Interrelationship between MYC gene numerical aberrations and protein expression in individuals from northern Brazil with early gastric adenocarcinoma

2008 ◽  
Vol 181 (1) ◽  
pp. 31-35 ◽  
Author(s):  
Láuren Cláudia Costa Raiol ◽  
Evely Cristina Figueira Silva ◽  
Diana Mendes da Fonseca ◽  
Mariana Ferreira Leal ◽  
Adriana Costa Guimarães ◽  
...  
Keyword(s):  
Protein Expression ◽  
Gastric Adenocarcinoma ◽  
Myc Gene ◽  
Numerical Aberrations ◽  
Northern Brazil

Interrelationships among chromosome aneuploidy, promoter hypermethylation, and protein expression of the CDKN2A gene in individuals from northern Brazil with gastric adenocarcinoma

2007 ◽  
Vol 179 (1) ◽  
pp. 45-51 ◽  
Author(s):  
Adriana Costa Guimarães ◽  
Eleonidas Moura Lima ◽  
André Salim Khayat ◽  
Mário Henrique Girão Faria ◽  
Silvia Helena Barem Rabenhorst ◽  
...  
Keyword(s):  
Protein Expression ◽  
Gastric Adenocarcinoma ◽  
Promoter Hypermethylation ◽  
Cdkn2a Gene ◽  
Chromosome Aneuploidy ◽  
Northern Brazil

scholarly journals Identification of Protein Expression Signatures Associated withHelicobacter pyloriInfection and Gastric Adenocarcinoma Using Recombinant Antibody Microarrays

2006 ◽  
Vol 5 (9) ◽  
pp. 1638-1646 ◽  
Author(s):  
Peter Ellmark ◽  
Johan Ingvarsson ◽  
Anders Carlsson ◽  
B. Samuel Lundin ◽  
Christer Wingren ◽  
...  
Keyword(s):  
Protein Expression ◽  
Gastric Adenocarcinoma ◽  
Recombinant Antibody ◽  
Antibody Microarrays

scholarly journals The Correlation Between Mutant p53 Protein Expression and Cell Atypia in Early Differentiated Gastric Adenocarcinoma

2021 ◽  
Vol Volume 13 ◽  
pp. 4129-4134
Author(s):  
Ming Tang ◽  
Peng-Jie Liu ◽  
Bing Yue ◽  
Xuan-Tao Yang ◽  
Guang-Yong Chen
Keyword(s):  
Protein Expression ◽  
Gastric Adenocarcinoma ◽  
P53 Protein ◽  
Mutant P53 ◽  
P53 Protein Expression ◽  
Cell Atypia

scholarly journals C-Myc Deregulation is Involved in Melphalan Resistance of Multiple Myeloma: Role of PDGF-BB

2006 ◽  
Vol 19 (1) ◽  
pp. 205873920601900 ◽  
Author(s):  
C. Greco ◽  
I. D'Agnano ◽  
G. Vitelli ◽  
R. Vona ◽  
M. Marino ◽  
...  
Keyword(s):  
Multiple Myeloma ◽  
Protein Expression ◽  
In Vitro Study ◽  
Angiogenic Factor ◽  
Cell Clones ◽  
Myc Gene ◽  
Β Receptor

Oncogenes are important regulators of cancer growth and progression and their action may be modulated by proteins of the growth factor family, such as angiogenic cytokines, known to be strongly involved in neoplastic evolution. Reciprocal interactions between oncogenes and angiogenic modulators may represent, in haematological neoplasms, including multiple myeloma (MM), a possible mechanism of drug resistance. The aim of this work is to investigate in vitro and in vivo whether or not c-myc deregulation is involved in the melphalan resistance elicited by myeloma patients and consequently to clarify the role of the angiogenic factor PDGF-BB in modulating c-myc protein expression. Fifty-one MM patients on chemotherapy with melphalan were analyzed for structural alterations of the c-myc gene, c-Myc protein expression, as well as for serum PDGF-BB release. For the in vitro study, two M14-derived established cell clones, differing for the c-Myc protein expression (c-Myc low -expressing or constitutively expressing clones) were used. Our results show that PDGF-BB is able to up-regulate Myc expression and reduce melphalan sensitivity of tumor cell clones, constitutively expressing c-myc gene product. In addition, down-regulation of c-Myc protein induces the expression of PDGF-β receptor molecules and reduces PDGF-BB release. In agreement with these results, in vivo data show that melphalan-resistant MM patients present overexpressed c-Myc protein and higher serum PDGF-β receptor levels compared to minor responding patients.

Polymorphisms of the TP53 codon 72 and WRN codon 1367 in individuals from Northern Brazil with gastric adenocarcinoma

2005 ◽  
Vol 5 (4) ◽  
pp. 161-168 ◽  
Author(s):  
A. S. Khayat ◽  
L. Lobo Gatti ◽  
E. Moura Lima ◽  
P. P. de Assumpção ◽  
F. J. Nascimento Motta ◽  
...  
Keyword(s):  
Gastric Adenocarcinoma ◽  
Codon 72 ◽  
Northern Brazil
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