Anodal tDCS over the right dorsolateral prefrontal cortex modulates cognitive processing of emotional information as a function of trait rumination in healthy volunteers

2017 ◽  
Vol 123 ◽  
pp. 111-118 ◽  
Author(s):  
Marie-Anne Vanderhasselt ◽  
Alvaro Sanchez ◽  
Haeike Josephy ◽  
Chris Baeken ◽  
Andre R. Brunoni ◽  
...  
Keyword(s):  
Prefrontal Cortex ◽  
Healthy Volunteers ◽  
Cognitive Processing ◽  
Dorsolateral Prefrontal Cortex ◽  
Anodal Tdcs ◽  
Emotional Information ◽  
Dorsolateral Prefrontal ◽  
The Right

scholarly journals Efficiency of Repetitive Transcranial Direct Current Stimulation of the Dorsolateral Prefrontal Cortex in Disorders of Consciousness: A Randomized Sham-Controlled Study

2019 ◽  
Vol 2019 ◽  
pp. 1-11 ◽  
Author(s):  
Min Wu ◽  
Yamei Yu ◽  
Lunjie Luo ◽  
Yuehao Wu ◽  
Jian Gao ◽  
...  
Keyword(s):  
Prefrontal Cortex ◽  
Direct Current ◽  
Transcranial Direct Current Stimulation ◽  
Dorsolateral Prefrontal Cortex ◽  
Disorders Of Consciousness ◽  
Anodal Tdcs ◽  
Direct Current Stimulation ◽  
Dorsolateral Prefrontal ◽  
The Right ◽  
Stimulation Of

Conventional transcranial direct current stimulation (tDCS) targeting the left dorsolateral prefrontal cortex (DLPFC) could improve arousal in disorders of consciousness (DOC). However, the comparative effectiveness of anodal stimulation of the left DLPFC and the electrophysiological effect of tDCS are yet to be determined. In this randomized sham-controlled design, patients were separated into three groups (left/right anodal tDCS, sham). Data on the clinical assessments and EEG were collected at baseline and after 2 weeks of tDCS. The outcome at 3-month follow-up was evaluated using the Glasgow Outcome Scale-Extended. Results showed that sessions of the left tDCS facilitated the excitability of the prefrontal cortex, whereas only one patient had a positive outcome. Targeting the right DLPFC was less effective, merely leading to activation of the stimulation site, with no effect on the state of arousal. Moreover, sham stimulation had minimal or no effect on any of the outcomes. These results provide evidence for a hemispheric asymmetry of tDCS effects in patients with DOC. Left anodal tDCS might be more effective for modulating cortical excitability compared to tDCS on the right DLPFC. However, future studies with large sample sizes are needed to confirm these findings. This trial is registered with NCT03809936.

scholarly journals Anodal Transcranial Direct Current Stimulation-Induced Effects Over the Right Dorsolateral Prefrontal Cortex: Differences in the Task Types of Task Switching

2021 ◽  
Vol 12 ◽  
Author(s):  
Ziyu Wang ◽  
Rongjuan Zhu ◽  
Xuqun You
Keyword(s):  
Prefrontal Cortex ◽  
Task Switching ◽  
Dorsolateral Prefrontal Cortex ◽  
Switch Cost ◽  
Sham Group ◽  
Anodal Tdcs ◽  
Dorsolateral Prefrontal ◽  
The Right ◽  
Task Types ◽  
And Task

Transcranial direct current stimulation (tDCS) has been previously used to investigate the causal relationships between the dorsolateral prefrontal cortex (DLPFC) and task switching but has delivered inconclusive results that may be due to different switching tasks involving different cognitive control processes. In the current study, we manipulated task types and task predictability to investigate the role of DLPFC in task-switching performances. Notably, we distinguished the specific effects of anodal-tDCS on two types of tasks (parity/magnitude and parity/vowel-consonant tasks). Forty-eight participants were randomly assigned to four task groups as follows; Group I who was assigned right anode (RA) parity/magnitude tasks, Group II who were assigned sham parity/magnitude tasks, Group III who were assigned RA parity/vowel-consonant tasks, and Group IV who were assigned sham parity/vowel-consonant tasks. Participants were asked to complete both predictable and unpredictable tasks. In the parity/magnitude task, we demonstrated a lower switch cost for the RA group compared to the sham group for unpredictable tasks. In contrast, in the parity/vowel-consonant task, the switch cost was higher for the RA group compared to the sham group for unpredictable and predictable tasks. These findings confirmed an anodal-tDCS-induced effect over the right DLPFC both in the parity/magnitude and parity/vowel-consonant tasks. Our data indicated that anodal tDCS may have a stronger influence on task-switching performance over the right DLPFC by changing the irrelevant task-set inhibition process. Also, the right DLPFC is unlikely to act by performing exogenous adjustment of predictable task switching.

scholarly journals Involvement of the Right Dorsolateral Prefrontal Cortex in Numerical Rule Induction: A Transcranial Direct Current Stimulation Study

2020 ◽  
Vol 14 ◽  
Author(s):  
Yuzhao Yao ◽  
Xiuqin Jia ◽  
Jun Luo ◽  
Feiyan Chen ◽  
Peipeng Liang
Keyword(s):  
Prefrontal Cortex ◽  
Direct Current ◽  
Transcranial Direct Current Stimulation ◽  
Dorsolateral Prefrontal Cortex ◽  
Critical Role ◽  
Inductive Reasoning ◽  
Anodal Tdcs ◽  
Direct Current Stimulation ◽  
Dorsolateral Prefrontal ◽  
The Right

Numerical inductive reasoning has been considered as one of the most important higher cognitive functions of the human brain. Importantly, previous behavioral studies have consistently reported that one critical component of numerical inductive reasoning is checking, which often occurs when a discrepant element is discovered, and reprocessing is needed to determine whether the discrepancy is an error of the original series. However, less is known about the neural mechanism underlying the checking process. Given that the checking effect involves cognitive control processes, such as the incongruent resolution, that are linked to the right dorsolateral prefrontal cortex (DLPFC), this study hypothesizes that the right DLPFC may play a specific role in the checking process. To test the hypothesis, this study utilized the transcranial direct current stimulation (tDCS), a non-invasive brain stimulation method that could modulate cortical excitability, and examined whether and how the stimulation of the right DLPFC via tDCS could modulate the checking effect during a number-series completion problem task. Ninety healthy participants were allocated to one of the anodal, cathodal, and sham groups. Subjects were required to verify whether number sequences formed rule-based series, and checking effect was assessed by the difference in performance between invalid and valid conditions. It was found that significantly longer response times (RTs) were exhibited in invalid condition compared with valid condition in groups of anodal, cathodal, and sham tDCS. Furthermore, the anodal tDCS significantly shortened the checking effect than those of the cathodal and sham groups, whereas no significantly prolonged checking effect was detected in the cathodal group. The current findings indicated that anodal tDCS affected the process of checking, which suggested that the right DLPFC might play a critical role in the checking process of numerical inductive reasoning by inhibiting incongruent response.

scholarly journals Null Effect of Transcranial Static Magnetic Field Stimulation over the Dorsolateral Prefrontal Cortex on Behavioral Performance in a Go/NoGo Task

2021 ◽  
Vol 11 (4) ◽  
pp. 483
Author(s):  
Tatsunori Watanabe ◽  
Nami Kubo ◽  
Xiaoxiao Chen ◽  
Keisuke Yunoki ◽  
Takuya Matsumoto ◽  
...  
Keyword(s):  
Magnetic Field ◽  
Prefrontal Cortex ◽  
Inhibitory Control ◽  
Static Magnetic Field ◽  
Dorsolateral Prefrontal Cortex ◽  
Cortical Excitability ◽  
Control Function ◽  
Field Stimulation ◽  
Dorsolateral Prefrontal ◽  
The Right

The purpose of this pilot study was to investigate whether transcranial static magnetic field stimulation (tSMS), which can modulate cortical excitability, would influence inhibitory control function when applied over the dorsolateral prefrontal cortex (DLPFC). Young healthy adults (n = 8, mean age ± SD = 24.4 ± 4.1, six females) received the following stimulations for 30 min on different days: (1) tSMS over the left DLPFC, (2) tSMS over the right DLPFC, and (3) sham stimulation over either the left or right DLPFC. The participants performed a Go/NoGo task before, immediately after, and 10 min after the stimulation. They were instructed to extend the right wrist in response to target stimuli. We recorded the electromyogram from the right wrist extensor muscles and analyzed erroneous responses (false alarm and missed target detection) and reaction times. As a result, 50% of the participants made erroneous responses, and there were five erroneous responses in total (0.003%). A series of statistical analyses revealed that tSMS did not affect the reaction time. These preliminary findings suggest the possibility that tSMS over the DLPFC is incapable of modulating inhibitory control and/or that the cognitive load imposed in this study was insufficient to detect the effect.

scholarly journals Single-Pulse Transcranial Magnetic Stimulation-Evoked Potential Amplitudes and Latencies in the Motor and Dorsolateral Prefrontal Cortex among Young, Older Healthy Participants, and Schizophrenia Patients

2021 ◽  
Vol 11 (1) ◽  
pp. 54
Author(s):  
Yoshihiro Noda ◽  
Mera S. Barr ◽  
Reza Zomorrodi ◽  
Robin F. H. Cash ◽  
Pantelis Lioumis ◽  
...  
Keyword(s):  
Prefrontal Cortex ◽  
Transcranial Magnetic Stimulation ◽  
Magnetic Stimulation ◽  
Dorsolateral Prefrontal Cortex ◽  
Evoked Potential ◽  
Single Pulse ◽  
Signal Propagation ◽  
Lower Amplitude ◽  
Dorsolateral Prefrontal ◽  
The Right

Background: The combination of transcranial magnetic stimulation (TMS) with electroencephalography (EEG) allows for non-invasive investigation of cortical response and connectivity in human cortex. This study aimed to examine the amplitudes and latencies of each TMS-evoked potential (TEP) component induced by single-pulse TMS (spTMS) to the left motor (M1) and dorsolateral prefrontal cortex (DLPFC) among healthy young participants (YNG), older participants (OLD), and patients with schizophrenia (SCZ). Methods: We compared the spatiotemporal characteristics of TEPs induced by spTMS among the groups. Results: Compared to YNG, M1-spTMS induced lower amplitudes of N45 and P180 in OLD and a lower amplitude of P180 in SCZ, whereas the DLPFC-spTMS induced a lower N45 in OLD. Further, OLD demonstrated latency delays in P60 after M1-spTMS and in N45-P60 over the right central region after left DLPFC-spTMS, whereas SCZ demonstrated latency delays in N45-P60 over the midline and right central regions after DLPFC-spTMS. Conclusions: These findings suggest that inhibitory and excitatory mechanisms mediating TEPs may be altered in OLD and SCZ. The amplitude and latency changes of TEPs with spTMS may reflect underlying neurophysiological changes in OLD and SCZ, respectively. The spTMS administered to M1 and the DLPFC can probe cortical functions by examining TEPs. Thus, TMS-EEG can be used to study changes in cortical connectivity and signal propagation from healthy to pathological brains.

scholarly journals Influence of Atomoxetine on Relationship Between ADHD Symptoms and Prefrontal Cortex Activity During Task Execution in Adult Patients

2021 ◽  
Vol 15 ◽  
Author(s):  
Atsunori Sugimoto ◽  
Yutaro Suzuki ◽  
Kiyohiro Yoshinaga ◽  
Naoki Orime ◽  
Taketsugu Hayashi ◽  
...  
Keyword(s):  
Prefrontal Cortex ◽  
Dorsolateral Prefrontal Cortex ◽  
Rating Scales ◽  
Clinical Symptoms ◽  
Adult Patients ◽  
Adhd Symptoms ◽  
Analytical Strategy ◽  
Positive Correlation ◽  
Dorsolateral Prefrontal ◽  
The Right

Objective: We conducted this non-randomized prospective interventional study to clarify the relationship between improved attention-deficit hyperactivity disorder (ADHD) symptoms and regional brain activity.Methods: Thirty-one adult patients underwent near-infrared spectroscopy examinations during a go/no-go task, both before and 8 weeks after atomoxetine administration.Results: Clinical symptoms, neuropsychological results of the go/no-go task, and bilateral lateral prefrontal activity significantly changed. A positive correlation was observed between right dorsolateral prefrontal cortex activity and Conners’ Adult ADHD Rating Scales scores. Before atomoxetine administration, no correlations between prefrontal cortex activity and clinical symptoms were observed in all cases. When participants were divided into atomoxetine-responder and non-responder groups, a positive correlation was observed between prefrontal cortex activity and clinical symptoms in the non-responder group before treatment but not in the responder group, suggesting that non-responders can activate the prefrontal cortex without atomoxetine.Conclusions: Individuals with increased ADHD symptoms appear to recruit the right dorsolateral prefrontal cortex more strongly to perform the same task than those with fewer symptoms. In clinical settings, individuals with severe symptoms are often observed to perform more difficultly when performing the tasks which individuals with mild symptoms can perform easily. The atomoxetine-responder group was unable to properly activate the right dorsolateral prefrontal cortex when necessary, and the oral administration of atomoxetine enabled these patients to activate this region. In brain imaging studies of heterogeneous syndromes such as ADHD, the analytical strategy used in this study, involving drug-responsivity grouping, may effectively increase the signal-to-noise ratio.

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