Synthesis of a dipeptide by integrating a continuous flow reaction and continuous crystallization

Author(s):  
Masashi Tanaka ◽  
Masahiro Hosoya ◽  
Atsushi Manaka ◽  
Naoki Tsuno
2010 ◽  
Vol 312 (24) ◽  
pp. 3613-3618 ◽  
Author(s):  
Hiromichi Hayashi ◽  
Takio Noguchi ◽  
Nazrul M. Islam ◽  
Yukiya Hakuta ◽  
Yusuke Imai ◽  
...  

2018 ◽  
Vol 266 ◽  
pp. 249-258 ◽  
Author(s):  
Maria Romero-Fernández ◽  
Sonia Moreno-Perez ◽  
Alejandro H. Orrego ◽  
Sandro Martins de Oliveira ◽  
Ramón I. Santamaría ◽  
...  

Synlett ◽  
2020 ◽  
Vol 31 (05) ◽  
pp. 497-501 ◽  
Author(s):  
Koichiro Masuda ◽  
Yao Wang ◽  
Shun-ya Onozawa ◽  
Shigeru Shimada ◽  
Nagatoshi Koumura ◽  
...  

Rose Bengal was immobilized on a vinylimidazolium functionalized support, and the heterogeneous organic photosensitizer thus prepared was applied for photooxidation reactions of organic molecules under continuous-flow conditions. Substituents of the cation part of the support were found to play a crucial role in determining the lifetime of the catalyst. More than 11 days continuous operation of a flow reaction was achieved.


2016 ◽  
Vol 12 ◽  
pp. 2511-2522 ◽  
Author(s):  
Olga C Dennehy ◽  
Valérie M Y Cacheux ◽  
Benjamin J Deadman ◽  
Denis Lynch ◽  
Stuart G Collins ◽  
...  

A continuous process strategy has been developed for the preparation of α-thio-β-chloroacrylamides, a class of highly versatile synthetic intermediates. Flow platforms to generate the α-chloroamide and α-thioamide precursors were successfully adopted, progressing from the previously employed batch chemistry, and in both instances afford a readily scalable methodology. The implementation of the key α-thio-β-chloroacrylamide casade as a continuous flow reaction on a multi-gram scale is described, while the tuneable nature of the cascade, facilitated by continuous processing, is highlighted by selective generation of established intermediates and byproducts.


2014 ◽  
Vol 43 (4) ◽  
pp. 535-537 ◽  
Author(s):  
Toshinori Shimanouchi ◽  
Shouhei Ueno ◽  
Kazuki Shidahara ◽  
Yukitaka Kimura

2018 ◽  
Vol 3 (1) ◽  
pp. 94-101 ◽  
Author(s):  
Kosi C. Aroh ◽  
Klavs F. Jensen

Transient temperature and flowrates in continuous flow reaction systems allows for the rapid generation of kinetic data.


2010 ◽  
Vol 312 (12-13) ◽  
pp. 1968-1972 ◽  
Author(s):  
Hiromichi Hayashi ◽  
Takio Noguchi ◽  
Nazrul M. Islam ◽  
Yukiya Hakuta ◽  
Yusuke Imai ◽  
...  

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