Rapid and high-resolution glycoform profiling of recombinant human erythropoietin by capillary isoelectric focusing with whole column imaging detection

2008 ◽  
Vol 1190 (1-2) ◽  
pp. 372-376 ◽  
Author(s):  
Peng Dou ◽  
Zhen Liu ◽  
Jiangang He ◽  
Jing-Juan Xu ◽  
Hong-Yuan Chen
Keyword(s):  
High Resolution ◽  
Isoelectric Focusing ◽  
Recombinant Human Erythropoietin ◽  
Capillary Isoelectric Focusing ◽  
Human Erythropoietin ◽  
Imaging Detection

Interlaboratory method validation of imaged capillary isoelectric focusing methodology for analysis of recombinant human erythropoietin

2020 ◽  
Vol 12 (30) ◽  
pp. 3836-3843
Author(s):  
Xiang Li ◽  
Xingchang Shi ◽  
Xi Qin ◽  
Lei Yu ◽  
Yong Zhou ◽  
...  
Keyword(s):  
Method Validation ◽  
Isoelectric Focusing ◽  
Recombinant Human Erythropoietin ◽  
Capillary Isoelectric Focusing ◽  
Human Erythropoietin

Recombinant human erythropoietin (rhEPO) is one of the most important biopharmaceuticals worldwide, with global sales expected to reach US$11.9 billion in 2020.

An improved capillary isoelectric focusing-mass spectrometry method for high-resolution characterization of monoclonal antibody charge variants

2022 ◽  
Author(s):  
Tian Xu ◽  
Linjie Han ◽  
Alayna M. George Thompson ◽  
Liangliang Sun
Keyword(s):  
Mass Spectrometry ◽  
Monoclonal Antibody ◽  
High Resolution ◽  
Isoelectric Focusing ◽  
Capillary Isoelectric Focusing ◽  
Spectrometry Method ◽  
Mass Spectrometry Method ◽  
Charge Variants

Routine and high-resolution characterization of monoclonal antibody (mAb) charge variants is vital for controlling mAb quality as therapeutics. Capillary isoelectric focusing-mass spectrometry (cIEF-MS) has emerged as a powerful tool for...

Fluorescence imaging detection for capillary isoelectric focusing

1995 ◽  
Vol 16 (1) ◽  
pp. 1474-1478 ◽  
Author(s):  
Xing-Zheng Wu ◽  
Jiaqi Wu ◽  
Janusz Pawliszyn
Keyword(s):  
Fluorescence Imaging ◽  
Isoelectric Focusing ◽  
Capillary Isoelectric Focusing ◽  
Imaging Detection
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