Design, Synthesis, and Biological Evaluation of Antibody−Drug Conjugates Comprised of Potent Camptothecin Analogues

Drug Conjugates ◽

Camptothecin Analogues ◽

Design, Synthesis, and Biological Evaluation of Tubulysin Analogues, Linker-Drugs, and Antibody–Drug Conjugates, Insights into Structure–Activity Relationships, and Tubulysin–Tubulin Binding Derived from X-ray Crystallographic Analysis

The Journal of Organic Chemistry ◽

10.1021/acs.joc.0c02755 ◽

2021 ◽

Vol 86 (4) ◽

pp. 3377-3421

Author(s):

K. C. Nicolaou ◽

Saiyong Pan ◽

Kiran K. Pulukuri ◽

Qiuji Ye ◽

Stephan Rigol ◽

...

Keyword(s):

Biological Evaluation ◽

Crystallographic Analysis ◽

Design Synthesis ◽

X Ray ◽

Drug Conjugates ◽

Structure Activity ◽

Tubulin Binding ◽

Design, synthesis and biological evaluation of phenol-linked uncialamycin antibody-drug conjugates

Bioorganic & Medicinal Chemistry Letters ◽

10.1016/j.bmcl.2019.126782 ◽

2020 ◽

Vol 30 (1) ◽

pp. 126782 ◽

Cited By ~ 3

Author(s):

Yam B. Poudel ◽

Chetana Rao ◽

Srikanth Kotapati ◽

Madhura Deshpande ◽

Lourdes Thevanayagam ◽

...

Keyword(s):

Biological Evaluation ◽

Design Synthesis ◽

Drug Conjugates ◽

Improved Total Synthesis of Tubulysins and Design, Synthesis, and Biological Evaluation of New Tubulysins with Highly Potent Cytotoxicities against Cancer Cells as Potential Payloads for Antibody–Drug Conjugates

Journal of the American Chemical Society ◽

10.1021/jacs.7b12692 ◽

2018 ◽

Vol 140 (10) ◽

pp. 3690-3711 ◽

Cited By ~ 25

Author(s):

K. C. Nicolaou ◽

Rohan D. Erande ◽

Jun Yin ◽

Dionisios Vourloumis ◽

Monette Aujay ◽

...

Keyword(s):

Total Synthesis ◽

Cancer Cells ◽

Biological Evaluation ◽

Design Synthesis ◽

Drug Conjugates ◽

Synthesis and Biological Evaluation of Shishijimicin A-Type Linker-Drugs and Antibody–Drug Conjugates

Journal of the American Chemical Society ◽

10.1021/jacs.0c06554 ◽

2020 ◽

Vol 142 (29) ◽

pp. 12890-12899

Author(s):

K. C. Nicolaou ◽

Ruofan Li ◽

Qifeng Chen ◽

Zhaoyong Lu ◽

Emmanuel N. Pitsinos ◽

...

Keyword(s):

Biological Evaluation ◽

Drug Conjugates ◽

Synthesis and Biological Evaluation of Antibody Drug Conjugates Based on an Antibody Expression System: Conamax

ACS Omega ◽

10.1021/acsomega.9b03628 ◽

2020 ◽

Vol 5 (13) ◽

pp. 7193-7200 ◽

Cited By ~ 5

Author(s):

Zhala Tawfiq ◽

Nicky C. Caiazza ◽

Spiros Kambourakis ◽

Yutaka Matsuda ◽

Benjamin Griffin ◽

...

Keyword(s):

Expression System ◽

Biological Evaluation ◽

Antibody Expression ◽

Drug Conjugates ◽

Design, synthesis and evaluation of novel, potent DNA alkylating agents and their antibody-drug conjugates (ADCs)

Bioorganic & Medicinal Chemistry Letters ◽

10.1016/j.bmcl.2019.07.031 ◽

2019 ◽

Vol 29 (17) ◽

pp. 2455-2458

Author(s):

Emily E. Reid ◽

Katie E. Archer ◽

Manami Shizuka ◽

Molly A. McShea ◽

Erin K. Maloney ◽

...

Keyword(s):

Alkylating Agents ◽

Design Synthesis ◽

Drug Conjugates ◽

Design, Synthesis, and Biochemical Evaluation of Alpha‐Amanitin Derivatives Containing Analogs of the trans ‐Hydroxyproline Residue for Potential Use in Antibody‐Drug Conjugates

Chemistry - A European Journal ◽

10.1002/chem.202102062 ◽

2021 ◽

Author(s):

Kaveh Matinkhoo ◽

Antonio A. W. L. Wong ◽

Chido M. Hambira ◽

Brandon Kato ◽

Charlie Wei ◽

...

Keyword(s):

Design Synthesis ◽

Drug Conjugates ◽

Biochemical Evaluation ◽

Alpha Amanitin ◽

Potential Use ◽

Design, synthesis, and biochemical evaluation of alpha‐amanitin derivatives containing analogs of the trans‐hydroxyproline residue for potential use in antibody‐drug conjugates

Chemistry - A European Journal ◽

10.1002/chem.202101373 ◽

2021 ◽

Author(s):

Kaveh Matinkhoo ◽

Antonio AWL Wong ◽

Chido M. Hambira ◽

Brandon Kato ◽

Charlie Wei ◽

...

Keyword(s):

Design Synthesis ◽

Drug Conjugates ◽

Biochemical Evaluation ◽

Alpha Amanitin ◽

Potential Use ◽

Design, Synthesis, and Structure–Activity Relationships of Novel Tetrahydroisoquinolino Benzodiazepine Dimer Antitumor Agents and Their Application in Antibody–Drug Conjugates

Journal of Medicinal Chemistry ◽

10.1021/acs.jmedchem.0c01385 ◽

2020 ◽

Vol 63 (22) ◽

pp. 13913-13950

Author(s):

Naidu S. Chowdari ◽

Yong Zhang ◽

Ivar McDonald ◽

Walter Johnson ◽

David R. Langley ◽

...

Keyword(s):

Antitumor Agents ◽

Design Synthesis ◽

Structure Activity Relationships ◽

Drug Conjugates ◽

Structure Activity ◽

Design, synthesis and evaluation of anti-CD123 antibody drug conjugates

Bioorganic & Medicinal Chemistry ◽

10.1016/j.bmc.2016.09.043 ◽

2016 ◽

Vol 24 (22) ◽

pp. 5855-5860 ◽

Cited By ~ 5

Author(s):

Bin Li ◽

Weiyu Zhao ◽

Xinfu Zhang ◽

Junfeng Wang ◽

Xiao Luo ◽

...

Keyword(s):

Design Synthesis ◽

Drug Conjugates ◽