Changes in hand function and motor cortex excitability in children following tDCS and CIMT therapy in children with unilateral cerebral palsy with different patterns of corticospinal organization

2017 ◽  
Vol 10 (4) ◽  
pp. e31
Author(s):  
Samuel Nemanich ◽  
Bernadette Gillick
2015 ◽  
Vol 58 (7) ◽  
pp. 735-742 ◽  
Author(s):  
Katrijn Klingels ◽  
Ellen Jaspers ◽  
Martin Staudt ◽  
Andrea Guzzetta ◽  
Lisa Mailleux ◽  
...  

2017 ◽  
Vol 31 (10-11) ◽  
pp. 965-976 ◽  
Author(s):  
Tonya L. Rich ◽  
Jeremiah S. Menk ◽  
Kyle D. Rudser ◽  
Timothy Feyma ◽  
Bernadette T. Gillick

Background. Neurorehabilitation interventions in children with unilateral cerebral palsy (UCP) target motor abilities in daily life yet deficits in hand skills persist. Limitations in the less-affected hand may affect overall bimanual hand skills. Objective. To compare hand function, by timed motor performance on the Jebsen-Taylor Test of Hand Function (JTTHF) and grip strength of children with UCP to children with typical development (CTD), aged 8 to 18 years old. Exploratory analyses compared hand function measures with regard to neurophysiological outcomes measured by transcranial magnetic stimulation and between group comparisons of hemispheric motor threshold. Methods. Baseline hand skills were evaluated in 47 children (21 UCP; 26 CTD). Single-pulse transcranial magnetic stimulation testing assessed corticospinal tract and motor threshold. Results. The mean difference of the less-affected hand of children with UCP to the dominant hand of CTD on the JTTHF was 21.4 seconds (95% CI = 9.32-33.46, P = .001). The mean difference in grip strength was −30.8 N (95% CI = −61.9 to 0.31, P = .052). Resting motor thresholds between groups were not significant, but age was significantly associated with resting motor threshold ( P < .001; P = .001). Children with UCP ipsilateral pattern of motor representation demonstrated greater mean differences between hands than children with contralateral pattern of motor representation ( P < .001). All results were adjusted for age and sex. Conclusions. The less-affected hand in children with UCP underperformed the dominant hand of CTD. Limitations were greater in children with UCP ipsilateral motor pattern. Rehabilitation in the less-affected hand may be warranted. Bilateral hand function in future studies may help identify the optimal rehabilitation and neuromodulatory intervention.


2018 ◽  
Vol 61 (5) ◽  
pp. 563-569 ◽  
Author(s):  
Leanne Sakzewski ◽  
Elisa Sicola ◽  
Cornelia H Verhage ◽  
Giuseppina Sgandurra ◽  
Ann‐Christin Eliasson

2010 ◽  
Vol 52 (4) ◽  
pp. 352-357 ◽  
Author(s):  
MARIE HOLMEFUR ◽  
LENA KRUMLINDE-SUNDHOLM ◽  
JAKOB BERGSTRÖM ◽  
ANN-CHRISTIN ELIASSON

2016 ◽  
Vol 30 (9) ◽  
pp. 834-844 ◽  
Author(s):  
Kathleen M. Friel ◽  
Hsing-Ching Kuo ◽  
Jason Fuller ◽  
Claudio L. Ferre ◽  
Marina Brandão ◽  
...  

2016 ◽  
Vol 20 (1) ◽  
pp. 114-124 ◽  
Author(s):  
Giovanni Baranello ◽  
Davide Rossi Sebastiano ◽  
Emanuela Pagliano ◽  
Elisa Visani ◽  
Claudia Ciano ◽  
...  

2012 ◽  
Vol 27 (1) ◽  
pp. 72-78 ◽  
Author(s):  
Marie Holmefur ◽  
Annika Kits ◽  
Jakob Bergström ◽  
Lena Krumlinde-Sundholm ◽  
Olof Flodmark ◽  
...  

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