Effects of valproic acid and levetiracetam monotherapy on carotid intima-media and epicardial adipose tissue thickness in non-obese children with epilepsy

2020 ◽  
Vol 42 (2) ◽  
pp. 165-170
Author(s):  
Elif Karatoprak ◽  
Oyku Tosun

2020 ◽  
Vol 30 (10) ◽  
pp. 1429-1432
Author(s):  
Hatice Güneş ◽  
Hakan Güneş ◽  
Şebnem Özmen ◽  
Enes Çelik ◽  
Fatih Temiz

AbstractIntroduction:Obesity is usually related to insulin resistance and glucose metabolism disorders. The relationship between insulin resistance and epicardial adipose tissue and atrial electromechanical delay has been described in previous studies.Aim:This study aims to demonstrate the effects of metformin on epicardial adipose tissue and electromechanical delay in patients using metformin for insulin resistance.Materials and methods:A total of 30 patients using metformin for insulin resistance were included in the study. Pre-treatment and post-treatment epicardial adipose tissue and electromechanical delay were evaluated.Results:There was a statistically significant decrease in epicardial adipose tissue thickness after 3 months of metformin therapy (6.4 ± 2.1 versus 4.7 ± 2.0; p = 0.008). Furthermore, the inter-atrial and intra-atrial electromechanical delay also significantly decreased after 3 months of metformin monotherapy (23.6 ± 8.2 versus 18.1 ± 5.8; p < 0.001, 9.1 ± 2.9 versus 6.3 ± 3.6; p = 0.003, respectively).Conclusion:In this study, we show that metformin monotherapy significantly decreases epicardial adipose tissue thickness and electromechanical delay in obese children.





2015 ◽  
Vol 45 (3) ◽  
pp. 210 ◽  
Author(s):  
Erdal Belen ◽  
Aleks Değirmencioğlu ◽  
Ertuğrul Zencirci ◽  
Fatih Fahri Tipi ◽  
Özgür Altun ◽  
...  








2013 ◽  
Vol 62 (18) ◽  
pp. C159-C160
Author(s):  
Ferit Böyük ◽  
Bülent Özdemir ◽  
Saim Sağ ◽  
Tunay Şentürk ◽  
Aysel Aydın Kaderli ◽  
...  


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