Developmental exposure to chlorpyrifos and diazinon differentially affect passive avoidance performance and nitric oxide synthase-containing neurons in the basolateral complex of the amygdala

7-Nitro indazole (7-NI), which is selective for the neuronal isoform of nitric oxide synthase (NOS), was tested in a passive avoidance task in the chick. Injection of 50 mg/kg i.p. pretraining had amnesic effects for the task when tested 30 min, 2 or 24 hr after training. Injections post-training had no effect. Because 7-NI does not inhibit the endothelial isoform of NOS, it does not affect blood vessel relaxation, as nonspecific inhibitors do. This effect on blood vessels could explain the amnestic effects produced by nonspecific NOS inhibitors. The results support the theory that NO is a neuronal transmitter that is important in processes of synaptic plasticity and learning.

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Alterations in nitric oxide synthase-expressing neurons in the forebrain regions of rats after developmental exposure to organophosphates

Neurotoxicology and Teratology ◽

10.1016/j.ntt.2013.02.003 ◽

2013 ◽

Vol 37 ◽

pp. 23-32 ◽

Cited By ~ 7

Author(s):

Maryam Naseh ◽

Jafar Vatanparast ◽

Mansoureh Baniasadi ◽

Gholam Ali Hamidi

Keyword(s):

Nitric Oxide ◽

Nitric Oxide Synthase ◽

Developmental Exposure ◽

Oxide Synthase

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7-Nitroindazole, a neuronal nitric oxide synthase inhibitor, impairs passive-avoidance and elevated plus-maze memory performance in rats

Pharmacology Biochemistry and Behavior ◽

10.1016/j.pbb.2007.05.019 ◽

2007 ◽

Vol 87 (4) ◽

pp. 434-443 ◽

Cited By ~ 34

Author(s):

Furuzan Yildiz Akar ◽

Guner Ulak ◽

Pelin Tanyeri ◽

Faruk Erden ◽

Tijen Utkan ◽

...

Keyword(s):

Nitric Oxide ◽

Nitric Oxide Synthase ◽

Passive Avoidance ◽

Elevated Plus Maze ◽

Memory Performance ◽

Neuronal Nitric Oxide Synthase ◽

Nitric Oxide Synthase Inhibitor ◽

Plus Maze ◽

Synthase Inhibitor ◽

Oxide Synthase

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Localization of endothelial nitric oxide synthase in the normal and failing human atrial myocardium

Proceedings, annual meeting, Electron Microscopy Society of America ◽

10.1017/s0424820100166397 ◽

1996 ◽

Vol 54 ◽

pp. 786-787

Author(s):

Chi-Ming Wei ◽

Margarita Bracamonte ◽

Shi-Wen Jiang ◽

Richard C. Daly ◽

Christopher G.A. McGregor ◽

...

Keyword(s):

Nitric Oxide ◽

Heart Failure ◽

Nitric Oxide Synthase ◽

Endothelial Nitric Oxide Synthase ◽

Cardiac Tissues ◽

Mammalian Tissues ◽

End Stage Heart Failure ◽

End Stage ◽

Oxide Synthase ◽

Endothelial Nitric Oxide

Nitric oxide (NO) is a potent endothelium-derived relaxing factor which also may modulate cardiomyocyte inotropism and growth via increasing cGMP. While endothelial nitric oxide synthase (eNOS) isoforms have been detected in non-human mammalian tissues, expression and localization of eNOS in the normal and failing human myocardium are poorly defined. Therefore, the present study was designed to investigate eNOS in human cardiac tissues in the presence and absence of congestive heart failure (CHF).Normal and failing atrial tissue were obtained from six cardiac donors and six end-stage heart failure patients undergoing primary cardiac transplantation. ENOS protein expression and localization was investigated utilizing Western blot analysis and immunohistochemical staining with the polyclonal rabbit antibody to eNOS (Transduction Laboratories, Lexington, Kentucky).

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