Association between plasma homocysteine and bone density and quality parameters in the elderly

Introduction. Cardiovascular (CV) diseases and bone fractures due to osteoporosis are the leading causes of death in the elderly. Objective. The aim of this study was to demonstrate a correlation between the overall risk for CV events, and low bone density in postmenopausal women, and its impact on the incidence of serious CV events. Methods. Our prospective study involved 300 postmenopausal women. All the examinees were divided into three groups based on their measured bone density: Group I - 84 examinees with osteoporosis; Group II - 115 examinees with osteopenia; and Group III - 101 examinees with normal bone density. In all examinees the overall ten-year risk for a fatal CV event was calculated using the SCORE system tables. Results. After a 36-month follow-up, CV events occurred in 19 (6.3%) examinees. Significant differences in the incidence of CV events were demonstrated between the patients with osteoporosis, osteopenia, and normal bone density (?2=28.7; p<0.001), as well as between those with a high and low CV risk (?2=22.6; p<0.001). Multivariate logistic regression analysis showed that smoking (OR: 2.23; 95% CI: 1.02 to 6.19; p=0.035), and increase of overall CV score (OR: 1.36; 95% CI: 1.17 to 1.58; p<0.001) are associated with increased CV event risk, while the increase of T score value is associated with decreased risk of CV event (OR: 0.42; 95% CI: 0.25 to 0.73; p=0.002). Conclusion. Measurement of bone density with a standard assessment of the total CV risk could be useful for selecting women who need intensive prevention and treatment of atherosclerosis.

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Can study of bone density in adolescents with anorexia nervosa provide clues to prevention of osteoporosis in the elderly?

Journal of Adolescent Health ◽

10.1016/1054-139x(93)90170-t ◽

1993 ◽

Vol 14 (4) ◽

pp. 256

Author(s):

I LITT

Keyword(s):

Anorexia Nervosa ◽

Bone Density ◽

The Elderly ◽

Prevention Of Osteoporosis

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Relationship among Plasma Homocysteine, Folate, Vitamin B12and Nutrient Intake and Neurocognitive Function in the Elderly

The Korean Journal of Nutrition ◽

10.4163/kjn.2011.44.6.498 ◽

2011 ◽

Vol 44 (6) ◽

pp. 498 ◽

Cited By ~ 9

Author(s):

Hee Jung Kim ◽

Hyesook Kim ◽

Ki Nam Kim ◽

Ggotpin Kim ◽

Jung In Son ◽

...

Keyword(s):

Nutrient Intake ◽

The Elderly ◽

Neurocognitive Function ◽

Plasma Homocysteine

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Recapitulation of the Genetic Association of PLXNA2 with Bone Density and Osteoporosis via In Vitro Experiments Using a Korean Female Cohort

Journal of Medical Imaging and Health Informatics ◽

10.1166/jmihi.2020.3064 ◽

2020 ◽

Vol 10 (6) ◽

pp. 1418-1422

Author(s):

Sangwook Park ◽

Ji-Eun Oh ◽

Hyun-Seok Jin

Keyword(s):

Bone Density ◽

Genetic Association ◽

Elderly Women ◽

Osteoporosis Treatment ◽

The Elderly ◽

Bone Morphogenetic Protein 2 ◽

Nucleotide Polymorphisms ◽

Mineral Density ◽

Female Cohort

Osteoporosis is a bone disorder in which the imbalance of osteoclasts and osteoblasts leads to bone-destructive diseases especially among elderly women. Several factors, including genetic and environmental factors, contribute to the pathogenesis of these diseases. Bone mineral density (BMD) is a robust factor that influences osteoporosis; the development of osteoporosis in the elderly is estimated based on the BMD. Our previous microarray assay using murine preosteoblast cells revealed that Plexin A2 is associated with the differentiation and mineralization of bone-forming osteoblasts via bone morphogenetic protein 2 signaling. For our in vitro replication study using a Korean female cohort, we analyzed the genetic variation of PLEXIN A2 (PLXNA2) and its paralog genes (PLXNA1, A3, and A4) based on 125 single nucleotide polymorphisms (SNPs) associated with bone density and osteoporosis. In this study, the PLXNA2 gene was confirmed as a robust candidate gene associated with osteoporosis in Korean women. We have demonstrated that the SNPs rs4844649 (p = 9.3×10−3) and rs3748737 (p = 2.7×10−3) of PLXNA2 were the most significantly associated with bone density and osteoporosis, respectively. Consequently, this study demonstrates that the PLXNA2 gene is implicated in bone metabolism, further supporting the genetic association between polymorphisms in PLXNA2 and osteoporosis. Our current findings also suggest that polymorphisms in PLXNA2 may serve as feasible clinical targets for osteoporosis treatment in the future.

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Lateral lumbar interbody fusion in the elderly: a 10-year experience

Journal of Neurosurgery Spine ◽

10.3171/2018.3.spine171147 ◽

2018 ◽

Vol 29 (5) ◽

pp. 525-529 ◽

Cited By ~ 5

Author(s):

Nitin Agarwal ◽

Andrew Faramand ◽

Nima Alan ◽

Zachary J. Tempel ◽

D. Kojo Hamilton ◽

...

Keyword(s):

Bone Density ◽

Femoral Neck ◽

Blood Loss ◽

Elderly Population ◽

Interbody Fusion ◽

Length Of Hospital Stay ◽

The Elderly ◽

Lumbar Interbody Fusion ◽

The Mean ◽

Graft Subsidence

OBJECTIVEElderly patients, often presenting with multiple medical comorbidities, are touted to be at an increased risk of peri- and postoperative complications following spine surgery. Various minimally invasive surgical techniques have been developed and employed to treat an array of spinal conditions while minimizing complications. Lateral lumbar interbody fusion (LLIF) is one such approach. The authors describe clinical outcomes in patients over the age of 70 years following stand-alone LLIF.METHODSA retrospective query of a prospectively maintained database was performed for patients over the age of 70 years who underwent stand-alone LLIF. Patients with posterior segmental fixation and/or fusion were excluded. The preoperative and postoperative values for the Oswestry Disability Index (ODI) were analyzed to compare outcomes after intervention. Femoral neck t-scores were acquired from bone density scans and correlated with the incidence of graft subsidence.RESULTSAmong the study cohort of 55 patients, the median age at the time of surgery was 74 years (range 70–87 years). Seventeen patients had at least 3 medical comorbidities at surgery. Twenty-three patients underwent a 1-level, 14 a 2-level, and 18 patients a 3-level or greater stand-alone lateral fusion. The median estimated blood loss was 25 ml (range 5–280 ml). No statistically significant relationship was detected between volume of blood loss and the number of operative levels. The median length of hospital stay was 2 days (range 1–4 days). No statistically significant relationship was observed between the length of hospital stay and age at the time of surgery. There was one intraoperative death secondary to cardiac arrest, with a mortality rate of 1.8%. One patient developed a transient femoral nerve injury. Five patients with symptomatic graft subsidence subsequently underwent posterior instrumentation. A lower femoral neck t-score < −1.0 correlated with a higher incidence of graft subsidence (p = 0.006). The mean ODI score 1 year postoperatively of 31.1 was significantly (p = 0.003) less than the mean preoperative ODI score of 46.2.CONCLUSIONSStand-alone LLIF can be safely and effectively performed in the elderly population. Careful evaluation of preoperative bone density parameters should be employed to minimize risk of subsidence and need for additional surgery. Despite an association with increased comorbidities, age alone should not be a deterrent when considering stand-alone LLIF in the elderly population.

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