Microwave assisted synthesis of acrylamide grafted locust bean gum and its application in drug delivery

Hydrodynamically Balanced systems have wide development as they have achieved the parameters of modern drug delivery system, it is a type of system which owes very tremendous and curative benefits for the delivery of oral controlled release dosage forms and have wide properties in many aspects such as its main role is to maintain the effective concentration in the system for longer period of time. To reduce the gastric mucosal irritation due to the presence of synthetic polymers, being a natural polymer incorporation of Plantago ovate (Psyllium Husk) could ease out the mucosal irritation in the gastric region. Due to its properties such as a rate-controlling polymer possessing a very good quality of swelling and good gelling nature, and also incorporated as a matrix-forming agent basically in the modified release formulation. Locust bean gum can be used as sustained-release carriers and release modifiers for the delivery of drugs. It is a neutral plant galactomannan extracted from the seeds (kernels) of the carob tree Ceratonia siliqua L fabaceae. Nowadays it is focussing polymer and a lot of researchers are focussing on exploring the potential in topical drug delivery, colonic drug delivery, oral sustained drug delivery, ocular drug delivery, buccal drug delivery.

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Rapid microwave-assisted synthesis of gold loaded hydroxyapatite collagen nano-bio materials for drug delivery and tissue engineering application

Ceramics International ◽

10.1016/j.ceramint.2018.10.016 ◽

2019 ◽

Vol 45 (3) ◽

pp. 2977-2988 ◽

Cited By ~ 16

Author(s):

Sudip Mondal ◽

Giang Hoang ◽

Panchanathan Manivasagan ◽

Madhappan Santha Moorthy ◽

Thi Tuong Vy Phan ◽

...

Keyword(s):

Drug Delivery ◽

Tissue Engineering ◽

Engineering Application ◽

Microwave Assisted Synthesis ◽

Tissue Engineering Application ◽

Microwave Assisted

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Sodium alginate/locust bean gum-g-methacrylic acid IPN hydrogels for “simvastatin” drug delivery

Journal of Dispersion Science and Technology ◽

10.1080/01932691.2019.1677247 ◽

2019 ◽

Vol 41 (14) ◽

pp. 2192-2202 ◽

Cited By ~ 3

Author(s):

Madhavi Chintha ◽

Sreekanth Reddy Obireddy ◽

Parandhama Areti ◽

Subha Marata Chinna Subbarao ◽

Chowdoji Rao Kashayi ◽

...

Keyword(s):

Drug Delivery ◽

Sodium Alginate ◽

Methacrylic Acid ◽

Locust Bean Gum ◽

Locust Bean

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Application of Design of Experiment for Floating Drug Delivery of Tapentadol Hydrochloride

Computational and Mathematical Methods in Medicine ◽

10.1155/2013/625729 ◽

2013 ◽

Vol 2013 ◽

pp. 1-7 ◽

Cited By ~ 6

Author(s):

Swati C. Jagdale ◽

Somnath Patil ◽

Bhanudas S. Kuchekar

Keyword(s):

Drug Delivery ◽

Sodium Bicarbonate ◽

Design Of Experiment ◽

Xanthan Gum ◽

Locust Bean Gum ◽

Sustained Drug Release ◽

Clinical Pain ◽

Floating Drug Delivery ◽

Locust Bean ◽

Full Factorial

The aim of the present study was to apply design of experiment (DOE) to optimize floating drug delivery of tapentadol hydrochloride. Tapentadol hydrochloride is a synthetic opioid used as a centrally acting analgesic and effective in both experimental and clinical pain. The half-life of the drug is about 4 hours and oral dose is 50 to 250 mg twice a day. For optimization 32full factorial design was employed for formulation of tapentadol hydrochloride tablets. Sodium bicarbonate was incorporated as a gas-generating agent. Combination of polymers Xanthan gum and Locust bean gum was used to achieve controlled release effect. The concentration of polymers was considered as the independent variables and dependent variables were floating lag time and swelling index of the tablets. From the factorial batches, it was observed that formulation containing combination of 20% sodium bicarbonate and 10% citric acid shows optimum floating ability whereas the formulation containing 20% Xanthan gum and 28% Locust bean gum shows optimum sustained drug release pattern with adequate floating.

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