Computational Analysis of the Neurokinin-1 Receptor Interactions with Antagonists

Biophysical Journal ◽

10.1016/j.bpj.2020.11.956 ◽

2021 ◽

Vol 120 (3) ◽

pp. 123a

Author(s):

Marcelo Cardoso dos ◽

Reis Melo ◽

Cesar de ◽

la Fuente-Nunez

Keyword(s):

Computational Analysis ◽

Neurokinin 1 Receptor ◽

Receptor Interactions ◽

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Role of kappa-opioids and neurokinin 1 receptor interactions on visceral nociception in a rat model

Gastroenterology ◽

10.1016/s0016-5085(03)83100-1 ◽

2003 ◽

Vol 124 (4) ◽

pp. A612

Author(s):

Tobias Liebregts ◽

Birgit Adam ◽

Anton Bertel ◽

Venus Eishabady ◽

Guido Gerken ◽

...

Keyword(s):

Rat Model ◽

Neurokinin 1 Receptor ◽

Kappa Opioids ◽

Visceral Nociception ◽

Receptor Interactions ◽

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A Neurokinin-1 Receptor Antagonist for the Treatment of Pruritus in Patients With Epidermolysis Bullosa

Case Medical Research ◽

10.31525/ct1-nct03836001 ◽

2000 ◽

Author(s):

Keyword(s):

Receptor Antagonist ◽

Epidermolysis Bullosa ◽

Neurokinin 1 Receptor ◽

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Faculty Opinions recommendation of Efficacy and safety of a neurokinin-1 receptor antagonist in postmenopausal women with overactive bladder with urge urinary incontinence.

Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature ◽

10.3410/f.1053869.505810 ◽

2006 ◽

Author(s):

Rodolfo Testa

Keyword(s):

Urinary Incontinence ◽

Overactive Bladder ◽

Receptor Antagonist ◽

Postmenopausal Women ◽

Urge Urinary Incontinence ◽

Efficacy And Safety ◽

Neurokinin 1 Receptor ◽

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Faculty Opinions recommendation of Neurokinin 1 receptor antagonism as a possible therapy for alcoholism.

Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature ◽

10.3410/f.1103574.559648 ◽

2008 ◽

Author(s):

Steven D Douglas

Keyword(s):

Receptor Antagonism ◽

Neurokinin 1 Receptor ◽

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Neurokinin-1 Receptor Antagonists in Lung Cancer Therapy

Letters in Drug Design & Discovery ◽

10.2174/1570180814666170327163854 ◽

2017 ◽

Vol 14 (12) ◽

Author(s):

Miguel Munoz ◽

Marisa Rosso ◽

Rafael Covenas

Keyword(s):

Lung Cancer ◽

Cancer Therapy ◽

Receptor Antagonists ◽

Neurokinin 1 Receptor ◽

Lung Cancer Therapy ◽

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NERVE INJURY-INDUCED MECHANICAL BUT NOT THERMAL HYPERALGESIA IS ATTENUATED IN NEUROKININ-1 RECEPTOR KNOCKOUT MICE

Journal of the Peripheral Nervous System ◽

10.1046/j.1529-8027.2000.00022-24.x ◽

2000 ◽

Vol 5 (4) ◽

pp. 242-242

Author(s):

H Mansikka ◽

Rn Sheth ◽

C DeVries ◽

H Lee ◽

R Winchurch ◽

...

Keyword(s):

Nerve Injury ◽

Knockout Mice ◽

Thermal Hyperalgesia ◽

Neurokinin 1 Receptor ◽

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A lipid-anchored neurokinin 1 receptor antagonist prolongs pain relief by a three-pronged mechanism of action targeting the receptor at the plasma membrane and in endosomes

Journal of Biological Chemistry ◽

10.1016/j.jbc.2021.100345 ◽

2021 ◽

Vol 296 ◽

pp. 100345

Author(s):

Quynh N. Mai ◽

Priyank Shenoy ◽

Tim Quach ◽

Jeffri S. Retamal ◽

Arisbel B. Gondin ◽

...

Keyword(s):

Plasma Membrane ◽

Pain Relief ◽

Receptor Antagonist ◽

Mechanism Of Action ◽

Neurokinin 1 Receptor ◽

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Interaction of glutamine 165 in the fourth transmembrane segment of the human neurokinin-1 receptor with quinuclidine antagonists.

Journal of Biological Chemistry ◽

10.1016/s0021-9258(17)36559-6 ◽

1994 ◽

Vol 269 (21) ◽

pp. 14957-14961

Author(s):

T.M. Fong ◽

H. Yu ◽

M.A. Cascieri ◽

D. Underwood ◽

C.J. Swain ◽

...

Keyword(s):

Transmembrane Segment ◽

Neurokinin 1 Receptor ◽

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Specific residues at the top of transmembrane segment V and VI of the neurokinin-1 receptor involved in binding of the nonpeptide antagonist CP 96,345 [corrected]

Journal of Biological Chemistry ◽

10.1016/s0021-9258(19)51031-6 ◽

1994 ◽

Vol 269 (39) ◽

pp. 23959-23964

Author(s):

U. Gether ◽

L. Nilsson ◽

J.A. Lowe ◽

T.W. Schwartz

Keyword(s):

Transmembrane Segment ◽

Neurokinin 1 Receptor ◽

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Fosaprepitant (MK-0517): a neurokinin-1 receptor antagonist for the prevention of chemotherapy-induced nausea and vomiting

Expert Opinion on Investigational Drugs ◽

10.1517/13543784.16.12.1977 ◽

2007 ◽

Vol 16 (12) ◽

pp. 1977-1985 ◽

Author(s):

Rudolph M Navari

Keyword(s):

Receptor Antagonist ◽

Nausea And Vomiting ◽

Neurokinin 1 Receptor ◽

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