Dual-mode Noninvasive Brain Stimulation over Prefrontal Cortices on Working Memory in Stroke Patients

2015 ◽  
Vol 8 (2) ◽  
pp. 359
Author(s):  
Ahee Lee ◽  
Won Hyuk Chang ◽  
Min Ji Lee ◽  
Min-Su Kim ◽  
Yun-Hee Kim
2017 ◽  
Vol 10 (2) ◽  
pp. 439-440 ◽  
Author(s):  
J. Lee ◽  
E. Park ◽  
A. Lee ◽  
W.H. Chang ◽  
D.S. Kim ◽  
...  

2017 ◽  
Vol 35 (1) ◽  
pp. 105-114 ◽  
Author(s):  
Jae Yong Cho ◽  
Ahee Lee ◽  
Min Su Kim ◽  
Eunhee Park ◽  
Won Hyuk Chang ◽  
...  

Stroke ◽  
2014 ◽  
Vol 45 (suppl_1) ◽  
Author(s):  
Eunhee Park ◽  
Tae Gun Kwon ◽  
Won Hyuk Chang ◽  
Yun-Hee Kim

Objective: The purpose of this study was to investigate the effect of dual-mode noninvasive brain stimulation (NBS) by combining transcranial direct current stimulation (tDCS) over the unaffected primary motor cortex (uM1) and high-frequency repetitive transcranial magnetic stimulation (rTMS) over the affected M1 (aM1) on motor functions and corticomotor excitability in chronic stroke patients. Methods: Seventeen chronic stroke patients (12 men; mean age 58.7 years; 12 infarctions and 5 hemorrhages) participated in this double blinded random-order crossover study. All participants received three randomly arranged, dual-mode stimulations with 24 hours of washout period; Condition 1, simultaneous application of 10 Hz rTMS over the aM1 and cathodal tDCS over the uM1; Condition 2, simultaneous application of 10 Hz rTMS over the M1a and anodal tDCS over the uM1; Condition 3, 10 Hz rTMS over the aM1 and sham tDCS over the uM1. Corticomotor excitability using motor evoked potential (MEP) amplitude and hand motor functions using the sequential motor task were assessed before and after stimulation. Results: MEP amplitude was significantly increased after condition 1 and 3, respectively (p<0.05). The changes of MEP amplitude were significantly higher in condition 1 than condition 2 (p<0.05). In sequential motor task, the movement time was significantly decreased after condition 1 and 3, respectively (p<0.05). The change of movement time was significantly larger in condition 1 than the other conditions (p<0.05). Conclusions: Simultaneous stimulation of cathodal tDCS over the uM1 produced enhancement of 10 Hz rTMS effect over the aM1 in patients with stroke. These results suggest the dual-mode NBS as a method of enhancing motor function probably by inducing interhemispheric interaction of bilateral primary motor cortices in chronic stroke patients (Supported by the National Research Foundation of Korea grant (No.2011-0016960) and a KOSEF grant (M10644000022-06N4400-02210)).


2018 ◽  
Vol 1423 (1) ◽  
pp. 126-137 ◽  
Author(s):  
Philippe Albouy ◽  
Sylvain Baillet ◽  
Robert J. Zatorre

2014 ◽  
Vol 38 (3) ◽  
pp. 297 ◽  
Author(s):  
Eunhee Park ◽  
Yun-Hee Kim ◽  
Won Hyuk Chang ◽  
Tae Gun Kwon ◽  
Yong-Il Shin

2012 ◽  
Vol 2012 ◽  
pp. 1-10 ◽  
Author(s):  
Naoyuki Takeuchi ◽  
Shin-Ichi Izumi

Repetitive transcranial magnetic stimulation and transcranial direct current stimulation are noninvasive brain stimulation (NIBS) techniques that can alter excitability of the human cortex. Considering the interhemispheric competition occurring after stroke, improvement in motor deficits can be achieved by increasing the excitability of the affected hemisphere or decreasing the excitability of the unaffected hemisphere. Many reports have shown that NIBS application improves motor function in stroke patients by using their physiological peculiarity. For continuous motor improvement, it is important to impart additional motor training while NIBS modulates the neural network between both hemispheres and remodels the disturbed network in the affected hemisphere. NIBS can be an adjuvant therapy for developed neurorehabilitation strategies for stroke patients. Moreover, recent studies have reported that bilateral NIBS can more effectively facilitate neural plasticity and induce motor recovery after stroke. However, the best NIBS pattern has not been established, and clinicians should select the type of NIBS by considering the NIBS mechanism. Here, we review the underlying mechanisms and future views of NIBS therapy and propose rehabilitation approaches for appropriate cortical reorganization.


2017 ◽  
Vol 98 (7) ◽  
pp. 1283-1290 ◽  
Author(s):  
Won Hyuk Chang ◽  
Min Soo Kim ◽  
Eunhee Park ◽  
Jin Whan Cho ◽  
Jinyoung Youn ◽  
...  

2017 ◽  
Vol 26 (2) ◽  
pp. 165-173 ◽  
Author(s):  
Chi-Hung Juan ◽  
Philip Tseng ◽  
Tzu-Yu Hsu

Visuospatial working memory refers to the short-term memory mechanism that enables humans to remember visual information across visual blackout periods such as eyeblinks or eye movements. In recent years, neuroscientific studies have made great progress in uncovering the brain regions that support visuospatial working memory. In this review, we focus on the role of the posterior parietal cortex in forming and maintaining visual information, and use it as an example to highlight how noninvasive brain-stimulation techniques, particularly transcranial magnetic, direct current, and alternating current stimulation, can shed light on this topic because of their unique strengths in modulating brain activities.


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