Rat and human plasma protein binding of die main metabolite of triflusal

1990 ◽  
Vol 183 (5) ◽  
pp. 1867-1868 ◽  
Author(s):  
J. Ramis ◽  
R. Mis ◽  
L. Conte ◽  
J. Forn
Keyword(s):  
Protein Binding ◽  
Human Plasma ◽  
Plasma Protein Binding ◽  
Plasma Protein ◽  
Main Metabolite ◽  
Human Plasma Protein

Evaluation of Human Plasma Protein Binding of Trabectedin (Yondelis™, ET-743)

2009 ◽  
Vol 4 (1) ◽  
pp. 38-42 ◽  
Author(s):  
Jan Beumer ◽  
L. Lopez-Lazaro ◽  
Jan Schellens ◽  
Jos Beijnen ◽  
Olaf Tellingen
Keyword(s):  
Protein Binding ◽  
Human Plasma ◽  
Plasma Protein Binding ◽  
Plasma Protein ◽  
Human Plasma Protein

Improved solubility and pharmacokinetics of PEGylated liposomal honokiol and human plasma protein binding ability of honokiol

2011 ◽  
Vol 410 (1-2) ◽  
pp. 169-174 ◽  
Author(s):  
Xian-Huo Wang ◽  
Lu-Lu Cai ◽  
Xiao-Yan Zhang ◽  
Lin-Yu Deng ◽  
Hao Zheng ◽  
...  
Keyword(s):  
Protein Binding ◽  
Human Plasma ◽  
Plasma Protein Binding ◽  
Plasma Protein ◽  
Binding Ability ◽  
Human Plasma Protein

Species differences in drug plasma protein binding

MedChemComm ◽  
2014 ◽  
Vol 5 (7) ◽  
pp. 963-967 ◽  
Author(s):  
Nicola Colclough ◽  
Linette Ruston ◽  
J. Matthew Wood ◽  
Philip A. MacFaul
Keyword(s):  
Drug Discovery ◽  
Protein Binding ◽  
Human Plasma ◽  
Plasma Protein Binding ◽  
Plasma Protein ◽  
Plasma Proteins ◽  
Species Differences ◽  
Human Plasma Protein ◽  
Binding Data ◽  
Drug Plasma

Comparison of the human plasma protein binding data for a variety of drug discovery compounds indicates that compounds tend to be slightly more bound to human plasma proteins, than compared to plasma proteins from rats, dogs or mice.

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