Neuro-cognitive effects of Hf-rTMS over the right versus left dorsolateral prefrontal cortex on the attentional modulation of emotional information in healthy subjects: an event-related fMRI-study

2008 ◽  
Vol 1 (3) ◽  
pp. 291
Author(s):  
R. De Raedt ◽  
L. Leyman ◽  
U. Dannlowski ◽  
M. Vanderhasselt ◽  
R. Luypaert ◽  
...  
Keyword(s):  
Prefrontal Cortex ◽  
Healthy Subjects ◽  
Dorsolateral Prefrontal Cortex ◽  
Cognitive Effects ◽  
Attentional Modulation ◽  
Emotional Information ◽  
Fmri Study ◽  
Dorsolateral Prefrontal ◽  
The Right

scholarly journals Mechanistic link between right prefrontal cortical activity and anxious arousal revealed using transcranial magnetic stimulation in healthy subjects

2019 ◽  
Vol 45 (4) ◽  
pp. 694-702 ◽  
Author(s):  
Nicholas L. Balderston ◽  
Emily M. Beydler ◽  
Camille Roberts ◽  
Zhi-De Deng ◽  
Thomas Radman ◽  
...  
Keyword(s):  
Prefrontal Cortex ◽  
Transcranial Magnetic Stimulation ◽  
Healthy Subjects ◽  
Magnetic Stimulation ◽  
Dorsolateral Prefrontal Cortex ◽  
Subcortical Structures ◽  
Prefrontal Cortical ◽  
Dorsolateral Prefrontal ◽  
Before And After ◽  
The Right

AbstractMuch of the mechanistic research on anxiety focuses on subcortical structures such as the amygdala; however, less is known about the distributed cortical circuit that also contributes to anxiety expression. One way to learn about this circuit is to probe candidate regions using transcranial magnetic stimulation (TMS). In this study, we tested the involvement of the dorsolateral prefrontal cortex (dlPFC), in anxiety expression using 10 Hz repetitive TMS (rTMS). In a within-subject, crossover experiment, the study measured anxiety in healthy subjects before and after a session of 10 Hz rTMS to the right dorsolateral prefrontal cortex (dlPFC). It used threat of predictable and unpredictable shock to induce anxiety and anxiety potentiated startle to assess anxiety. Counter to our hypotheses, results showed an increase in anxiety-potentiated startle following active but not sham rTMS. These results suggest a mechanistic link between right dlPFC activity and physiological anxiety expression. This result supports current models of prefrontal asymmetry in affect, and lays the groundwork for further exploration into the cortical mechanisms mediating anxiety, which may lead to novel anxiety treatments.

scholarly journals Effects of Mindfulness Training on Emotion Regulation in Patients with Depression: Reduced Dorsolateral Prefrontal Cortex Activation Indexes Early Beneficial Changes

2019 ◽  
Author(s):  
Thorsten Barnhofer ◽  
Tim Reess ◽  
Maria Fissler ◽  
Emilia Winnebeck ◽  
Simone Grimm ◽  
...  
Keyword(s):  
Emotion Regulation ◽  
Prefrontal Cortex ◽  
Dorsolateral Prefrontal Cortex ◽  
Negative Mood ◽  
Affective Stimuli ◽  
Fmri Study ◽  
Dorsolateral Prefrontal ◽  
Before And After ◽  
Highly Correlated ◽  
The Right

Mindfulness-based interventions (MBI) have been found to be a promising approach for the treatment of recurrent courses of depression. However, little is known about their neural mechanisms. This fMRI study set out to investigate activation changes in fronto-limbic regions during implicit emotion regulation. Depressed patients with a recurrent lifetime history were randomized to receive a two-week MBI (N=16 completers) or psycho-education and resting (PER, N=22 completers). Before and after, patients underwent fMR imaging while labelling the affect of angry, happy, and neutral facial expressions and completed questionnaires assessing ruminative brooding, the ability to decentre from such thinking, and depressive symptoms. Activation decreased in the right dorsolateral prefrontal cortex (dlPFC) in response to angry faces following MBI, but not following PER. This change was highly correlated with increased decentering, decreased brooding and decreased symptoms. Amygdala activation in response to happy faces decreased following PER, while the MBI group showed a small but insignificant increase. The dlPFC is involved in emotion regulation, namely reappraisal or suppression of negative emotions. Decreased right dlPFC activation might indicate that, following the MBI, patients abstained from engaging in elaboration or suppression of negative affective stimuli; a putatively important mechanism for preventing the escalation of negative mood.

scholarly journals Null Effect of Transcranial Static Magnetic Field Stimulation over the Dorsolateral Prefrontal Cortex on Behavioral Performance in a Go/NoGo Task

2021 ◽  
Vol 11 (4) ◽  
pp. 483
Author(s):  
Tatsunori Watanabe ◽  
Nami Kubo ◽  
Xiaoxiao Chen ◽  
Keisuke Yunoki ◽  
Takuya Matsumoto ◽  
...  
Keyword(s):  
Magnetic Field ◽  
Prefrontal Cortex ◽  
Inhibitory Control ◽  
Static Magnetic Field ◽  
Dorsolateral Prefrontal Cortex ◽  
Cortical Excitability ◽  
Control Function ◽  
Field Stimulation ◽  
Dorsolateral Prefrontal ◽  
The Right

The purpose of this pilot study was to investigate whether transcranial static magnetic field stimulation (tSMS), which can modulate cortical excitability, would influence inhibitory control function when applied over the dorsolateral prefrontal cortex (DLPFC). Young healthy adults (n = 8, mean age ± SD = 24.4 ± 4.1, six females) received the following stimulations for 30 min on different days: (1) tSMS over the left DLPFC, (2) tSMS over the right DLPFC, and (3) sham stimulation over either the left or right DLPFC. The participants performed a Go/NoGo task before, immediately after, and 10 min after the stimulation. They were instructed to extend the right wrist in response to target stimuli. We recorded the electromyogram from the right wrist extensor muscles and analyzed erroneous responses (false alarm and missed target detection) and reaction times. As a result, 50% of the participants made erroneous responses, and there were five erroneous responses in total (0.003%). A series of statistical analyses revealed that tSMS did not affect the reaction time. These preliminary findings suggest the possibility that tSMS over the DLPFC is incapable of modulating inhibitory control and/or that the cognitive load imposed in this study was insufficient to detect the effect.

scholarly journals Single-Pulse Transcranial Magnetic Stimulation-Evoked Potential Amplitudes and Latencies in the Motor and Dorsolateral Prefrontal Cortex among Young, Older Healthy Participants, and Schizophrenia Patients

2021 ◽  
Vol 11 (1) ◽  
pp. 54
Author(s):  
Yoshihiro Noda ◽  
Mera S. Barr ◽  
Reza Zomorrodi ◽  
Robin F. H. Cash ◽  
Pantelis Lioumis ◽  
...  
Keyword(s):  
Prefrontal Cortex ◽  
Transcranial Magnetic Stimulation ◽  
Magnetic Stimulation ◽  
Dorsolateral Prefrontal Cortex ◽  
Evoked Potential ◽  
Single Pulse ◽  
Signal Propagation ◽  
Lower Amplitude ◽  
Dorsolateral Prefrontal ◽  
The Right

Background: The combination of transcranial magnetic stimulation (TMS) with electroencephalography (EEG) allows for non-invasive investigation of cortical response and connectivity in human cortex. This study aimed to examine the amplitudes and latencies of each TMS-evoked potential (TEP) component induced by single-pulse TMS (spTMS) to the left motor (M1) and dorsolateral prefrontal cortex (DLPFC) among healthy young participants (YNG), older participants (OLD), and patients with schizophrenia (SCZ). Methods: We compared the spatiotemporal characteristics of TEPs induced by spTMS among the groups. Results: Compared to YNG, M1-spTMS induced lower amplitudes of N45 and P180 in OLD and a lower amplitude of P180 in SCZ, whereas the DLPFC-spTMS induced a lower N45 in OLD. Further, OLD demonstrated latency delays in P60 after M1-spTMS and in N45-P60 over the right central region after left DLPFC-spTMS, whereas SCZ demonstrated latency delays in N45-P60 over the midline and right central regions after DLPFC-spTMS. Conclusions: These findings suggest that inhibitory and excitatory mechanisms mediating TEPs may be altered in OLD and SCZ. The amplitude and latency changes of TEPs with spTMS may reflect underlying neurophysiological changes in OLD and SCZ, respectively. The spTMS administered to M1 and the DLPFC can probe cortical functions by examining TEPs. Thus, TMS-EEG can be used to study changes in cortical connectivity and signal propagation from healthy to pathological brains.

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