Cadiolide Analogues and their Precursors as New Inhibitors of Bacterial Quorum Sensing and Biofilm Formation

2021 ◽  
pp. 128498
Author(s):  
Thais A. Moreira ◽  
Isabel V. Antolínez ◽  
Wagner O. Valença ◽  
Sweta Roy ◽  
Luiz C.A. Barbosa ◽  
...  
Keyword(s):  
Quorum Sensing ◽  
Biofilm Formation ◽  
Bacterial Quorum Sensing ◽  
Bacterial Quorum

scholarly journals IgY Targeting Bacterial Quorum-Sensing Molecules in Implant-Associated Infections

Molecules ◽  
2020 ◽  
Vol 25 (17) ◽  
pp. 4027
Author(s):  
Ulrike Dapunt ◽  
Birgit Prior ◽  
Christopher Oelkrug ◽  
Jan Philippe Kretzer
Keyword(s):  
Quorum Sensing ◽  
Staphylococcus Epidermidis ◽  
Biofilm Formation ◽  
Major Complication ◽  
Underlying Mechanism ◽  
Bacterial Communication ◽  
Bacterial Quorum Sensing ◽  
Polysaccharide Intercellular Adhesion ◽  
Bacterial Quorum ◽  
Treatment Alternatives

Background: Implant-associated infections are still a major complication in the field of orthopedics. Bacteria can form biofilms on implant surfaces, making them more difficult to detect and treat. Since standard antibiotic therapy is often impaired in biofilm infections, particular interest is directed towards finding treatment alternatives. Biofilm-formation is a well-organized process during which bacteria communicate via quorum-sensing molecules (QSM). The aim of this study was to inhibit bacterial communication by directing avian IgY against specific QSM. Methods: Chicken were immunized against the following QSM: (1) AtlE, a member of the autolysin family which mediates attachment to a surface in Staphylococcus epidermidis; (2) GroEL, the bacterial heat shock protein; (3) PIA (polysaccharide intercellular adhesion), which is essential for cell–cell adhesion in biofilms. Staphylococcus epidermidis biofilms were grown and inhibition of biofilm-formation by IgYs was evaluated. Additionally, human osteoblasts were cultivated and biocompatibility of IgYs was tested. Results: We were able to demonstrate that all IgYs reduced biofilm-formation, also without prior immunization. Therefore, the response was probably not specific with regard to the QSM. Osteoblasts were activated by all IgYs which was demonstrated by microscopy and an increased release of IL-8. Conclusions: In conclusion, avian IgY inhibits biofilm-formation, though the underlying mechanism is not yet clear. However, adverse effects on local tissue cells (osteoblasts) were also observed.

scholarly journals Highly branched poly(N-isopropyl acrylamide) functionalized with an inducer molecule suppresses quorum sensing in Chromobacterium violaceum

2019 ◽  
Vol 55 (66) ◽  
pp. 9765-9768 ◽  
Author(s):  
Joanna Shepherd ◽  
Thomas Swift ◽  
Chien-Yi Chang ◽  
James R. Boyne ◽  
Stephen Rimmer ◽  
...  
Keyword(s):  
Quorum Sensing ◽  
Mode Of Action ◽  
Biofilm Formation ◽  
Chromobacterium Violaceum ◽  
Isopropyl Acrylamide ◽  
Bacterial Quorum Sensing ◽  
Bacterial Quorum

Bacterial quorum sensing has been implicated in a number of pathogenic bacterial processes, such as biofilm formation, making it a crucial target for developing materials with a novel antibiotic mode of action.

Small Molecule Inhibitors of Bacterial Quorum Sensing and Biofilm Formation

2005 ◽  
Vol 127 (37) ◽  
pp. 12762-12763 ◽  
Author(s):  
Grant D. Geske ◽  
Rachel J. Wezeman ◽  
Adam P. Siegel ◽  
Helen E. Blackwell
Keyword(s):  
Quorum Sensing ◽  
Small Molecule ◽  
Biofilm Formation ◽  
Small Molecule Inhibitors ◽  
Bacterial Quorum Sensing ◽  
Bacterial Quorum

Synthesis and biological evaluation of novel acyclic and cyclic glyoxamide based derivatives as bacterial quorum sensing and biofilm inhibitors

2017 ◽  
Vol 15 (27) ◽  
pp. 5743-5755 ◽  
Author(s):  
Shashidhar Nizalapur ◽  
Onder Kimyon ◽  
Eugene Yee ◽  
Mohan M. Bhadbhade ◽  
Mike Manefield ◽  
...  
Keyword(s):  
Quorum Sensing ◽  
Biofilm Formation ◽  
Biological Evaluation ◽  
Gram Negative Bacteria ◽  
Gram Negative ◽  
E Coli ◽  
Sensing Mechanism ◽  
Bacterial Quorum Sensing ◽  
Bacterial Quorum ◽  
Synthesis And Biological Evaluation

Novel acyclic and cyclic glyoxamides that inhibited quorum sensing mechanism and biofilm formation in Gram-negative bacteria such as P. aeruginosa and E. coli.

Inhibition of Bacterial Quorum Sensing and Biofilm Formation by Extracts of Neotropical Rainforest Plants

Planta Medica ◽  
2014 ◽  
Vol 80 (04) ◽  
pp. 343-350 ◽  
Author(s):  
Chieu Ta ◽  
Marie Freundorfer ◽  
Thien-Fah Mah ◽  
Marco Otárola-Rojas ◽  
Mario Garcia ◽  
...  
Keyword(s):  
Quorum Sensing ◽  
Biofilm Formation ◽  
Bacterial Quorum Sensing ◽  
Bacterial Quorum ◽  
Neotropical Rainforest

scholarly journals Bacterial quorum sensing and biofilm formation

2017 ◽  
Vol 8 (1) ◽  
pp. 1
Author(s):  
Ahmed Abu Saleh
Keyword(s):  
Quorum Sensing ◽  
Biofilm Formation ◽  
Bacterial Quorum Sensing ◽  
Bacterial Quorum

No Abstract available Bangladesh J Med Microbiol 2014; 08 (01): 01

scholarly journals Use of Poly (ε-Lysine) Dendrons: A Strategy Targeting Bacterial Quorum Sensing and Biofilm Formation

2014 ◽  
Vol 2014 ◽  
pp. 1-8
Author(s):  
Rahaf Issa ◽  
Steve T. Meikle ◽  
Stuart L. James ◽  
Ian R. Cooper
Keyword(s):  
Quorum Sensing ◽  
Biofilm Formation ◽  
Implantable Medical Devices ◽  
Quorum Sensing Inhibitors ◽  
Toxic Metabolites ◽  
Hyperbranched Poly ◽  
Bacterial Quorum Sensing ◽  
Bacterial Quorum ◽  
Bacterial Replication ◽  
Virulence Factor Production

Pseudomonas aeruginosa is recognised as a major aetiological agent of nosocomial infections, which are associated with multiple-antibiotic resistance. Among many of its important virulence factors is its ability to form biofilms on the surfaces of implantable medical devices and to produce toxic metabolites, pyocyanin, via an intercellular cell density-dependent signalling system of communication. In this study, poly (ε-lysine) dendrons composed of increasingly branching generations were synthesised, characterised, and examined for their effects on virulence factor production in P. aeruginosa. The results show that these hyperbranched poly (ε-lysine) dendrons, in particular the 3rd generation, can increase the efficacy of a conventional antibiotic, ciprofloxacin, and reduce pyocyanin production, with marginal effects on the rate of bacterial replication, suggesting that the observed effects are not due to dendron toxicity. Furthermore, dendron and ciprofloxacin coadministration was identified as the most effective strategy which highlights the potential of peptide-based dendrons as quorum sensing inhibitors.

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