Evaluation of the exposure methodology for risk-benefit assessment of seafood consumption

Chemosphere ◽  
2008 ◽  
Vol 73 (10) ◽  
pp. 1582-1588 ◽  
Author(s):  
Isabelle Sioen ◽  
Jean-Charles Leblanc ◽  
Jean-Luc Volatier ◽  
Stefaan De Henauw ◽  
John Van Camp
Keyword(s):  
Benefit Assessment ◽  
Seafood Consumption ◽  
Risk Benefit Assessment

scholarly journals 1243Quantitative risk-benefit assessment of fish and seafood consumption scenarios to support recommendations

2021 ◽  
Vol 50 (Supplement_1) ◽  
Author(s):  
Catarina Carvalho ◽  
Daniela Correia ◽  
Milton Severo ◽  
Cláudia Afonso ◽  
Narcisa M. Bandarra ◽  
...  
Keyword(s):  
Pregnant Women ◽  
Health Gain ◽  
Benefit Assessment ◽  
Mercury Species ◽  
Seafood Consumption ◽  
Tolerable Weekly Intake ◽  
Health Gains ◽  
Life Years ◽  
Risk Benefit Assessment ◽  
Alternative Scenarios

Abstract Background Fish/seafood consumption has health benefits, namely due to its omega-3 fatty acids levels and risks due to methylmercury contamination. This study aims to quantify the health impact of hypothetical scenarios of fish/seafood consumption through a risk-benefit assessment and provide support for recommendations, using Portuguese food consumption data. Methods We used data from the National Food, Nutrition and Physical Activity Survey 2015-2016 (n = 5811) to estimate the mean exposure to methylmercury and EPA+DHA in the current and alternative scenarios. Alternative scenarios were modelled using probabilistic approaches to reflect substitutions from the current consumption in the type of fish/seafood (predatory vs low-mercury species) or its frequency (1-7x/week). The overall scenarios’ impact was quantified using Disability-Adjusted Life Years (DALYs). Results About 14% of the Portuguese population exceeds the methylmercury tolerable weekly intake, and this prevalence is higher among small children (36.6%). Nevertheless, if the fish/seafood consumption increased to once a day, ≈11450 DALYs could be prevented each year. However, such a scenario would result in higher risk for pregnant women (1398 extra DALYs). Moreover, excluding predatory species consumption resulted in small but significant health gains (-1078 DALYs). Conclusions For the general population, the maximum health gains are obtained by consuming fish/seafood up to 7x/week, but among children and pregnant women, the frequency should be limited to 3-5x/week. All population should preferably choose non-predatory species. Key messages Daily fish consumption results in the highest overall populational health gain, but children and pregnant women need to limit it to 3-5x/week, due to methylmercury exposure.

Quantitative risk-benefit assessment of Portuguese fish and other seafood species consumption scenarios

2021 ◽  
pp. 1-32
Author(s):  
Catarina Carvalho ◽  
Daniela Correia ◽  
Milton Severo ◽  
Cláudia Afonso ◽  
Narcisa M. Bandarra ◽  
...  
Keyword(s):  
Pregnant Women ◽  
Health Impact ◽  
Daily Basis ◽  
Benefit Assessment ◽  
Seafood Consumption ◽  
Portuguese Population ◽  
Life Years ◽  
Risk Benefit Assessment ◽  
Alternative Scenarios ◽  
Predatory Fishes

Abstract Portugal has high fish/seafood consumption, which may have both risks and benefits. This study aims to quantify the net health impact of hypothetical scenarios of fish/seafood consumption in the Portuguese population using a risk-benefit assessment methodology. Consumption data from the National Food, Nutrition and Physical Activity Survey 2015-2016 (n=5811) was used to estimate the mean exposure to methylmercury and EPA+DHA in the current and the alternative scenarios considered. Alternative scenarios (alt) were modelled using probabilistic approaches to reflect substitutions from the current consumption in the type of fish/seafood (alt1: excluding predatory fishes; alt2: including only methylmercury low-level fishes) or in the frequency of weekly fish/seafood consumption (alt3 to alt6: 1,3,5 or 7 times a week, replacing fish/seafood meals with meat or others). The overall health impact of these scenarios was quantified using Disability-Adjusted Life Years (DALYs). In the Portuguese population, about 11450 DALYs could be prevented each year if the fish/seafood consumption increased to a daily basis. However, such a scenario would result in 1398 extra DALYs considering the consumption by pregnant women and the respective risk on foetal neurodevelopment. Our findings support a recommendation to increase fish/seafood consumption up to 7 times/week. However, for pregnant women and children, special considerations must be proposed to avoid potential risks on foetal neurodevelopment due to methylmercury exposure.

scholarly journals Differences between the European Union and United States of America in Drug Regulatory Affairs Affect Global Patient Safety Standards and Public Health Awareness: The Case of Deferasirox and Other Iron Chelating Drugs

Medicines ◽  
2021 ◽  
Vol 8 (7) ◽  
pp. 36
Author(s):  
George J. Kontoghiorghes
Keyword(s):  
Patient Safety ◽  
Generic Drugs ◽  
Benefit Assessment ◽  
Regulatory Control ◽  
Pharmaceutical Companies ◽  
The European Union ◽  
Regulatory Policies ◽  
Regulatory Affairs ◽  
Risk Benefit Assessment ◽  
The Eu

Regulatory policies on drugs have a major impact on patient safety and survival. Some pharmaceutical companies employ all possible methods to achieve maximum sales in relation to the monopoly of their patented drugs, leading sometimes to irregularities and illegal activities. Misinformation on the orphan drug deferasirox has reached the stage of criminal investigations and fines exceeding USD 100 million. Additional lawsuits of USD 3.5 billion for damages and civil fines were also filed by the FBI of the USA involving deferasirox and mycophenolic acid, which were later settled with an additional fine of USD 390 million. Furthermore, a USD 345 million fine was also settled for bribes and other illegal overseas operations including an EU country. However, no similar fines for illegal practises or regulatory control violations have been issued in the EU. Misconceptions and a lack of clear guidelines for the use of deferasirox in comparison to deferiprone and deferoxamine appear to reduce the effective treatment prospects and to increase the toxicity risks for thalassaemia and other iron loaded patients. Similar issues have been raised for the activities of other pharmaceutical companies promoting the use of new patented versus generic drugs. Treatments for different categories of patients using new patented drugs are mostly market driven with no clear safeguards or guidelines for risk/benefit assessment indications or for individualised effective and safe optimum therapies. There is a need for the establishment of an international organisation, which can monitor and assess the risk/benefit assessment and marketing of drugs in the EU and globally for the benefit of patients. The pivotal role of the regulatory drug authorities and the prescribing physicians for identifying individualised optimum therapies is essential for improving the survival and safety of millions of patients worldwide.

Development and Application of a Probabilistic Risk-Benefit Assessment Model for Infant Feeding Integrating Microbiological, Nutritional, and Chemical Components

Risk Analysis ◽  
2017 ◽  
Vol 37 (12) ◽  
pp. 2360-2388 ◽  
Author(s):  
Géraldine Boué ◽  
Enda Cummins ◽  
Sandrine Guillou ◽  
Jean-Philippe Antignac ◽  
Bruno Le Bizec ◽  
...  
Keyword(s):  
Infant Feeding ◽  
Assessment Model ◽  
Benefit Assessment ◽  
Chemical Components ◽  
Risk Benefit Assessment ◽  
Probabilistic Risk

Risk-Benefit Assessment of Antiarrhythmic Drugs

Drug Safety ◽  
1991 ◽  
Vol 6 (5) ◽  
pp. 323-331 ◽  
Author(s):  
Lawrence Friedman ◽  
Eleanor Schron ◽  
Salim Yusuf
Keyword(s):  
Antiarrhythmic Drugs ◽  
Benefit Assessment ◽  
Risk Benefit Assessment

A Risk-Benefit Assessment of Mirtazapine in the Treatment of Depression

Drug Safety ◽  
1997 ◽  
Vol 17 (4) ◽  
pp. 251-264 ◽  
Author(s):  
Siegfried Kasper ◽  
Nicole Praschak-Rieder ◽  
Johannes Tauscher ◽  
Rainer Wolf
Keyword(s):  
Benefit Assessment ◽  
Treatment Of Depression ◽  
Risk Benefit Assessment

scholarly journals Risk-benefit assessment of ivabradine in the treatment of chronic heart failure

2014 ◽  
pp. 47
Author(s):  
Pawel Ptaszynski ◽  
Irmina Urbanek ◽  
Krzysztof Kaczmarek ◽  
Iwona Cygankiewicz
Keyword(s):  
Heart Failure ◽  
Chronic Heart Failure ◽  
Benefit Assessment ◽  
Risk Benefit Assessment

scholarly journals Essential nutrient element profiles in rice types: a risk–benefit assessment including inorganic arsenic

2021 ◽  
pp. 1-12
Author(s):  
Manoj Menon ◽  
Amelia Smith ◽  
Joseph Fennell
Keyword(s):  
Wild Rice ◽  
Brown Rice ◽  
Reference Value ◽  
Inorganic Arsenic ◽  
Benefit Assessment ◽  
Nutrient Element ◽  
Risk Benefit Assessment ◽  
Rice Consumption ◽  
Significant Pathway ◽  
The Uk

Abstract Rice is consumed by nearly half of the global population and a significant source of energy and nutrients. However, rice consumption can also be a significant pathway of inorganic arsenic (iAs) exposure, thus requiring a risk–benefit assessment. This study assessed nutrient element (NE) densities in fifty-five rice types (white, brown and wild rice) marketed in the UK. Densities of essential NE were used to rank rice types in meeting daily NE targets under different consumption scenarios through a newly developed optimisation approach. Using iAs data from these rice types, we assessed the margin of exposure (MOE) for low (the UK) and high (Bangladesh) rice intake scenarios. Our results showed that brown and wild rice are significantly higher in many NE and significantly contribute to dietary reference value (DRV). Our modelling showed that switching to brown or wild rice could increase the intake of several essential nutrients by up to eight times that of white rice. Using rice consumption data for mid-to-high-consumption countries, we estimate that brown rice could provide 100 % adult DRV for Fe, Mg, Cr, P and Mo, and substantial contributions for Zn, Se and K. Our results show that the amount of rice primarily determines risk from iAs consumed rather than the type of rice. Therefore, switching from white to brown or wild rice could be beneficial, provided iAs concentration in rice is within the recommended limits.

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