scholarly journals VEGF-A/Notch-Induced Podosomes Proteolyse Basement Membrane Collagen-IV during Retinal Sprouting Angiogenesis

Cell Reports ◽  
2016 ◽  
Vol 17 (2) ◽  
pp. 484-500 ◽  
Author(s):  
Pirjo Spuul ◽  
Thomas Daubon ◽  
Bettina Pitter ◽  
Florian Alonso ◽  
Isabelle Fremaux ◽  
...  
Keyword(s):  
Basement Membrane ◽  
Collagen Iv ◽  
Sprouting Angiogenesis ◽  
Basement Membrane Collagen ◽  
Membrane Collagen

scholarly journals Macrophages adhere to glucose-modified basement membrane collagen IV via their scavenger receptors.

1994 ◽  
Vol 269 (14) ◽  
pp. 10197-10200 ◽  
Author(s):  
J. el Khoury ◽  
C.A. Thomas ◽  
J.D. Loike ◽  
S.E. Hickman ◽  
L. Cao ◽  
...  
Keyword(s):  
Basement Membrane ◽  
Collagen Iv ◽  
Scavenger Receptors ◽  
Basement Membrane Collagen ◽  
Membrane Collagen

scholarly journals Characterization of Recombinant Human Prolyl 3-Hydroxylase Isoenzyme 2, an Enzyme Modifying the Basement Membrane Collagen IV

2008 ◽  
Vol 283 (28) ◽  
pp. 19432-19439 ◽  
Author(s):  
Päivi Tiainen ◽  
Annika Pasanen ◽  
Raija Sormunen ◽  
Johanna Myllyharju
Keyword(s):  
Basement Membrane ◽  
Collagen Iv ◽  
Basement Membrane Collagen ◽  
Membrane Collagen

scholarly journals Basement membrane collagen in the kidney: Regional localization of novel chains related to collagen IV

1989 ◽  
Vol 35 (5) ◽  
pp. 1195-1202 ◽  
Author(s):  
Ralph J. Butkowski ◽  
Jörgen Wieslander ◽  
Mary Kleppel ◽  
Alfred F. Michael ◽  
Alfred J. Fish
Keyword(s):  
Basement Membrane ◽  
Collagen Iv ◽  
Regional Localization ◽  
Basement Membrane Collagen ◽  
Membrane Collagen

Site-specific cleavage of basement membrane collagen IV during Drosophila metamorphosis

Development ◽  
1993 ◽  
Vol 117 (3) ◽  
pp. 1061-1069 ◽  
Author(s):  
L.I. Fessler ◽  
M.L. Condic ◽  
R.E. Nelson ◽  
J.H. Fessler ◽  
J.W. Fristrom
Keyword(s):  
Drosophila Melanogaster ◽  
Amino Acid ◽  
Basement Membrane ◽  
Collagen Iv ◽  
Basement Membranes ◽  
The Other ◽  
Supramolecular Network ◽  
Site Specific ◽  
Basement Membrane Collagen ◽  
Membrane Collagen

Breakdown of basement membranes is an important step in the controlled rearrangement of cells during metamorphosis, cell migration, and metastatic spread of tumor cells. One of our two laboratories found a unique collagenous peptide that only appears during metamorphosis of Drosophila melanogaster. The other laboratory previously reported that during 20-hydroxyecdysone-induced eversion of Drosophila imaginal discs a glycoprotein named gp125 arises (Birr et al., 1990). We show that these two peptides are identical and that they are formed from basement membrane collagen IV. Cleavage occurs at an imperfection of this homotrimeric collagen helix between residues 755/756 in the sequence CALDE/IKMPAK. The peptide is the carboxyl fragment, 100,647 M(r), as derived from the amino acid sequence of the collagen alpha 1(IV) chain. The corresponding amino fragment was also recovered from a disulfide-linked aggregate. This specific cleavage supports the concept of highly targeted, controlled breakdown of basement membranes during metamorphosis. Furthermore, these cuts occur at strategic sites of the predicted supramolecular network of collagen IV molecules of Drosophila basement membranes.

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