scholarly journals Detailed neuronal distribution of GPR3 and its co-expression with EF-hand calcium-binding proteins in the mouse central nervous system

2021 ◽  
Vol 1750 ◽  
pp. 147166
Author(s):  
Fumiaki Ikawa ◽  
Shigeru Tanaka ◽  
Kana Harada ◽  
Izumi Hide ◽  
Hirofumi Maruyama ◽  
...  
Keyword(s):  
Central Nervous System ◽  
Nervous System ◽  
Calcium Binding ◽  
Binding Proteins ◽  
Calcium Binding Proteins ◽  
Ef Hand ◽  
Neuronal Distribution ◽  
Mouse Central Nervous System

scholarly journals Calcium-Binding Proteins as Determinants of Central Nervous System Neuronal Vulnerability to Disease

2019 ◽  
Vol 20 (9) ◽  
pp. 2146 ◽  
Author(s):  
Richard Fairless ◽  
Sarah K. Williams ◽  
Ricarda Diem
Keyword(s):  
Central Nervous System ◽  
Nervous System ◽  
Intracellular Calcium ◽  
Calcium Binding ◽  
Binding Proteins ◽  
Calcium Binding Proteins ◽  
First Line ◽  
Ef Hand ◽  
Key Factor

Neuronal subpopulations display differential vulnerabilities to disease, but the factors that determine their susceptibility are poorly understood. Toxic increases in intracellular calcium are a key factor in several neurodegenerative processes, with calcium-binding proteins providing an important first line of defense through their ability to buffer incoming calcium, allowing the neuron to quickly achieve homeostasis. Since neurons expressing different calcium-binding proteins have been reported to be differentially susceptible to degeneration, it can be hypothesized that rather than just serving as markers of different neuronal subpopulations, they might actually be a key determinant of survival. In this review, we will summarize some of the evidence that expression of the EF-hand calcium-binding proteins, calbindin, calretinin and parvalbumin, may influence the susceptibility of distinct neuronal subpopulations to disease processes.

scholarly journals New Approach for Untangling the Role of Uncommon Calcium-Binding Proteins in the Central Nervous System

2021 ◽  
Vol 11 (5) ◽  
pp. 634
Author(s):  
Krisztina Kelemen ◽  
Tibor Szilágyi
Keyword(s):  
Gene Expression ◽  
Central Nervous System ◽  
Nervous System ◽  
Calcium Binding ◽  
Binding Proteins ◽  
Expression Profiles ◽  
Calcium Binding Proteins ◽  
Brain Atlas ◽  
Specific Cell ◽  
The Central Nervous System

Although Ca2+ ion plays an essential role in cellular physiology, calcium-binding proteins (CaBPs) were long used for mainly as immunohistochemical markers of specific cell types in different regions of the central nervous system. They are a heterogeneous and wide-ranging group of proteins. Their function was studied intensively in the last two decades and a tremendous amount of information was gathered about them. Girard et al. compiled a comprehensive list of the gene-expression profiles of the entire EF-hand gene superfamily in the murine brain. We selected from this database those CaBPs which are related to information processing and/or neuronal signalling, have a Ca2+-buffer activity, Ca2+-sensor activity, modulator of Ca2+-channel activity, or a yet unknown function. In this way we created a gene function-based selection of the CaBPs. We cross-referenced these findings with publicly available, high-quality RNA-sequencing and in situ hybridization databases (Human Protein Atlas (HPA), Brain RNA-seq database and Allen Brain Atlas integrated into the HPA) and created gene expression heat maps of the regional and cell type-specific expression levels of the selected CaBPs. This represents a useful tool to predict and investigate different expression patterns and functions of the less-known CaBPs of the central nervous system.

scholarly journals S100A14, a Member of the EF-hand Calcium-binding Proteins, Is Overexpressed in Breast Cancer and Acts as a Modulator of HER2 Signaling

2013 ◽  
Vol 289 (2) ◽  
pp. 827-837 ◽  
Author(s):  
Chengshan Xu ◽  
Hongyan Chen ◽  
Xiang Wang ◽  
Jidong Gao ◽  
Yiqun Che ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Calcium Binding ◽  
Binding Proteins ◽  
Calcium Binding Proteins ◽  
Ef Hand ◽  
Her2 Signaling
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