A case of bilateral limbic and recurrent unilateral cortical encephalitis with anti-myelin oligodendrocyte glycoprotein antibody positivity

A patient having clinical features reminiscent of anterior cord syndrome (ACS) was found to have long segment myelitis on MRI. Investigations revealed serum anti-myelin oligodendrocyte glycoprotein (MOG) antibody positivity. He was treated with pulse methylprednisolone followed by immunosuppressant therapy with mycophenolate mofetil, which led to clinical recovery. Anterior cord syndrome has so far not been reported in the context of anti-MOG antibody associated disease.

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Retinal nerve fiber layer and ganglion cell inner plexiform layer in youth with serum myelin oligodendrocyte glycoprotein antibody positivity

10.26226/morressier.5b719e435aff74008ae4cbf7 ◽

2018 ◽

Author(s):

E. Ann Yeh

Keyword(s):

Ganglion Cell ◽

Nerve Fiber ◽

Retinal Nerve Fiber Layer ◽

Plexiform Layer ◽

Myelin Oligodendrocyte Glycoprotein ◽

Inner Plexiform Layer ◽

Fiber Layer ◽

Nerve Fiber Layer ◽

Antibody Positivity ◽

Retinal Nerve Fiber

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104 Overlapping autoimmunity: a case of concomitant aquaporin-4 and myelin oligodendrocyte glycoprotein (MOG) antibody positivity in neuromyelitis optica spectrum disorder

10.1136/bmjno-2021-anzan.104 ◽

2021 ◽

Author(s):

Miriam Wronski ◽

Justine J Wang

Keyword(s):

Neuromyelitis Optica ◽

Myelin Oligodendrocyte Glycoprotein ◽

Spectrum Disorder ◽

Aquaporin 4 ◽

Neuromyelitis Optica Spectrum Disorder ◽

Antibody Positivity

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O27 – 2082 Anti-myelin oligodendrocyte glycoprotein antibody positivity in children with demyelinating episodes

European Journal of Paediatric Neurology ◽

10.1016/s1090-3798(13)70029-1 ◽

2013 ◽

Vol 17 ◽

pp. S9

Author(s):

SE Hughes ◽

S James ◽

P Flynn ◽

G Smyth ◽

S McKinstry ◽

...

Keyword(s):

Myelin Oligodendrocyte Glycoprotein ◽

Antibody Positivity

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Myelin oligodendrocyte glycoprotein (MOG) induces disease in the EAE-resistant BN rat: Synergy of an autoaggressive T cell response with autoantibodies to MOG

Immunology Letters ◽

10.1016/s0165-2478(97)88322-8 ◽

1997 ◽

Vol 56 (1-3) ◽

pp. 367

Author(s):

A Stefferl

Keyword(s):

T Cell ◽

Cell Response ◽

Myelin Oligodendrocyte Glycoprotein ◽

T Cell Response

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Anti-Myelin Oligodendrocyte Glycoprotein Encephalomyelitis and Extensive Longitudinal Transverse Myelitis Associated with Compound Heterozygous NLRP3 Missense Mutations in a Young Child

Journal of Pediatric Neurology ◽

10.1055/s-0040-1721434 ◽

2020 ◽

Author(s):

Deirdre O'Sullivan ◽

Michael Moore ◽

Susan Byrne ◽

Andreas O. Reiff ◽

Susanna Felsenstein

Keyword(s):

Young Child ◽

Genetic Basis ◽

Transverse Myelitis ◽

Acute Disseminated Encephalomyelitis ◽

Myelin Oligodendrocyte Glycoprotein ◽

Compound Heterozygous ◽

Missense Mutations ◽

Childhood Onset

AbstractAcute disseminated encephalomyelitis in association with extensive longitudinal transverse myelitis is reported in a young child with positive anti-myelin oligodendrocyte glycoprotein (MOG) antibody with heterozygous NLRP3 missense mutations; p.(Arg488Lys) and p.(Ser159Ile). This case may well present an exceptional coincidence, but may describe a yet unrecognized feature of the spectrum of childhood onset cryopyrinopathies that contribute to the understanding of the genetic basis for anti-MOG antibody positive encephalomyelitis. Based on this observation, a larger scale study investigating the role of NLRP3 and other inflammasomes in this entity would provide important pathophysiological insights and potentially novel avenues for treatment.

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