NEW REFERENCE EQUATIONS FOR IMPULSE OSCILLOMETRY

Abstract Background Impulse oscillometry (IOS) is important in diagnosing respiratory functions in non-cooperative children. Studies are rising nowadays to establish reliable reference values of IOS for children of different ethnicities. No available data about the regression equations for parameters of IOS for Egyptian children and adolescents. So, our study aimed to develop regression equations for parameters of IOS in Egyptian children and adolescents in relation to their age, weight, height, and body mass index. Results Height and age affected the regression equation of impedance at 5 Hz (Z5 Hz) and resistance at 5 Hz (R5 Hz) in both males and females, resistance at 20 Hz (R20 Hz) in males and reactance at 5 Hz (X5 Hz) in females. Height affected the regression equation of R20 Hz in females, resonant frequency (Fres) in males, and the area of reactance (AX) in both males and females. While age affected the equation of X5 Hz in males and Fres in males. Conclusions Height and age were the most predictive values affecting the regression equation of IOS in Egyptian children and adolescents.

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Reference values of respiratory impedance with impulse oscillometry in healthy Chinese adults

10.21203/rs.3.rs-99501/v1 ◽

2020 ◽

Author(s):

Xiaolin Liang ◽

Yi Gao ◽

Weijie Guan ◽

Jing Du ◽

Li Chen ◽

...

Keyword(s):

Final Analysis ◽

Specific Reference ◽

Respiratory Impedance ◽

Impulse Oscillometry ◽

Chinese Adults ◽

European Respiratory Society ◽

Clinical Trial Registration ◽

Normal Ranges ◽

Normal Individuals ◽

Reference Equations

Abstract Background: Impulse oscillometry (IOS) is a non-invasive pulmonary function test for measuring respiratory impedance. Available reference equations of IOS indices for adults are limited. The aim of this study was to develop reference equations of IOS indices for Chinese adults.Methods: In a multicentral, cross-sessional study of impulse oscillometry in Chinese adults, IOS data from healthy subjects were collected from 19 general hospitals across China was between 2016 and 2018. IOS measurements were conducted in accordance with recommendations of the European Respiratory Society. Multiple linear regression was performed to develop sex-specific reference equations of IOS indices.Results: IOS measurements were performed in 1318 subjects, of which 567 subjects were defined as healthy normal individuals with acceptable IOS data and were included in the final analysis. Reference equations and limits of normal (LLN/ULN) of IOS indices were developed separately for males and females. Height but not age was shown to be the most influential contributor to IOS indices. The reference equations currently used in lung function laboratories predicted higher R5 and X5. Normal ranges of R5 and X5 recommended by the equipment manufacturer were clearly different from the ULN/LLN derived from the reference equations.Conclusions: Reference equations of IOS indices for Chinese adults from a wide region were provided in this study. It is necessary to update new IOS reference equations and adopt ULN/LLN as normal ranges of IOS indices.Clinical Trial Registration: This study was registered at www.clinicaltrials.gov as part of a larger study NCT03467880.

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Validating Reference Equations for Impulse Oscillometry in Healthy Mexican Children

Respiratory Care ◽

10.4187/respcare.05247 ◽

2017 ◽

Vol 62 (9) ◽

pp. 1156-1165 ◽

Cited By ~ 3

Author(s):

Laura Gochicoa-Rangel ◽

Rodrigo del Río-Hidalgo ◽

Juana Hernández-Ruiz ◽

Luis Rodríguez-Moreno ◽

David Martínez-Briseño ◽

...

Keyword(s):

Impulse Oscillometry ◽

Mexican Children ◽

Reference Equations

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Reference equations for impulse oscillometry system parameters in Brazilian healthy children and adolescents

Physiotherapy ◽

10.1016/j.physio.2015.03.3478 ◽

2015 ◽

Vol 101 ◽

pp. e645-e646

Author(s):

C. Isabel Santos Schivinski ◽

M. Seabra de Assumpção ◽

R. Maba Gonçalves ◽

R. Martins ◽

T. Godoy Bobbio

Keyword(s):

Children And Adolescents ◽

Healthy Children ◽

Impulse Oscillometry ◽

System Parameters ◽

Reference Equations

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Impulse oscillometry for detection of small airway dysfunction in subjects with chronic respiratory symptoms and preserved pulmonary function

Respiratory Research ◽

10.1186/s12931-021-01662-7 ◽

2021 ◽

Vol 22 (1) ◽

Cited By ~ 2

Author(s):

Liang-Yuan Li ◽

Tian-Sheng Yan ◽

Jing Yang ◽

Yu-Qi Li ◽

Lin-Xi Fu ◽

...

Keyword(s):

Pulmonary Function ◽

Respiratory Symptoms ◽

Early Stage ◽

Roc Curves ◽

Diagnostic Value ◽

Small Airway ◽

Impulse Oscillometry ◽

Additional Method ◽

Cutoff Values ◽

Higher Sensitivity

Abstract Background Subjects with chronic respiratory symptoms and preserved pulmonary function (PPF) may have small airway dysfunction (SAD). As the most common means to detect SAD, spirometry needs good cooperation and its reliability is controversial. Impulse oscillometry (IOS) may complete the deficiency of spirometry and have higher sensitivity. We aimed to explore the diagnostic value of IOS to detect SAD in symptomatic subjects with PPF. Methods The evaluation of symptoms, spirometry and IOS results in 209 subjects with chronic respiratory symptoms and PPF were assessed. ROC curves of IOS to detect SAD were analyzed. Results 209 subjects with chronic respiratory symptoms and PPF were included. Subjects who reported sputum had higher R5–R20 and Fres than those who didn’t. Subjects with dyspnea had higher R5, R5–R20 and AX than those without. CAT and mMRC scores correlated better with IOS parameters than with spirometry. R5, R5–R20, AX and Fres in subjects with SAD (n = 42) significantly increased compared to those without. Cutoff values for IOS parameters to detect SAD were 0.30 kPa/L s for R5, 0.015 kPa/L s for R5–R20, 0.30 kPa/L for AX and 11.23 Hz for Fres. Fres has the largest AUC (0.665, P = 0.001) among these parameters. Compared with spirometry, prevalence of SAD was higher when measured with IOS. R5 could detect the most SAD subjects with a prevalence of 60.77% and a sensitivity of 81% (AUC = 0.659, P = 0.002). Conclusion IOS is more sensitive to detect SAD than spirometry in subjects with chronic respiratory symptoms and PPF, and it correlates better with symptoms. IOS could be an additional method for SAD detection in the early stage of diseases.

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