Different roles of the monkey dorsolateral prefrontal, premotor and posterior parietal cortices in a delayed response task revealed by functional disturbance by on-line rTMS

2015 ◽  
Vol 8 (2) ◽  
pp. 321
Author(s):  
S. Nakamura ◽  
T. Hosokawa ◽  
T. Iijima ◽  
K.I. Tsutsui
Keyword(s):  
Delayed Response ◽  
Functional Disturbance ◽  
Dorsolateral Prefrontal ◽  
On Line ◽  
Posterior Parietal ◽  
Response Task ◽  
Parietal Cortices ◽  
Delayed Response Task

scholarly journals Behavioral effect of chemogenetic inhibition is directly related to receptor transduction levels in rhesus monkeys

2018 ◽  
Author(s):  
Nicholas A. Upright ◽  
Stephen W. Brookshire ◽  
Wendy Schnebelen ◽  
Christienne G. Damatac ◽  
Patrick R. Hof ◽  
...  
Keyword(s):  
Working Memory ◽  
Prefrontal Cortex ◽  
Rhesus Monkeys ◽  
Dorsolateral Prefrontal Cortex ◽  
Behavioral Effect ◽  
Designer Drug ◽  
Delayed Response ◽  
Dorsolateral Prefrontal ◽  
Response Task ◽  
Delayed Response Task

AbstractWe used inhibitory DREADDs (Designer Receptors Exclusively Activated by Designer Drugs) to reversibly disrupt dorsolateral prefrontal cortex (dlPFC) function in male macaque monkeys. Monkeys were tested on a spatial delayed response task to assess working memory function after intramuscular injection of either clozapine-N-oxide (CNO) or vehicle. CNO injections given before DREADD transduction were without effect on behavior. rAAV5/hsyn-hM4Di-mCherry was injected bilaterally into the dlPFC of five male rhesus monkeys, to produce neuronal expression of the inhibitory (Gi-coupled) DREADD receptor. We quantified the percentage of DREADD- transduced cells using stereological analysis of mCherry-immunolabeled cells. We found a greater number of immunolabeled neurons in monkeys that displayed CNO-induced behavioral impairment after DREADD transduction compared to monkeys that showed no behavioral effect after CNO. Even in monkeys that showed reliable effects of CNO on behavior after DREADD transduction, the number of prefrontal neurons transduced with DREADD receptor was on the order of 3% of total prefrontal neurons counted. This level of histological analysis facilitates our understanding of behavioral effects, or lack thereof, after DREADD vector injection in monkeys. It also implies that a functional silencing of a relatively small fraction of dlPFC neurons, albeit in a widely distributed area, is sufficient to disrupt spatial working memory.Significance StatementCognitive domains such as working memory and executive function are mediated by the dorsolateral prefrontal cortex (dlPFC). Impairments in these domains are common in neurodegenerative diseases as well as normal aging. The present study sought to measure deficits in a spatial delayed response task following activation of viral-vector transduced inhibitory DREADD (Designer Receptor Exclusively Activated by Designer Drug) receptors in rhesus macaques and compare this to the level of transduction in dlPFC using stereology. We found a significant relationship between the extent of DREADD transduction and the magnitude of behavioral deficit following administration of the DREADD actuator compound clozapine-N- oxide (CNO). These results demonstrate it will be critical to validate transduction to ensure DREADDs remain a powerful tool for neuronal disruption.

Extrastriate Visual Areas Contribute to the Performance of a Spatial Delayed Response Task

NeuroImage ◽  
1998 ◽  
Vol 7 (4) ◽  
pp. S343
Author(s):  
R.A. Berman ◽  
J.A. Sweeney ◽  
K.R. Thulborn ◽  
C.L. Colby
Keyword(s):  
Delayed Response ◽  
Visual Areas ◽  
Response Task ◽  
Delayed Response Task

Spatial working memory assessment by a visual-manual delayed response task: a controlled study in schizophrenia

1999 ◽  
Vol 275 (1) ◽  
pp. 9-12 ◽  
Author(s):  
P Stratta ◽  
E Daneluzzo ◽  
P Prosperini ◽  
M Bustini ◽  
M.G Marinangeli ◽  
...  
Keyword(s):  
Working Memory ◽  
Spatial Working Memory ◽  
Controlled Study ◽  
Delayed Response ◽  
Memory Assessment ◽  
Response Task ◽  
Delayed Response Task

Hyperstriatal Lesions and Short-Term Retention of Non-Visual Information in Pigeons

1985 ◽  
Vol 37 (2b) ◽  
pp. 121-153 ◽  
Author(s):  
Euan M. Macphail ◽  
Steve Reilly
Keyword(s):  
Visual Information ◽  
Delayed Response ◽  
Control Performance ◽  
Unoperated Control ◽  
Short Term ◽  
Term Retention ◽  
Central Sets ◽  
Retention Intervals ◽  
Response Task ◽  
Delayed Response Task

Short-term retention of non-visual information was investigated using three series of hyperstriatal-lesioned and unoperated control pigeons. Neither retention (Experiment 1) nor acquisition (Experiment 3) of go/no-go alternation was disrupted by the lesions. Similarly, Experiments 2 and 5 failed to detect significant disruption of either retention or acquisition of spatial alternation. Increases in the retention intervals used in these tasks reduced accuracy in both groups but did not differently affect hyperstriatal as opposed to control performance. A lasting deficit was, however, obtained in a delayed-response task (Experiment 4), but this deficit, which was independent of retention interval, appeared to be the result, not of a disruption of memory, but of an exaggerated perseverative tendency. Experiment 6 confirmed that all three series of hyperstriatal birds showed disruption of reversals of a spatial discrimination. It is concluded that hyperstriatal lesions do not disrupt memory processes, and the hypothesis that hyperstriatal damage induces perseveration of central sets is discussed.

Temporally Irregular Mnemonic Persistent Activity in Prefrontal Neurons of Monkeys During a Delayed Response Task

2003 ◽  
Vol 90 (5) ◽  
pp. 3441-3454 ◽  
Author(s):  
Albert Compte, ◽  
Christos Constantinidis ◽  
Jesper Tegnér ◽  
Sridhar Raghavachari ◽  
Matthew V. Chafee ◽  
...  
Keyword(s):  
Prefrontal Cortex ◽  
Power Spectrum ◽  
Spike Train ◽  
Temporal Structure ◽  
Spike Trains ◽  
Delay Period ◽  
Delayed Response ◽  
Persistent Activity ◽  
Response Task ◽  
Delayed Response Task

An important question in neuroscience is whether and how temporal patterns and fluctuations in neuronal spike trains contribute to information processing in the cortex. We have addressed this issue in the memory-related circuits of the prefrontal cortex by analyzing spike trains from a database of 229 neurons recorded in the dorsolateral prefrontal cortex of 4 macaque monkeys during the performance of an oculomotor delayed-response task. For each task epoch, we have estimated their power spectrum together with interspike interval histograms and autocorrelograms. We find that 1) the properties of most (about 60%) neurons approximated the characteristics of a Poisson process. For about 25% of cells, with characteristics typical of interneurons, the power spectrum showed a trough at low frequencies (<20 Hz) and the autocorrelogram a dip near zero time lag. About 15% of neurons had a peak at <20 Hz in the power spectrum, associated with the burstiness of the spike train; 2) a small but significant task dependency of spike-train temporal structure: delay responses to preferred locations were characterized not only by elevated firing, but also by suppressed power at low (<20 Hz) frequencies; and 3) the variability of interspike intervals is typically higher during the mnemonic delay period than during the fixation period, regardless of the remembered cue. The high irregularity of neural persistent activity during the delay period is likely to be a characteristic signature of recurrent prefrontal network dynamics underlying working memory.

scholarly journals Mossy fibers in the cerebellar hemisphere show delay activity in a delayed response task

2014 ◽  
Vol 87 ◽  
pp. 84-89 ◽  
Author(s):  
Takahiro Ishikawa ◽  
Saeka Tomatsu ◽  
Yoshiaki Tsunoda ◽  
Donna S. Hoffman ◽  
Shinji Kakei
Keyword(s):  
Mossy Fibers ◽  
Cerebellar Hemisphere ◽  
Delayed Response ◽  
Response Task ◽  
Delayed Response Task
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