Protein phosphatase PP1 negatively regulates the Toll-like receptor- and RIG-I-like receptor-triggered production of type I interferon by inhibiting IRF3 phosphorylation at serines 396 and 385 in macrophage

2014 ◽  
Vol 26 (12) ◽  
pp. 2930-2939 ◽  
Author(s):  
Meidi Gu ◽  
Ting Zhang ◽  
Wenlong lin ◽  
Zhiyong Liu ◽  
Rongrong Lai ◽  
...  
Keyword(s):  
Protein Phosphatase ◽  
Type I Interferon ◽  
Type I ◽  
Toll Like Receptor

scholarly journals Cancer Vaccine Immunotherapy with RNA-Loaded Liposomes

2018 ◽  
Vol 19 (10) ◽  
pp. 2890 ◽  
Author(s):  
Elias Sayour ◽  
Hector Mendez-Gomez ◽  
Duane Mitchell
Keyword(s):  
Immune Suppression ◽  
Cancer Vaccines ◽  
Type I Interferon ◽  
Type I ◽  
Toll Like Receptor ◽  
Adaptive Responses ◽  
Receptor Stimulation ◽  
Delivery Vehicles ◽  
Therapeutic Settings

Cancer vaccines may be harnessed to incite immunity against poorly immunogenic tumors, however they have failed in therapeutic settings. Poor antigenicity coupled with systemic and intratumoral immune suppression have been significant drawbacks. RNA encoding for tumor associated or specific epitopes can serve as a more immunogenic and expeditious trigger of anti-tumor immunity. RNA stimulates innate immunity through toll like receptor stimulation producing type I interferon, and it mediates potent adaptive responses. Since RNA is inherently unstable, delivery systems have been developed to protect and deliver it to intended targets in vivo. In this review, we discuss liposomes as RNA delivery vehicles and their role as cancer vaccines.

scholarly journals Enhanced expression of type I interferon and toll-like receptor-3 in primary biliary cirrhosis

2005 ◽  
Vol 85 (7) ◽  
pp. 908-920 ◽  
Author(s):  
Yasushi Takii ◽  
Minoru Nakamura ◽  
Masahiro Ito ◽  
Terufumi Yokoyama ◽  
Atsumasa Komori ◽  
...  
Keyword(s):  
Primary Biliary Cirrhosis ◽  
Type I Interferon ◽  
Type I ◽  
Biliary Cirrhosis ◽  
Toll Like Receptor ◽  
Enhanced Expression

scholarly journals Regulation of TLR7/9 responses in plasmacytoid dendritic cells by BST2 and ILT7 receptor interaction

2009 ◽  
Vol 206 (7) ◽  
pp. 1603-1614 ◽  
Author(s):  
Wei Cao ◽  
Laura Bover ◽  
Minkwon Cho ◽  
Xiaoxia Wen ◽  
Shino Hanabuchi ◽  
...  
Keyword(s):  
Dendritic Cells ◽  
Proinflammatory Cytokines ◽  
Stromal Cell ◽  
Bone Marrow Stromal Cell ◽  
Type I Interferon ◽  
Plasmacytoid Dendritic Cells ◽  
Orphan Receptor ◽  
Receptor Interaction ◽  
Type I ◽  
Toll Like Receptor

Plasmacytoid dendritic cells (pDCs) produce copious type I interferon (IFN) upon sensing nucleic acids through Toll-like receptor (TLR) 7 and TLR9. Uncontrolled pDC activation and IFN production are implicated in lymphopenia and autoimmune diseases; therefore, a mechanism controlling pDC IFN production is essential. Human pDCs specifically express an orphan receptor, immunoglobulin-like transcript 7 (ILT7). Here, we discovered an ILT7 ligand expressed by human cell lines and identified it as bone marrow stromal cell antigen 2 (BST2; CD317). BST2 directly binds to purified ILT7 protein, initiates signaling via the ILT7–FcεRIγ complex, and strongly inhibits production of IFN and proinflammatory cytokines by pDCs. Readily induced by IFN and other proinflammatory cytokines, BST2 may modulate the human pDC’s IFN responses through ILT7 in a negative feedback fashion.

scholarly journals Toll-like receptor 3 upregulation by type I interferon in healthy and scleroderma dermal fibroblasts

2011 ◽  
Vol 13 (1) ◽  
pp. R3 ◽  
Author(s):  
Sandeep K Agarwal ◽  
Minghua Wu ◽  
Christopher K Livingston ◽  
Donald H Parks ◽  
Maureen D Mayes ◽  
...  
Keyword(s):  
Type I Interferon ◽  
Dermal Fibroblasts ◽  
Type I ◽  
Toll Like Receptor
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