Neutrophil gelatinase associated lipocalin as an early marker for diabetic nephropathy in Qatari population

2019 ◽  
Vol 493 ◽  
pp. S272-S273
Author(s):  
E. Sharif ◽  
S. Chowdhury ◽  
H. Ech-Cherif
2021 ◽  
Vol 84 (1) ◽  
pp. 2226-2230
Author(s):  
Hoda Gouda Bakr ◽  
Khaled Ahmed Elbana ◽  
Abeer Abd Alla Fekry ◽  
Mahmoud Samir Elkot

2015 ◽  
Vol 2015 ◽  
pp. 1-14 ◽  
Author(s):  
Luca Musante ◽  
Dorota Tataruch ◽  
Dongfeng Gu ◽  
Xinyu Liu ◽  
Carol Forsblom ◽  
...  

Diabetic nephropathy (DN) is one of the major complications of diabetes mellitus (DM), leads to chronic kidney disease (CKD), and, ultimately, is the main cause for end-stage kidney disease (ESKD). Beyond urinary albumin, no reliable biomarkers are available for accurate early diagnostics. Urinary extracellular vesicles (UEVs) have recently emerged as an interesting source of diagnostic and prognostic disease biomarkers. Here we used a protease and respective protease inhibitor array to profile urines of type 1 diabetes patients at different stages of kidney involvement. Urine samples were divided into groups based on the level of albuminuria and UEVs isolated by hydrostatic dialysis and screened for relative changes of 34 different proteases and 32 protease inhibitors, respectively. Interestingly, myeloblastin and its natural inhibitor elafin showed an increase in the normo- and microalbuminuric groups. Similarly, a characteristic pattern was observed in the array of protease inhibitors, with a marked increase of cystatin B, natural inhibitor of cathepsins L, H, and B as well as of neutrophil gelatinase-associated Lipocalin (NGAL) in the normoalbuminuric group. This study shows for the first time the distinctive alterations in comprehensive protease profiles of UEVs in diabetic nephropathy and uncovers intriguing mechanistic, prognostic, and diagnostic features of kidney damage in diabetes.


2018 ◽  
Vol 38 (6) ◽  
pp. 524-529 ◽  
Author(s):  
So Young Kim ◽  
Tae-Dong Jeong ◽  
Woochang Lee ◽  
Sail Chun ◽  
Sung Sunwoo ◽  
...  

2016 ◽  
Vol 36 (2) ◽  
pp. 121-125 ◽  
Author(s):  
Chenna Chandrashekar ◽  
Akila Venkatkrishnan

Introduction: Acute Kidney Injury (AKI) is a common devastating problem in the NICU. Since the kidney is the second most affected organ in asphyxiated neonates (after the brain), a marker to determine kidney injury becomes important. Serum Neutrophil Gelatinase Associated Lipocalin (NGAL) determines acute kidney injury even before Blood Urea Nitrogen (BUN) or serum creatinine values rise. The aim of this study was to determine the clinical utility of NGAL as an early marker of acute kidney injury in asphyxiated neonates.Materials and Methods: This was a cohort study performed at a Level III NICU at JSS Hospital, Mysore, Karnataka, India over a period of two years. The study was conducted on30 term asphyxiated neonates and 30 term control neonates. Serum NGAL was measured within 6 hours after birth in an asphyxiated neonate using fluorescence immunoassay.Results: A highly significant increase in serum NGAL in cases group with a median of 323ng/ml as compared to control group with median of 64ng/ml was observed. Of the 30 asphyxiated neonates, 23 were positive for NGAL, and of these 3 had AKI.A cutoff value of 155 ng/ml for Serum NGAL could detect AKI in asphyxiated neonates with a sensitivity of 75% and a specificity of 23%.Conclusion: NGAL is raised in Asphyxiated neonates both with and without kidney injury. Therefore, it is not a specific marker for acute kidney injury in asphyxiated neonates.  J Nepal Paediatr Soc 2016;36(2):121-125.


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