Fluorinated cyclitols as useful biological probes of phosphatidylinositol metabolism

2004 ◽  
Vol 339 (9) ◽  
pp. 1585-1595 ◽  
Author(s):  
David J.A. Schedler ◽  
David C. Baker
Keyword(s):  
Biological Probes ◽  
Phosphatidylinositol Metabolism

Fluorinated Analogues ofmyo-Inositols as Biological Probes of Phosphatidylinositol Metabolism

1988 ◽  
pp. 43-58 ◽  
Author(s):  
James D. Moyer ◽  
Ofer Reizes ◽  
Nancy Malinowski ◽  
Cong Jiang ◽  
David C. Baker
Keyword(s):  
Biological Probes ◽  
Phosphatidylinositol Metabolism

Recent advances on the synthesis of the antidepressant Paroxetine

2020 ◽  
Vol 27 ◽  
Author(s):  
Joana Santos ◽  
M. Fernanda Proença ◽  
Ana Joao Rodrigues ◽  
Patricia Patrício ◽  
H. Sofia Domingues
Keyword(s):  
Total Synthesis ◽  
Neurological Disorders ◽  
Serotonin Reuptake ◽  
Potent Inhibitor ◽  
Starting Material ◽  
Substitution Pattern ◽  
Biological Probes ◽  
Recent Advances ◽  
Treatment Of Depression ◽  
Made In

: Paroxetine is a potent inhibitor of serotonin reuptake and is widely prescribed for the treatment of depression and other neurological disorders. The synthesis of paroxetine and the possibility to prepare derivatives with a specific substitution pattern that may allow their use as biological probes, is an attractive topic especially for medicinal chemists engaged in neurosciences research. Considering the extensive work that was developed in the last decade on the total synthesis of paroxetine, this review summarizes the most important contributions in this field, organized according to the reagent that was used as starting material. Most of the methods allowed to prepare paroxetine in 4-9 steps with an overall yield of 9-66%. Despite the progress made in this area, there is still room for improvement, searching for new eco-friendly and sustainable synthetic alternatives.

Phosphatidylinositol metabolism in cells transformed by polyomavirus middle T antigen.

1990 ◽  
Vol 64 (8) ◽  
pp. 3895-3904 ◽  
Author(s):  
E T Ulug ◽  
P T Hawkins ◽  
M R Hanley ◽  
S A Courtneidge
Keyword(s):  
T Antigen ◽  
Phosphatidylinositol Metabolism ◽  
Polyomavirus Middle T Antigen ◽  
Middle T Antigen ◽  
In Cells

scholarly journals Overriding Phthalate Decomposition When Exploring Mycophenolic Acid Intermediates as Selenium-Based ROS Biological Probes

ACS Omega ◽  
2018 ◽  
Vol 3 (10) ◽  
pp. 13474-13483 ◽  
Author(s):  
Mahesh B. Halle ◽  
Tesla Yudhistira ◽  
Kyung Jin Lee ◽  
Jae Hyuck Choi ◽  
Youngsam Kim ◽  
...  
Keyword(s):  
Mycophenolic Acid ◽  
Biological Probes

Water-dispersible near-infrared Ag2S nanoclusters with tunable fluorescence for bioimaging application

RSC Advances ◽  
2015 ◽  
Vol 5 (99) ◽  
pp. 80929-80932 ◽  
Author(s):  
Xiaofang Jia ◽  
Dan Li ◽  
Jing Li ◽  
Erkang Wang
Keyword(s):  
Aqueous Phase ◽  
Microwave Synthesis ◽  
Near Infrared ◽  
Cellular Imaging ◽  
Water Dispersible ◽  
Biological Probes ◽  
Tunable Emission

Water-dispersed ultrasmall Ag2S nanoclusters (NCs) are prepared directly in aqueous phase via a facile microwave synthesis. The resultant Ag2S NCs with tunable emission from visible to NIR region are promising biological probes for cellular imaging.

Stimulation of phosphatidylinositol metabolism in atrial and ventricular myocytes

Life Sciences ◽  
1986 ◽  
Vol 39 (23) ◽  
pp. 2215-2220 ◽  
Author(s):  
Edward Leung ◽  
Colin I. Johnston ◽  
Elizabeth A. Woodcock
Keyword(s):  
Ventricular Myocytes ◽  
Phosphatidylinositol Metabolism ◽  
Stimulation Of
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