H. pylori-encoded CagA disrupts tight junctions and induces invasiveness of AGS gastric carcinoma cells via Cdx2-dependent targeting of Claudin-2

2013 ◽  
Vol 286 (1-2) ◽  
pp. 22-30 ◽  
Author(s):  
Xin Song ◽  
Hui-Xin Chen ◽  
Xiao-Yan Wang ◽  
Xi-Yun Deng ◽  
Yin-Xue Xi ◽  
...  
Keyword(s):  
Gastric Carcinoma ◽  
Tight Junctions ◽  
Carcinoma Cells ◽  
H Pylori

Vitamin C affects G0/G1 cell cycle and autophagy by downregulating of cyclin D1 in gastric carcinoma cells

2021 ◽  
Vol 85 (3) ◽  
pp. 553-561
Author(s):  
Chenxia Ren ◽  
Cuiling Wu ◽  
Changqing Yang ◽  
Changhong Lian
Keyword(s):  
Cell Cycle ◽  
Gastric Carcinoma ◽  
Vitamin C ◽  
Cyclin D1 ◽  
Bioinformatics Analysis ◽  
Carcinoma Cells ◽  
Cell Cycle Pathway ◽  
Differential Gene ◽  
Regulation Of Cell Cycle ◽  
Amp Activated Protein Kinase

ABSTRACT Vitamin C has re-emerged as a promising anticancer agent. This study attempts to analyze the differential gene expression of profiles GSE11919 to look for some clues, and the most significant cell cycle pathway caused by vitamin C was identified by integrated bioinformatics analysis. Inspired by this, we investigated the effect of vitamin C treatment on gastric carcinoma cells by detection of cell cycle, apoptosis, and autophagy. Vitamin C significantly elevated the percentage of cells at G0/G1 phase, whereas the percentage of S phase cells was decreased. Meanwhile, vitamin C treatment resulted in downregulation of cell cycle-related protein Cyclin D1. We deduced that the downregulation of Cyclin D1 by vitamin C accompanied by significantly increased 5′AMP-activated protein kinase and induced autophagy in MKN45 cells. These results suggest that vitamin C has the antiproliferation effect on gastric carcinoma cells via the regulation of cell cycle and autophagy by Cyclin D1.

CD40 signaling activated by agonistic anti-CD40 monoclonal antibody 5C11 has different effects on biological behavior of gastric carcinoma cells

2010 ◽  
Vol 131 (2) ◽  
pp. 120-125 ◽  
Author(s):  
Rui Li ◽  
Wei-chang Chen ◽  
Wei-peng Wang ◽  
Wen-yan Tian ◽  
Xue-guang Zhang
Keyword(s):  
Monoclonal Antibody ◽  
Gastric Carcinoma ◽  
Carcinoma Cells ◽  
Biological Behavior

Screening for gastric carcinoma using H. pylori serology

1998 ◽  
Vol 114 ◽  
pp. A593
Author(s):  
S Everett ◽  
J Davies ◽  
M Wilcox ◽  
H Sue-Ling ◽  
D Johnston ◽  
...  
Keyword(s):  
Gastric Carcinoma ◽  
H Pylori

Dynamic characterization of drug resistance and heterogeneity of the gastric cancer cell BGC823 using single-cell Raman spectroscopy

The Analyst ◽  
2018 ◽  
Vol 143 (1) ◽  
pp. 164-174 ◽  
Author(s):  
Yong Zhang ◽  
Ludi Jin ◽  
Jingjing Xu ◽  
Yuezhou Yu ◽  
Lin Shen ◽  
...  
Keyword(s):  
Gastric Cancer ◽  
Raman Spectroscopy ◽  
Drug Resistance ◽  
Gastric Carcinoma ◽  
Single Cell ◽  
Gastric Cancer Cell ◽  
Carcinoma Cells ◽  
Dynamic Characterization ◽  
Human Gastric Carcinoma Cells

Drug resistance and heterogeneous characteristics of human gastric carcinoma cells (BGC823) under the treatment of paclitaxel (PTX) were investigated using single-cell Raman spectroscopy (RS).

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