Drug release from viscoelastic polymeric matrices - a stable and supraconvergent FDM

2021 ◽  
Vol 99 ◽  
pp. 257-269
Author(s):  
J.S. Borges ◽  
J.A. Ferreira ◽  
G. Romanazzi ◽  
E. Abreu
Keyword(s):  
Drug Release ◽  
Polymeric Matrices

scholarly journals New Biodegradable Poly(l-lactide)-Block-Poly(propylene adipate) Copolymer Microparticles for Long-Acting Injectables of Naltrexone Drug

Polymers ◽  
2020 ◽  
Vol 12 (4) ◽  
pp. 852 ◽  
Author(s):  
Stavroula Nanaki ◽  
Athina Viziridou ◽  
Alexandra Zamboulis ◽  
Margaritis Kostoglou ◽  
Georgios Z. Papageorgiou ◽  
...  
Keyword(s):  
Block Copolymers ◽  
Drug Release ◽  
Amorphous State ◽  
Copolymer Composition ◽  
Polymeric Matrices ◽  
Release Studies ◽  
Biodegradable Poly ◽  
Long Acting ◽  
Poly Propylene ◽  
Tga And Dsc

In the present study, novel block copolymers of poly(l-lactide)-block-poly(propylene adipate) (PLLA-b-PPAd) were synthesized in two ratios, 90/10 and 75/25 w/w and were further investigated as long-acting injectable (LAI) polymeric matrices in naltrexone base microparticle formulations. The synthesized polymers were characterized by 1H-NMR, 13C-NMR, FTIR, XRD, TGA and DSC. NMR and FTIR spectroscopies confirmed the successful synthesis of copolymers while DSC showed that these are block copolymers with well-defined and separated blocks. Microparticles were prepared by single emulsification method and were further characterized. Nanoparticles in the range of 0.4–4.5 μm were prepared as indicated by SEM, with copolymers giving the lowest particle size. By XRD and DSC it was found that naltrexone was present in the amorphous state in its microparticles. Dissolution study showed a drug release extending over seven days, indicating that these novel PLLA-b-PPAd copolymers could be promising matrices for naltrexone’s LAI formulations. It was evidenced that drug release depended on the copolymer composition. Model release studies showed that drug release is controlled by diffusion.

Effect of Montmorillonite on Drug Release from Polymeric Matrices

1989 ◽  
Vol 322 (11) ◽  
pp. 789-793 ◽  
Author(s):  
Flavio Forni ◽  
Valentina Iannuccelli ◽  
Gilberto Coppi ◽  
Maria Teresa Bernabei
Keyword(s):  
Drug Release ◽  
Polymeric Matrices

Repetitive on-demand drug release from polymeric matrices containing a macroscopic spherical iron core

2017 ◽  
Vol 28 (10) ◽  
Author(s):  
Stefan A. Rovers ◽  
Maartje F. Kemmere ◽  
Jos T. F. Keurentjes ◽  
Richard Hoogenboom
Keyword(s):  
Drug Release ◽  
Iron Core ◽  
Polymeric Matrices ◽  
On Demand

A multiscale mechanism of drug release from polymeric matrices: confirmation through a nonlinear theoretical model

2016 ◽  
Vol 18 (31) ◽  
pp. 21809-21816 ◽  
Author(s):  
E. S. Bacaita ◽  
M. Agop
Keyword(s):  
Theoretical Model ◽  
Drug Release ◽  
Release Kinetics ◽  
Release Mechanism ◽  
Polymeric Matrices

The overall release kinetics are obtained by composing “smaller kinetics” at scales appropriate for each phase of the release mechanism.

scholarly journals Effect of various surfactants and their concentration on controlled release of captopril from polymeric matrices

2008 ◽  
Vol 58 (2) ◽  
pp. 151-162 ◽  
Author(s):  
Ali Nokhodchi ◽  
Davoud Hassan-Zadeh ◽  
Farnaz Monajjem-Zadeh ◽  
Nita Taghi-Zadeh
Keyword(s):  
Controlled Release ◽  
Drug Release ◽  
Release Rate ◽  
Hydroxypropyl Methylcellulose ◽  
Water Soluble ◽  
Partial Replacement ◽  
Polymeric Matrices ◽  
Control Drug ◽  
Significant Difference ◽  
Release Data

Effect of various surfactants and their concentration on controlled release of captopril from polymeric matricesVarious methods are available to formulate water soluble drugs into sustained release dosage forms by retarding the dissolution rate. One of the methods used to control drug release and thereby prolong therapeutic activity is to use hydrophilic and lipophilic polymers. In this study, the effects of various polymers such as hydroxypropyl methylcellulose (HPMC), ethylcellulose (EC) and sodium carboxymethylcellulose (CMC) and surfactants (sodium lauryl sulphate, cetyltrimethylammonium bromide and Arlacel 60) on the release rate of captopril were investigated. The results showed that an increase in the amount of HPMC K15M resulted in reduction of the release rate of captopril from these matrices. When HPMC was partly replaced by NaCMC (the ratio of HPMC/NaCMC was 5:1), the release rate of the drug significantly decreased. However, there was no significant difference in release rate of captopril from matrices produced with ratios of 5:1 and 2:1 of HPMC/NaCMC. The presence of lactose in matrices containing HPMC and NaCMC increased the release rate of captopril. It was interesting to note that although partial replacement of HPMC by EC reduced the release rate of the drug (ratio of HPMC/EC 2:1), the release rate was increased when the ratio of HPMC/EC was reduced to 1:1. The effects of various surfactants on the release rate of captopril from HPMC/EC (1:1) matrices were also investigated. The results showed that the surfactants did not significantly change the release rate of the drug. Release data were examined kinetically and the ideal kinetic models were estimated for the drug release. The kinetic analysis of drug release data from various formulations showed that incorporation of surfactants in HPMC/EC matrices did not produce a zero-order release pattern.

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