Design, Synthesis, and Biological Evaluation of Tubulysin Analogues, Linker-Drugs, and Antibody–Drug Conjugates, Insights into Structure–Activity Relationships, and Tubulysin–Tubulin Binding Derived from X-ray Crystallographic Analysis

2021 ◽  
Vol 86 (4) ◽  
pp. 3377-3421
Author(s):  
K. C. Nicolaou ◽  
Saiyong Pan ◽  
Kiran K. Pulukuri ◽  
Qiuji Ye ◽  
Stephan Rigol ◽  
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Keyword(s):  
Biological Evaluation ◽  
Crystallographic Analysis ◽  
Design Synthesis ◽  
X Ray ◽  
Antibody Drug Conjugates ◽  
Drug Conjugates ◽  
Structure Activity ◽  
Tubulin Binding ◽  
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Design, Synthesis, and Biological Evaluation of Antibody−Drug Conjugates Comprised of Potent Camptothecin Analogues

2009 ◽  
Vol 20 (6) ◽  
pp. 1242-1250 ◽  
Author(s):  
Patrick J. Burke ◽  
Peter D. Senter ◽  
David W. Meyer ◽  
Jamie B. Miyamoto ◽  
Martha Anderson ◽  
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Keyword(s):  
Biological Evaluation ◽  
Design Synthesis ◽  
Antibody Drug Conjugates ◽  
Drug Conjugates ◽  
Synthesis And Biological Evaluation ◽  
Camptothecin Analogues ◽  
Antibody Drug

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2020 ◽  
Vol 30 (1) ◽  
pp. 126782 ◽  
Author(s):  
Yam B. Poudel ◽  
Chetana Rao ◽  
Srikanth Kotapati ◽  
Madhura Deshpande ◽  
Lourdes Thevanayagam ◽  
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Keyword(s):  
Biological Evaluation ◽  
Design Synthesis ◽  
Antibody Drug Conjugates ◽  
Drug Conjugates ◽  
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Vol 142 (29) ◽  
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Qifeng Chen ◽  
Zhaoyong Lu ◽  
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Biological Evaluation ◽  
Antibody Drug Conjugates ◽  
Drug Conjugates ◽  
Synthesis And Biological Evaluation ◽  
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scholarly journals Synthesis and Biological Evaluation of Antibody Drug Conjugates Based on an Antibody Expression System: Conamax

ACS Omega ◽  
2020 ◽  
Vol 5 (13) ◽  
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Author(s):  
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Nicky C. Caiazza ◽  
Spiros Kambourakis ◽  
Yutaka Matsuda ◽  
Benjamin Griffin ◽  
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Keyword(s):  
Expression System ◽  
Biological Evaluation ◽  
Antibody Drug Conjugates ◽  
Antibody Expression ◽  
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Design, synthesis and evaluation of novel, potent DNA alkylating agents and their antibody-drug conjugates (ADCs)

2019 ◽  
Vol 29 (17) ◽  
pp. 2455-2458
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Katie E. Archer ◽  
Manami Shizuka ◽  
Molly A. McShea ◽  
Erin K. Maloney ◽  
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Alkylating Agents ◽  
Design Synthesis ◽  
Antibody Drug Conjugates ◽  
Drug Conjugates ◽  
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