Online concentration of aristolochic acid I and II in Chinese medicine preparations by micellar electrokinetic chromatography

2007 ◽  
Vol 1167 (1) ◽  
pp. 120-124 ◽  
Author(s):  
Shenhua Shi ◽  
Wei Li ◽  
Yiping Liao ◽  
Zongwei Cai ◽  
Huwei Liu
Keyword(s):  
Chinese Medicine ◽  
Micellar Electrokinetic Chromatography ◽  
Aristolochic Acid ◽  
Electrokinetic Chromatography ◽  
Aristolochic Acid I

scholarly journals Traditional Chinese medicine: Pivotal role of the spleen in the metabolism of aristolochic acid I in rats is dependent on oatp2a1

2016 ◽  
Vol 14 (4) ◽  
pp. 3243-3250 ◽  
Author(s):  
Ting Xiang ◽  
Zhangbin Yang ◽  
Baoguo Sun ◽  
Haoxuan Luo ◽  
Shijun Zhang ◽  
...  
Keyword(s):  
Chinese Medicine ◽  
Traditional Chinese Medicine ◽  
Aristolochic Acid ◽  
Pivotal Role ◽  
Aristolochic Acid I

scholarly journals Rapid Analysis of Aristolochic Acid Analogues in Traditional Chinese Patent Medicine by LC-MS/MS

2020 ◽  
Vol 2020 ◽  
pp. 1-7
Author(s):  
Jing Liu ◽  
Yang Liu ◽  
Yingxue Wu ◽  
Zhong Dai ◽  
Shuangcheng Ma
Keyword(s):  
Chinese Medicine ◽  
Traditional Chinese Medicine ◽  
Aristolochic Acid ◽  
Gene Mutations ◽  
Aristolochic Acids ◽  
Potential Safety ◽  
Akebiae Caulis ◽  
The One ◽  
Traditional Chinese Patent Medicine ◽  
Aristolochic Acid I

Aristolochic acids have been demonstrated to have renal toxicity, cause carcinogenesis, and may cause gene mutations. A series of risk control measurements have been adopted worldwide since 1990s. Some varieties of traditional Chinese medicine with high content of aristolochic acids have been banned in China. However, some species containing aristolochic acids in microscale are still in use. In recent years, with the continuous awareness of drug safety, the aristolochic acid analogues were generally considered to be of potential safety risks. Among these constituents, aristolochic acid I is still the one with most studies. Therefore, in addition to aristolochic acid I, it is necessary to establish an accurate and rapid method to determine other aristolochic acid analogues. LC-MS/MS methods based on multireaction monitoring mode was established to simultaneously determine 9 aristolochic acid analogues including 5 aristolochic acids and 4 aristolactams for the first time. Furthermore, the method was applied for Long dan Xie gan Pill, a traditional complex compound preparation with a long history for treatment of diseases including hepatochlic hygropyrexia, dizziness, tinnitus, and deafness. It has attracted widespread attention because of the aristolochic acid nephropathy. The crude drug Caulis Aristolochiae manshuriensis (Guanmutong) collected in the prescription was replaced by Akebiae Caulis (Mutong), and the established method helps to understand the product safety on market. As a result, aristolochic acid I, aristolochic acid Iva, and aristolactam I were detected and determined in one batch of Long dan Xie gan Pill among 25 batches of samples. It provided practical approach to demonstrate trace aristolochic acids and aristolactams. It was beneficial to control the safety of related traditional Chinese medicine products.

Determination of Aristolochic Acid I and II in Traditional Chinese Medicine by HPCE with Label Free Intrinsic Imaging

2009 ◽  
Vol 70 (3-4) ◽  
pp. 467-473 ◽  
Author(s):  
A. Aboel Dahab ◽  
N. W. Smith ◽  
N. Marlin
Keyword(s):  
Chinese Medicine ◽  
Traditional Chinese Medicine ◽  
Aristolochic Acid ◽  
Label Free ◽  
Intrinsic Imaging ◽  
Aristolochic Acid I

Lupane Type Triterpene Isolated from the Leaves of Thecacoris Annobonea (Euphorbiaceae)

2013 ◽  
Vol 12 (10) ◽  
pp. 695-701
Author(s):  
Herve Martial Poumale Poumale ◽  
Alphonsine Nkapwa Guedem ◽  
Louis Pergaud Sandjo ◽  
Bonaventure Tchaleu Ngadjui ◽  
Yoshihito Shiono
Keyword(s):  
Antimicrobial Activity ◽  
Root Growth ◽  
Betulinic Acid ◽  
Aristolochic Acid ◽  
2D Nmr ◽  
Aristolochic Acid I

A new lupane type triterpene (1), together with betulinic acid (2), friedelin (3), aristolochic acid I (4), alpinumisoflavone (5) and 4’-O-methylepinumisoflavone (6) have been isolated from the leaves of Thecacoris annobonea. The structure of the new compound was elucidated on the basis of 1 and 2D NMR experiments. The isolated compounds were evaluated for their phytotoxicity and antimicrobial activity. 1 exhibited significant antimicrobial activity at 30 μg/ml and compounds 1, 2, 3, 4, 5 and 6 inhibited root growth lettuce at 100 μg/ml. 

Determination of Imipenem and Cilastatin in Medicinal Products by Micellar Electrokinetic Chromatography

2017 ◽  
Vol 13 (2) ◽  
pp. 158-166 ◽  
Author(s):  
Tyski Stefan ◽  
Gruba Ewa ◽  
Bukowska Bozena ◽  
Michalska Katarzyna ◽  
Karpiuk Izabela
Keyword(s):  
Micellar Electrokinetic Chromatography ◽  
Electrokinetic Chromatography ◽  
Medicinal Products

Quantitative Analysis of Duloxetine and 1-Naphthol by Capillary Micellar Electrokinetic Chromatography

2011 ◽  
Vol 7 (3) ◽  
pp. 184-193 ◽  
Author(s):  
Nathalie R. Wingert ◽  
Aline B. Barth ◽  
Patricia Gomes ◽  
Elfrides E. S. Shapoval ◽  
Martin Steppe
Keyword(s):  
Quantitative Analysis ◽  
Micellar Electrokinetic Chromatography ◽  
Electrokinetic Chromatography

Sequential micellar electrokinetic chromatography analysis of racemization reaction of alanine enantiomers

2014 ◽  
Vol 1331 ◽  
pp. 123-128 ◽  
Author(s):  
Rao Fu ◽  
Lina Liu ◽  
Yingna Guo ◽  
Liping Guo ◽  
Li Yang
Keyword(s):  
Micellar Electrokinetic Chromatography ◽  
Electrokinetic Chromatography ◽  
Chromatography Analysis
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