A novel strategy for prediction of human plasma protein binding using machine learning techniques

Chemometrics and Intelligent Laboratory Systems ◽

10.1016/j.chemolab.2020.103962 ◽

2020 ◽

Vol 199 ◽

pp. 103962

Author(s):

Yawen Yuan ◽

Shuo Chang ◽

Zheng Zhang ◽

Zhigang Li ◽

Size Li ◽

...

Keyword(s):

Machine Learning ◽

Protein Binding ◽

Human Plasma ◽

Plasma Protein Binding ◽

Plasma Protein ◽

Machine Learning Techniques ◽

Human Plasma Protein ◽

Learning Techniques ◽

Download Full-text

Informing the Human Plasma Protein Binding of Environmental Chemicals by Machine Learning in the Pharmaceutical Space: Applicability Domain and Limits of Predictability

Journal of Chemical Information and Modeling ◽

10.1021/acs.jcim.6b00291 ◽

2016 ◽

Vol 56 (11) ◽

pp. 2243-2252 ◽

Author(s):

Brandall L. Ingle ◽

Brandon C. Veber ◽

John W. Nichols ◽

Rogelio Tornero-Velez

Keyword(s):

Machine Learning ◽

Protein Binding ◽

Human Plasma ◽

Plasma Protein Binding ◽

Plasma Protein ◽

Environmental Chemicals ◽

Applicability Domain ◽

Human Plasma Protein

Download Full-text

Predicting human plasma protein binding of drugs using plasma protein interaction QSAR analysis (PPI-QSAR)

Biopharmaceutics & Drug Disposition ◽

10.1002/bdd.762 ◽

2011 ◽

Vol 32 (6) ◽

pp. 333-342 ◽

Author(s):

Haiyan Li ◽

Zhuxi Chen ◽

Xuejun Xu ◽

Xiaofan Sui ◽

Tao Guo ◽

...

Keyword(s):

Protein Binding ◽

Human Plasma ◽

Plasma Protein Binding ◽

Plasma Protein ◽

Protein Interaction ◽

Qsar Analysis ◽

Human Plasma Protein ◽

Protein Binding Of Drugs

Download Full-text

Simultaneous determination of human plasma protein binding of bioactive flavonoids in Polygonum orientale by equilibrium dialysis combined with UPLC–MS/MS

Journal of Pharmaceutical Analysis ◽

10.1016/j.jpha.2013.04.001 ◽

2013 ◽

Vol 3 (5) ◽

pp. 376-381 ◽

Author(s):

Yong Huang ◽

Hui Chen ◽

Feng He ◽

Zhi-Rong Zhang ◽

Lin Zheng ◽

...

Keyword(s):

Protein Binding ◽

Simultaneous Determination ◽

Human Plasma ◽

Plasma Protein Binding ◽

Plasma Protein ◽

Equilibrium Dialysis ◽

Human Plasma Protein

Download Full-text

Prediction models of human plasma protein binding rate and oral bioavailability derived by using GA–CG–SVM method

Journal of Pharmaceutical and Biomedical Analysis ◽

10.1016/j.jpba.2008.03.023 ◽

2008 ◽

Vol 47 (4-5) ◽

pp. 677-682 ◽

Author(s):

Chang-Ying Ma ◽

Sheng-Yong Yang ◽

Hui Zhang ◽

Ming-Li Xiang ◽

Qi Huang ◽

...

Keyword(s):

Protein Binding ◽

Human Plasma ◽

Plasma Protein Binding ◽

Plasma Protein ◽

Oral Bioavailability ◽

Prediction Models ◽

Human Plasma Protein ◽

Download Full-text

In Silico Prediction of Human Plasma Protein Binding Using Hologram QSAR

Letters in Drug Design & Discovery ◽

10.2174/157018007781788480 ◽

2007 ◽

Vol 4 (7) ◽

pp. 502-509 ◽

Author(s):

Tiago Moda ◽

Carlos Montanari ◽

Adriano Andricopulo

Keyword(s):

Protein Binding ◽

Human Plasma ◽

Plasma Protein Binding ◽

Plasma Protein ◽

In Silico ◽

In Silico Prediction ◽

Human Plasma Protein

Download Full-text

Evaluation of Human Plasma Protein Binding of Trabectedin (Yondelis™, ET-743)

Current Clinical Pharmacology ◽

10.2174/157488409787236047 ◽

2009 ◽

Vol 4 (1) ◽

pp. 38-42 ◽

Author(s):

Jan Beumer ◽

L. Lopez-Lazaro ◽

Jan Schellens ◽

Jos Beijnen ◽

Olaf Tellingen

Keyword(s):

Protein Binding ◽

Human Plasma ◽

Plasma Protein Binding ◽

Plasma Protein ◽

Human Plasma Protein

Download Full-text

QSAR Modeling Using Automatically Updating Correction Libraries: Application to a Human Plasma Protein Binding Model

Journal of Chemical Information and Modeling ◽

10.1021/ci700197x ◽

2007 ◽

Vol 47 (6) ◽

pp. 2401-2407 ◽

Author(s):

Sarah L. Rodgers ◽

Andrew M. Davis ◽

Nick P. Tomkinson ◽

Han van de Waterbeemd

Keyword(s):

Protein Binding ◽

Human Plasma ◽

Plasma Protein Binding ◽

Plasma Protein ◽

Qsar Modeling ◽

Binding Model ◽

Human Plasma Protein

Download Full-text

Improved solubility and pharmacokinetics of PEGylated liposomal honokiol and human plasma protein binding ability of honokiol

International Journal of Pharmaceutics ◽

10.1016/j.ijpharm.2011.03.003 ◽

2011 ◽

Vol 410 (1-2) ◽

pp. 169-174 ◽

Author(s):

Xian-Huo Wang ◽

Lu-Lu Cai ◽

Xiao-Yan Zhang ◽

Lin-Yu Deng ◽

Hao Zheng ◽

...

Keyword(s):

Protein Binding ◽

Human Plasma ◽

Plasma Protein Binding ◽

Plasma Protein ◽

Binding Ability ◽

Human Plasma Protein

Download Full-text

Rat and human plasma protein binding of die main metabolite of triflusal

European Journal of Pharmacology ◽

10.1016/0014-2999(90)92202-t ◽

1990 ◽

Vol 183 (5) ◽

pp. 1867-1868 ◽

Author(s):

J. Ramis ◽

R. Mis ◽

L. Conte ◽

J. Forn

Keyword(s):

Protein Binding ◽

Human Plasma ◽

Plasma Protein Binding ◽

Plasma Protein ◽

Main Metabolite ◽

Human Plasma Protein

Download Full-text

Effect of in vivo Increase of Free Fatty Acids on Human Plasma Protein Binding of Furosemide

Pharmacology ◽

10.1159/000137726 ◽

1982 ◽

Vol 25 (2) ◽

pp. 73-81 ◽

Author(s):

Roberto Colombo ◽

Arnaldo Pinelli

Keyword(s):

Fatty Acids ◽

Protein Binding ◽

Free Fatty Acids ◽

Human Plasma ◽

Plasma Protein Binding ◽

Plasma Protein ◽

Human Plasma Protein

Download Full-text