Modeling of two semi-continuous methods in liquid–liquid chromatography: Comparing conventional and closed-loop recycling modes

2020 ◽  
Vol 1614 ◽  
pp. 460735 ◽  
Author(s):  
Artak Kostanyan ◽  
Maria Martynova
Keyword(s):  
Liquid Chromatography ◽  
Closed Loop ◽  
Continuous Methods

scholarly journals Automated Solubility Screening Platform Using Computer Vision

2020 ◽  
Author(s):  
Parisa Shiri ◽  
Veronica Lai ◽  
Tara Zepel ◽  
Daniel Griffin ◽  
Jonathan Reifman ◽  
...  
Keyword(s):  
Computer Vision ◽  
High Performance Liquid Chromatography ◽  
Liquid Chromatography ◽  
High Performance ◽  
Closed Loop ◽  
Manual Labour ◽  
Solvent Systems ◽  
Screening Platform ◽  
Iterative Feedback ◽  
User Intervention

<p>Solubility screening is an essential, routine process that is often labour intensive. Robotic platforms have been developed to automate some aspects of the manual labour involved. However, many of the existing systems rely on traditional analytic techniques such as High Performance Liquid Chromatography or HPLC, which require pre-calibration for each compound and can be prohibitively expensive. In addition, automation is not typically end-to-end, requiring user intervention to move vials, establish analytical methods for each compound and interpret the raw data. We developed a closed-loop, flexible robotics system with integrated solid and liquid dosing capabilities that relies on computer vision and iterative feedback to successfully measure caffeine solubility in multiple solvents. After initial researcher input (<2 min), the system ran autonomously, screening five different solvent systems (20-80 min each). The resulting data matched values obtained using traditional manual techniques.</p>

scholarly journals Automated Solubility Screening Platform Using Computer Vision

2020 ◽  
Author(s):  
Parisa Shiri ◽  
Veronica Lai ◽  
Tara Zepel ◽  
Daniel Griffin ◽  
Jonathan Reifman ◽  
...  
Keyword(s):  
Computer Vision ◽  
High Performance Liquid Chromatography ◽  
Liquid Chromatography ◽  
High Performance ◽  
Closed Loop ◽  
Manual Labour ◽  
Solvent Systems ◽  
Screening Platform ◽  
Iterative Feedback ◽  
User Intervention

<p>Solubility screening is an essential, routine process that is often labour intensive. Robotic platforms have been developed to automate some aspects of the manual labour involved. However, many of the existing systems rely on traditional analytic techniques such as High Performance Liquid Chromatography or HPLC, which require pre-calibration for each compound and can be prohibitively expensive. In addition, automation is not typically end-to-end, requiring user intervention to move vials, establish analytical methods for each compound and interpret the raw data. We developed a closed-loop, flexible robotics system with integrated solid and liquid dosing capabilities that relies on computer vision and iterative feedback to successfully measure caffeine solubility in multiple solvents. After initial researcher input (<2 min), the system ran autonomously, screening five different solvent systems (20-80 min each). The resulting data matched values obtained using traditional manual techniques.</p>

Intestinal Bacteriology of Closed Loop, Strangulated Obstruction in Dogs.

1961 ◽  
Vol 41 (3) ◽  
pp. 245-250 ◽  
Author(s):  
George H. Bornside ◽  
Isidore Cohn
Keyword(s):  
Closed Loop
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