scholarly journals Regulatory effect of traditional Chinese medicines on signaling pathways of process from chronic atrophic gastritis to gastric cancer

2021 ◽  
Author(s):  
Xin-nan Liu ◽  
Shu-ping Wang ◽  
Jing-yang Li ◽  
Jing-ze Zhang ◽  
Dai-lin Liu
Keyword(s):  
Gastric Cancer ◽  
Atrophic Gastritis ◽  
Signaling Pathways ◽  
Chronic Atrophic Gastritis ◽  
Traditional Chinese Medicines ◽  
Regulatory Effect ◽  
Chinese Medicines

scholarly journals Effect of Monotherapy Weifuchun Tablets on Chronic Atropic Gastritis: A Randomized Controlled Trial

2021 ◽  
Author(s):  
Jiamin He ◽  
Weiyi Shen ◽  
Yawen Zhang ◽  
Mengjia Hu ◽  
Yanfei Fang ◽  
...  
Keyword(s):  
Folic Acid ◽  
Atrophic Gastritis ◽  
Chronic Atrophic Gastritis ◽  
Pathological Response ◽  
Pathological Examination ◽  
Control Group ◽  
Gastric Disease ◽  
Traditional Chinese Medicines ◽  
Chinese Medicines ◽  
H Pylori

Abstract Background and Aim: Chronic atrophic gastritis is a common gastric disease which shows a positive correlation with the occurrence of gastric cancer. Traditional chinese medicines have been used in the treatment of chronic atrophic gastritis. There is no solid evidence for the curative effects of traditional chinese medicines. This study aimed to investigate the clinical efficacy of Weifuchun tablets on patients with chronic atrophic gastritis. Methods 97 patients of chronic atrophic gastritis without current H. pylori infection were divided into two groups: an experiment group treated with Weifuchun and a control group treated with teprenone and folic acid for six months. Pathological examination of gastric biopsies and clinical symptoms assessment were performed for all patients before and after treatments. Primary outcome was the pathological response rate in each group evaluated by changes of histological scores.Secondary outcome was the clinical symptom scores. Results Twenty four patients in the Weifuchun group and twenty eight patients in the control group completed the study. The pathological response rates for atrophy and intestinal metaplasia were 66.7% and 45.8% in the Weifuchun group and 66.7% and 42.9% in the folic acid group, respectively, without statistical significance between groups.Clinical symptoms failed to improve after treatments in either group. Conclusions Weifuchun is effective to improve pathological changes of chronic atrophic gastritis in patients without current H. pylori infection. Monotherapy of Weifuchun had a similar efficacy to the combined therapy by teprenone and folic acid in the treatment of chronic atrophic gastritis. Trial registration: Evaluation of Weifuchun Pills on chronic atrophic gastritis, ChiCTR-IPR-17013939, Registered 15 December 2017, http://www.chictr.org.cn/ showproj.aspx?proj = 23910.

scholarly journals Progression from Chronic Atrophic Gastritis to Gastric Cancer; Tangle, Toggle, Tackle with Korea Red Ginseng

2010 ◽  
Vol 46 (3) ◽  
pp. 195-204 ◽  
Author(s):  
Yoon Jae Kim ◽  
Jun Won Chung ◽  
So Jung Lee ◽  
Ki Seok Choi ◽  
Ju Hyun Kim ◽  
...  
Keyword(s):  
Gastric Cancer ◽  
Atrophic Gastritis ◽  
Chronic Atrophic Gastritis ◽  
Red Ginseng ◽  
Korea Red Ginseng

Chronic atrophic gastritis and gastric cancer

2000 ◽  
Vol 32 (6) ◽  
pp. 544 ◽  
Author(s):  
G. Testino ◽  
M. Valentini ◽  
M. Cornaggia ◽  
R. Testino
Keyword(s):  
Gastric Cancer ◽  
Atrophic Gastritis ◽  
Chronic Atrophic Gastritis

Serum anti-helicobacter pylori antibodies and the risk of chronic atrophic gastritis and gastric cancer

2000 ◽  
Vol 118 (4) ◽  
pp. A760
Author(s):  
Chiao-Jung Tsai ◽  
Zuo-Feng Zhang ◽  
Guo-Pei Yu ◽  
Robert C. Kurtz
Keyword(s):  
Gastric Cancer ◽  
Helicobacter Pylori ◽  
Atrophic Gastritis ◽  
Chronic Atrophic Gastritis

scholarly journals Risk factors for development of gastric cancer in chronic atrophic gastritis: A long-term follow-up study

2018 ◽  
Vol 26 (31) ◽  
pp. 1812-1817 ◽  
Author(s):  
Hua-Ying Zhang ◽  
Xin-Yu Huang ◽  
Hui-Guang Xue ◽  
Ai-Hua Yang ◽  
Xue-Guo Sun ◽  
...  
Keyword(s):  
Risk Factors ◽  
Gastric Cancer ◽  
Atrophic Gastritis ◽  
Chronic Atrophic Gastritis ◽  
Follow Up Study ◽  
Long Term Follow Up ◽  
Development Of Gastric Cancer

scholarly journals Trefoil Factor Family in Pre-neoplastic Lesions and Gastric Cancer

2018 ◽  
Vol 4 ◽  
Author(s):  
Zahra Behrooznia ◽  
Pouya Ghaderi ◽  
Narges Jafarzadeh ◽  
Azra Izanloo ◽  
Sepideh Mansoori Majoofardi ◽  
...  
Keyword(s):  
Gastric Cancer ◽  
Gastrointestinal Tract ◽  
Atrophic Gastritis ◽  
Intestinal Metaplasia ◽  
Chronic Atrophic Gastritis ◽  
Suppressor Activity ◽  
Neoplastic Lesions ◽  
Tumor Suppressor Activity ◽  
Trefoil Factor Family

Gastric cancer is the fourth most common cancer and the second leading cause of cancer death worldwide. Although the global incidence of gastric cancer has been decreased dramatically in recent decades, north and northwest of Iran have the highest incidence rate of gastric cancer. Whilst the surgical procedures for gastric cancer have been improved, there is no cure for that. The intestinal type of GC results from pre-neoplastic conditions including atrophic gastritis, intestinal metaplasia and dysplasia. Trefoil Factors Family proteins (TFFs) are small and stable molecules secreted by the mammalian gastrointestinal tract. TFFs constitute a family of three peptides (TFF1, TFF2and TFF3) that are widely expressed in a tissue specific manner in the gastrointestinal tract. Variable TFFs expression in gastric cancer and pre-neoplastic lesions has been found. TFF1 has a tumor suppressor activity and inhibits tumorogenesis in gastric cancer. Its expression decreases in gastritis, gastric atrophy, dysplasia, intestinal metaplasia and gastric cancer.TFF2 has a protective effect on gastrointestinal epithelium. As a prognostic factor, TFF2 expression decreases in gastric ulcer, chronic atrophic gastritis and gastric cancer. TFF3 is considered as an oncogenic factor in gastric tissues. Whilst the normal gastric tissues don’t express TFF3, it increases in intestinal metaplasia. Therefore, more studies are necessary to clarify the role of TFFs in GC and pre-neoplastic conditions. This review has focused on elucidating the important role of TFFs in gastric cancer and pre-neoplastic lesions.

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