HPV infection in Brazilian patients with esophageal squamous cell carcinoma: Interpopulational differences, lack of correlation with surrogate markers and clinicopathological parameters

Aims. We sought to determine the relationship between CADM1/TSLC1 expression and clinicopathological characteristics in patients with esophageal squamous cell carcinoma (ESCC) and the correlation with survival.Materials and Methods. Two hundred and ninety-three ESCC tissues and paired adjacent normal esophageal tissues were immunohistochemically assessed in this study. The association of CADM1/TSLC1 with clinicopathological parameters, as well as disease-free survival (DFS) and overall survival (OS), was determined based on the Kaplan-Meier method and Cox regression models.Results. CADM1/TSLC1 was detected in 236 (80.5%) tumor tissues and 19 (8.0%) paired adjacent normal esophageal tissues. Decreased CADM1/TSLC1 expression was correlated with more advanced histological grade. CADM1/TSLC1 negative tumors were more frequently observed in male cases than in female cases. DFS and OS in the CADM1/TSLC1 negative group were significantly shorter than those in the positive group, particularly in male patients with ESCC.Conclusion. Loss or reduction of CADM1/TSLC1 expression is associated with more advanced histological grade and predicts early recurrence and short survival duration. Thus, loss of CADM1/TSLC1 could be a prognostic factor that can be used to assess the risk of recurrence and survival.

Download Full-text

Genetic variability in LMP2 and LMP7 is associated with the risk of esophageal squamous cell carcinoma in the Kazakh population but is not associated with HPV infection

PLoS ONE ◽

10.1371/journal.pone.0186319 ◽

2017 ◽

Vol 12 (10) ◽

pp. e0186319 ◽

Cited By ~ 5

Author(s):

Lan Yang ◽

Yu Ji ◽

Ling Chen ◽

Mei Li ◽

Fei Wu ◽

...

Keyword(s):

Squamous Cell Carcinoma ◽

Genetic Variability ◽

Esophageal Squamous Cell Carcinoma ◽

Cell Carcinoma ◽

Squamous Cell ◽

Hpv Infection ◽

Kazakh Population

Download Full-text

HPV Infection and its Relationship with Expression of PIK3CA, PIK3CB in Esophageal Squamous Cells Carcinoma

10.21203/rs.3.rs-502500/v1 ◽

2021 ◽

Author(s):

Feifei Wen ◽

Yangyang Li ◽

Shuang He ◽

Xiaoyang Xu ◽

Ningjie Guo ◽

...

Keyword(s):

Squamous Cell Carcinoma ◽

Esophageal Squamous Cell Carcinoma ◽

Cell Carcinoma ◽

Squamous Cell ◽

Hpv Infection ◽

Tumor Location ◽

Esophageal Mucosa ◽

Squamous Cells ◽

Hpv Status

Abstract Background: Esophageal squamous cell carcinoma (ESCC) is a highly lethal cancer. Human papillomavirus (HPV) is currently considered as a potential risk factor for ESCC, but this assumption is still contradictory. P16INK4a (p16) staining can be used as an alternative marker of HPV oncogene activity. This study was to investigate the role of HPV in esophageal cancer and to compare the relationship between HPV status and PIK3CA, PIK3CB. Methods: Immunohistochemistry, Western blot, and RT-PCR analyses were performed to detect the expression of p16, PIK3CA, PIK3CB and p53 in 156 cases of esophageal squamous cell carcinoma. The patients were followed up by telephone or clinic. Results: The positive rates of p16, PIK3CA, PIK3CB and p53 in esophageal squamous cell carcinoma were significantly higher than those in normal esophageal mucosa. The overexpression of p16 was closely related to tumor location, TNM stage, differentiation and lymph node metastasis. In addition, the expression of p16 was positively correlated with the expression of PIK3CA, but not with the expression of PIK3CB and p53. Survival analysis showed that p16 was a good prognostic marker, while PIK3CA and p53 were poor prognostic markers. Conclusions: HPV infection is associated with ESCC. The imbalance of PI3K/Akt signaling pathway is closely related to HPV infection and prognosis. Detection of p16 and PIK3CA is of great significance in evaluating the prognosis and optimizing the treatment of esophageal squamous cell carcinoma.

Download Full-text

The Expression and Prognostic Value of FGF2, FGFR3, and FGFBP1 in Esophageal Squamous Cell Carcinoma

Analytical Cellular Pathology ◽

10.1155/2020/2872479 ◽

2020 ◽

Vol 2020 ◽

pp. 1-17

Author(s):

Wenjing Zhang ◽

Yaxing Zhou ◽

Chao Li ◽

Shanshan Xu ◽

Mengyan Li ◽

...

Keyword(s):

Squamous Cell Carcinoma ◽

Lymph Node ◽

Lymph Node Metastasis ◽

Esophageal Squamous Cell Carcinoma ◽

Cell Carcinoma ◽

Squamous Cell ◽

High Expression ◽

Clinicopathological Parameters ◽

Tumor Differentiation ◽

Node Metastasis

Background. Esophageal squamous cell carcinoma was treated by operation and chemoradiotherapy. However, the prognosis of most patients is poor after treatment, and most studies have shown that FGF2 and its receptor (FGFR) are involved in the development of various malignant tumors. FGF2 plays an important role in tumor progression and malignancy. In this study, the immunohistochemistry of FGF2, FGFR3, and FGFBP1 was used to further verify the expression of the three proteins in 172 patients with esophageal squamous cell carcinoma (ESCC) who had not received preoperative chemoradiotherapy and its effect on the prognosis of ESCC. Methods. (1) χ 2 test was used to analyze the relationship between proteins and clinicopathological parameters. Survival analysis was used to investigate the effect of three proteins on prognosis. (2) Paired sample t -test was used to analyze the mRNA expression of the three proteins in fresh ESCC tissues and adjacent normal tissues. Results. FGF2 was correlated with tumor size ( p = 0.026 ), gender ( p = 0.047 ), and lymph metastasis ( p = 0.007 ) in ESCC tissues. The high expression of FGFR3 was associated with tumor differentiation ( p = 0.043 and p < 0.05 ), lymph node metastasis ( p = 0.078 and p < 0.1 ), and race ( p = 0.033 and p < 0.05 ). The high expression of FGFBP1 was significantly associated with the degree of tumor differentiation ( p = 0.012 ), age ( p = 0.045 ), and lymph node metastasis ( p = 0.032 ) of ESCC patients. The expression of FGF2, FGFR3, and FGFBP1-mRNA in ESCC tissues was significantly higher than that in adjacent tissues ( p < 0.001 , p < 0.001 , and p = 0.001 ). Patients with high expression of FGF2, FGFBP1, and FGFR3 had poor prognosis. There was a weak positive correlation between FGF2 and FGFBP1, as well as FGFR. Conclusion. The FGF2-FGFR3 axis may promote the progression of esophageal squamous cell carcinoma. The FGF2-FGFR3 axis may be a new direction of targeted therapy for esophageal squamous cell carcinoma. FGF2 and FGFR3 may be used as prognostic markers of esophageal squamous cell carcinoma.

Download Full-text

Clinicopathological parameters predicting recurrence of pT1N0 esophageal squamous cell carcinoma

World Journal of Gastroenterology ◽

10.3748/wjg.v24.i45.5154 ◽

2018 ◽

Vol 24 (45) ◽

pp. 5154-5166 ◽

Cited By ~ 1

Author(s):

Li-Yan Xue ◽

Xiu-Min Qin ◽

Yong Liu ◽

Jun Liang ◽

Hua Lin ◽

...

Keyword(s):

Squamous Cell Carcinoma ◽

Esophageal Squamous Cell Carcinoma ◽

Cell Carcinoma ◽

Squamous Cell ◽

Clinicopathological Parameters

Download Full-text

The expression and prognostic value of SOX2, β-catenin and survivin in esophageal squamous cell carcinoma

Future Oncology ◽

10.2217/fon-2018-0884 ◽

2019 ◽

Vol 15 (36) ◽

pp. 4181-4195

Author(s):

Ya-Xing Zhou ◽

Qian Liu ◽

Hui Wang ◽

Fend Ding ◽

Yu-Qing Ma

Keyword(s):

Squamous Cell Carcinoma ◽

Lymph Node ◽

Lymph Node Metastasis ◽

Esophageal Squamous Cell Carcinoma ◽

Cell Carcinoma ◽

Squamous Cell ◽

Clinicopathological Parameters ◽

Depth Of Invasion ◽

Node Metastasis ◽

Short Time

Aim: We mainly explored the effect of SOX2, β-catenin and survivin on prognosis in esophageal squamous cell carcinoma. Materials & methods: Immunohistochemistry was used to examine the expression of SOX2, β-catenin and survivin. χ2 test was used to analyze the relationship between proteins and clinicopathological parameters. Survival analysis was used to investigate the effect of three proteins on prognosis. Results: SOX2 was related to lymph node metastasis (p = 0.004) and vascular invasion (p = 0.041). β-catenin was associated with depth of invasion (p = 0.014), lymph node metastasis (p = 0.032) and postoperative chemoradiotherapy (p < 0.001). Survivin was related to gender (p = 0.022) and nerve invasion (p = 0.014). There was a positive correlation between SOX2 and β-catenin. Patients with SOX2 and β-catenin overexpression had poor prognosis. Survivin-positive patients who received postoperative chemoradiotherapy had a short time. Conclusion: SOX2, β-catenin and survivin can be used as prognostic markers of esophageal squamous cell carcinoma.

Download Full-text