis, and biochemical evaluation of alpha‐amanitin derivatives containing analogs of the trans‐hydroxyproline residue for potential use in antibody‐drug conjugates

Chemistry - A European Journal ◽

10.1002/chem.202101373 ◽

2021 ◽

Author(s):

Kaveh Matinkhoo ◽

Antonio AWL Wong ◽

Chido M. Hambira ◽

Brandon Kato ◽

Charlie Wei ◽

...

Keyword(s):

Design Synthesis ◽

Antibody Drug Conjugates ◽

Drug Conjugates ◽

Biochemical Evaluation ◽

Alpha Amanitin ◽

Potential Use ◽

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Design, Synthesis, and Biological Evaluation of Tubulysin Analogues, Linker-Drugs, and Antibody–Drug Conjugates, Insights into Structure–Activity Relationships, and Tubulysin–Tubulin Binding Derived from X-ray Crystallographic Analysis

The Journal of Organic Chemistry ◽

10.1021/acs.joc.0c02755 ◽

2021 ◽

Vol 86 (4) ◽

pp. 3377-3421

Author(s):

K. C. Nicolaou ◽

Saiyong Pan ◽

Kiran K. Pulukuri ◽

Qiuji Ye ◽

Stephan Rigol ◽

...

Keyword(s):

Biological Evaluation ◽

Crystallographic Analysis ◽

Design Synthesis ◽

X Ray ◽

Antibody Drug Conjugates ◽

Drug Conjugates ◽

Structure Activity ◽

Tubulin Binding ◽

Synthesis And Biological Evaluation ◽

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Abstract 822: Thienoindoles, a novel class of DNA minor groove alkylating agents highly suited for the generation of novel antibody drug conjugates (ADCs)

10.1158/1538-7445.am2014-822 ◽

2014 ◽

Author(s):

Barbara Valsasina ◽

Fabio Gasparri ◽

Italo Beria ◽

Nicoletta Colombo ◽

Paolo Orsini ◽

...

Keyword(s):

Alkylating Agents ◽

Minor Groove ◽

Antibody Drug Conjugates ◽

Dna Minor Groove ◽

Drug Conjugates ◽

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Design, Synthesis, and Structure–Activity Relationships of Novel Tetrahydroisoquinolino Benzodiazepine Dimer Antitumor Agents and Their Application in Antibody–Drug Conjugates

Journal of Medicinal Chemistry ◽

10.1021/acs.jmedchem.0c01385 ◽

2020 ◽

Vol 63 (22) ◽

pp. 13913-13950

Author(s):

Naidu S. Chowdari ◽

Yong Zhang ◽

Ivar McDonald ◽

Walter Johnson ◽

David R. Langley ◽

...

Keyword(s):

Antitumor Agents ◽

Design Synthesis ◽

Antibody Drug Conjugates ◽

Structure Activity Relationships ◽

Drug Conjugates ◽

Structure Activity ◽

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Design, synthesis and biological evaluation of phenol-linked uncialamycin antibody-drug conjugates

Bioorganic & Medicinal Chemistry Letters ◽

10.1016/j.bmcl.2019.126782 ◽

2020 ◽

Vol 30 (1) ◽

pp. 126782 ◽

Author(s):

Yam B. Poudel ◽

Chetana Rao ◽

Srikanth Kotapati ◽

Madhura Deshpande ◽

Lourdes Thevanayagam ◽

...

Keyword(s):

Biological Evaluation ◽

Design Synthesis ◽

Antibody Drug Conjugates ◽

Drug Conjugates ◽

Synthesis And Biological Evaluation ◽

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Abstract 652: Antibody-drug conjugates (ADCs) of indolino-benzodiazepine DNA-alkylating agents

10.1158/1538-7445.am2015-652 ◽

2015 ◽

Author(s):

Michael L. Miller ◽

Manami Shizuka ◽

Nathan Fishkin ◽

Emily Reid ◽

Katie Archer ◽

...

Keyword(s):

Alkylating Agents ◽

Antibody Drug Conjugates ◽

Drug Conjugates ◽

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