Assessment of Cardiac Fiber Orientation, Function, and Morphology in a Swine Model of Dilated Cardiomyopathy Using MRI

2010 ◽  
Vol 16 (8) ◽  
pp. S26
Author(s):  
Michael D. Eggen ◽  
Michael G. Bateman ◽  
Christopher D. Rolfes ◽  
Stephen A. Howard ◽  
Cory M. Swingen ◽  
...  
1997 ◽  
Vol 30 (10) ◽  
pp. 1041-1049 ◽  
Author(s):  
J. Rijeken ◽  
P.H.M. Bovendeerd ◽  
A.J.G. Schoofs ◽  
D.H. van Campen ◽  
T. Arts

2006 ◽  
Vol 324-325 ◽  
pp. 415-418
Author(s):  
Jin Woo Kim ◽  
Dong Gi Lee

While mold fiber reinforced composite material to problem of occasion that high temperature compression molding, flow length in mold is overlong or when flow meets with resistance in side of mold, fiber orientation happens and big change occurs in strength or quality. Thus, in compression molding that use fiber reinforced composite material, orientation state of fiber in moldings is the most basic element that quotes various properties of matter values. Therefore, to clear orientation state of fiber establishing measurement of fiber orientation angle distribution is very important while give correction of molding condition decision, mechanical quality of moldings and guide about material design. In the study, the fiber orientation distribution of simulation figure plotted by PC is measured using image processing in order to examine the accuracy of intersection counting method. The fiber orientation function measured by intersection counting method using image processing is compared with the calculated fiber orientation function. The results show that the measured value of fiber orientation function using intersection counting method is lower than the calculated value, because the number of intersection between the scanning line and the fiber with smaller fiber aspect ratio is counted less than with larger fiber aspect ratio.


2020 ◽  
Vol 12 (573) ◽  
pp. eabb3336 ◽  
Author(s):  
Kenta Hirai ◽  
Daiki Ousaka ◽  
Yosuke Fukushima ◽  
Maiko Kondo ◽  
Takahiro Eitoku ◽  
...  

Although cardiosphere-derived cells (CDCs) improve cardiac function and outcomes in patients with single ventricle physiology, little is known about their safety and therapeutic benefit in children with dilated cardiomyopathy (DCM). We aimed to determine the safety and efficacy of CDCs in a porcine model of DCM and translate the preclinical results into this patient population. A swine model of DCM using intracoronary injection of microspheres created cardiac dysfunction. Forty pigs were randomized as preclinical validation of the delivery method and CDC doses, and CDC-secreted exosome (CDCex)–mediated cardiac repair was analyzed. A phase 1 safety cohort enrolled five pediatric patients with DCM and reduced ejection fraction to receive CDC infusion. The primary endpoint was to assess safety, and the secondary outcome measure was change in cardiac function. Improved cardiac function and reduced myocardial fibrosis were noted in animals treated with CDCs compared with placebo. These functional benefits were mediated via CDCex that were highly enriched with proangiogenic and cardioprotective microRNAs (miRNAs), whereas isolated CDCex did not recapitulate these reparative effects. One-year follow-up of safety lead-in stage was completed with favorable profile and preliminary efficacy outcomes. Increased CDCex-derived miR-146a-5p expression was associated with the reduction in myocardial fibrosis via suppression of proinflammatory cytokines and transcripts. Collectively, intracoronary CDC administration is safe and improves cardiac function through CDCex in a porcine model of DCM. The safety lead-in results in patients provide a translational framework for further studies of randomized trials and CDCex-derived miRNAs as potential paracrine mediators underlying this therapeutic strategy.


2017 ◽  
Vol 7 (1) ◽  
Author(s):  
Clement Papadacci ◽  
Victor Finel ◽  
Jean Provost ◽  
Olivier Villemain ◽  
Patrick Bruneval ◽  
...  

2004 ◽  
Vol 1015 (1) ◽  
pp. 190-201 ◽  
Author(s):  
TAMMO DELHAAS ◽  
WIM DECALUWE ◽  
MIRJAM RUBBENS ◽  
ROY KERCKHOFFS ◽  
THEO ARTS

2014 ◽  
Vol 44 (S1) ◽  
pp. 116-116 ◽  
Author(s):  
F. Crispi ◽  
A. Gonzalez-Tendero ◽  
C. Zhang ◽  
V. Balicevic ◽  
R. Cardenas ◽  
...  

2008 ◽  
Vol 13 (3) ◽  
pp. 030505 ◽  
Author(s):  
Christine P. Fleming ◽  
Crystal M. Ripplinger ◽  
Bryan Webb ◽  
Igor R. Efimov ◽  
Andrew M. Rollins

Author(s):  
Karim Lekadir ◽  
Babak Ghafaryasl ◽  
Emma Muñoz-Moreno ◽  
Constantine Butakoff ◽  
Corné Hoogendoorn ◽  
...  

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