Neural Correlates of Affective Disturbances: A Comparative Meta-analysis of Negative Affect Processing in Borderline Personality Disorder, Major Depressive Disorder, and Posttraumatic Stress Disorder

2019 ◽  
Vol 4 (3) ◽  
pp. 220-232 ◽  
Author(s):  
Lars Schulze ◽  
Andreas Schulze ◽  
Babette Renneberg ◽  
Christian Schmahl ◽  
Inga Niedtfeld
Keyword(s):  
Posttraumatic Stress Disorder ◽  
Major Depressive Disorder ◽  
Personality Disorder ◽  
Stress Disorder ◽  
Meta Analysis ◽  
Neural Correlates ◽  
Borderline Personality ◽  
Major Depressive ◽  
Affective Disturbances ◽  
Affect Processing

Hippocampal volume in borderline personality disorder with and without comorbid posttraumatic stress disorder: A meta-analysis

2011 ◽  
Vol 26 (7) ◽  
pp. 452-456 ◽  
Author(s):  
E. Rodrigues ◽  
A. Wenzel ◽  
M.P. Ribeiro ◽  
L.C. Quarantini ◽  
A. Miranda-Scippa ◽  
...  
Keyword(s):  
Posttraumatic Stress Disorder ◽  
Borderline Personality Disorder ◽  
Personality Disorder ◽  
Posttraumatic Stress ◽  
Stress Disorder ◽  
Meta Analysis ◽  
Hippocampal Volume ◽  
Borderline Personality ◽  
Healthy Controls ◽  
Left And Right

AbstractBackgroundSeveral studies have found a reduction in hippocampal volume in borderline personality disorder (BPD) patients.MethodsIn order to investigate the degree to which comorbid posttraumatic stress disorder (PTSD) could account for reduction in hippocampal volume in these patients, we conducted a systematic review and meta-analysis of studies that compared hippocampal volume in BPD patients with and without PTSD relative to healthy controls.ResultsSeven articles, involving 124 patients and 147 controls, were included. We found a statistically significant reduction for the left and right hippocampus. Data from the four studies that discriminated BPD patients with and without PTSD indicate that hippocampal volumes were reduced bilaterally in BPD patients with PTSD, relative to healthy controls, but that results were mixed for BPD patients without PTSD, relative to healthy controls.ConclusionsResults from this meta-analysis suggest that hippocampal volumes are reduced in patients with BPD, relative to healthy controls, but particularly in cases in which patients are diagnosed with comorbid PTSD.

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