Deep brain stimulation of the anterior nucleus of the thalamus reverses the gene expression of cytokines and their receptors as well as neuronal degeneration in epileptic rats

2017 ◽  
Vol 1657 ◽  
pp. 304-311 ◽  
Author(s):  
Ying-Chuan Chen ◽  
Guan-Yu Zhu ◽  
Xiu Wang ◽  
Lin Shi ◽  
Yin Jiang ◽  
...  
2018 ◽  
Vol 45 (2) ◽  
pp. E5 ◽  
Author(s):  
James J. Zhou ◽  
Tsinsue Chen ◽  
S. Harrison Farber ◽  
Andrew G. Shetter ◽  
Francisco A. Ponce

OBJECTIVEThe field of deep brain stimulation (DBS) for epilepsy has grown tremendously since its inception in the 1970s and 1980s. The goal of this review is to identify and evaluate all studies published on the topic of open-loop DBS for epilepsy over the past decade (2008 to present).METHODSA PubMed search was conducted to identify all articles reporting clinical outcomes of open-loop DBS for the treatment of epilepsy published since January 1, 2008. The following composite search terms were used: (“epilepsy” [MeSH] OR “seizures” [MeSH] OR “kindling, neurologic” [MeSH] OR epilep* OR seizure* OR convuls*) AND (“deep brain stimulation” [MeSH] OR “deep brain stimulation” OR “DBS”) OR (“electric stimulation therapy” [MeSH] OR “electric stimulation therapy” OR “implantable neurostimulators” [MeSH]).RESULTSThe authors identified 41 studies that met the criteria for inclusion. The anterior nucleus of the thalamus, centromedian nucleus of the thalamus, and hippocampus were the most frequently evaluated targets. Among the 41 articles, 19 reported on stimulation of the anterior nucleus of the thalamus, 6 evaluated stimulation of the centromedian nucleus of the thalamus, and 9 evaluated stimulation of the hippocampus. The remaining 7 articles reported on the evaluation of alternative DBS targets, including the posterior hypothalamus, subthalamic nucleus, ventral intermediate nucleus of the thalamus, nucleus accumbens, caudal zone incerta, mammillothalamic tract, and fornix. The authors evaluated each study for overall epilepsy response rates as well as adverse events and other significant, nonepilepsy outcomes.CONCLUSIONSLevel I evidence supports the safety and efficacy of stimulating the anterior nucleus of the thalamus and the hippocampus for the treatment of medically refractory epilepsy. Level III and IV evidence supports stimulation of other targets for epilepsy. Ongoing research into the efficacy, adverse effects, and mechanisms of open-loop DBS continues to expand the knowledge supporting the use of these treatment modalities in patients with refractory epilepsy.


2018 ◽  
Vol 42 (2) ◽  
pp. 287-296 ◽  
Author(s):  
Tim A. M. Bouwens van der Vlis ◽  
Olaf E. M. G. Schijns ◽  
Frédéric L. W. V. J. Schaper ◽  
Govert Hoogland ◽  
Pieter Kubben ◽  
...  

PLoS ONE ◽  
2016 ◽  
Vol 11 (8) ◽  
pp. e0160750 ◽  
Author(s):  
Mohammad Maarouf ◽  
Clemens Neudorfer ◽  
Faycal El Majdoub ◽  
Doris Lenartz ◽  
Jens Kuhn ◽  
...  

2019 ◽  
Vol 153 ◽  
pp. 1-6 ◽  
Author(s):  
Yu-Chi Wang ◽  
Sanjeet S. Grewal ◽  
Erik H. Middlebrooks ◽  
Gregory A. Worrell ◽  
Matt Stead ◽  
...  

2014 ◽  
Vol 220 (5) ◽  
pp. 3061-3066 ◽  
Author(s):  
J. A. D. Dela Cruz ◽  
S. Hescham ◽  
B. Adriaanse ◽  
F. L. Campos ◽  
H. W. M. Steinbusch ◽  
...  

2019 ◽  
Vol 147 ◽  
pp. 133-139 ◽  
Author(s):  
Christiane Gimenes ◽  
Jackeline Moraes Malheiros ◽  
Harsha Battapady ◽  
Alberto Tannus ◽  
Clement Hamani ◽  
...  

2020 ◽  
Vol 136 ◽  
pp. 357-363.e2 ◽  
Author(s):  
Erik H. Middlebrooks ◽  
Chen Lin ◽  
Lela Okromelidze ◽  
Chun-Qiang Lu ◽  
William O. Tatum ◽  
...  

2008 ◽  
Vol 78 (2-3) ◽  
pp. 117-123 ◽  
Author(s):  
Clement Hamani ◽  
Mojgan Hodaie ◽  
Jason Chiang ◽  
Martin del Campo ◽  
Danielle M. Andrade ◽  
...  

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