Capillary Isoelectric Focusing with UV Fluorescence Imaging Detection Enables Direct Charge Heterogeneity Characterization of Erythropoietin Drug Products

2021 ◽  
pp. 462043
Author(s):  
Xiang Li ◽  
Lei Yu ◽  
Xingchang Shi ◽  
Yong Zhou ◽  
Chunming Rao
Keyword(s):  
Fluorescence Imaging ◽  
Isoelectric Focusing ◽  
Capillary Isoelectric Focusing ◽  
Charge Heterogeneity ◽  
Uv Fluorescence ◽  
Drug Products ◽  
Imaging Detection

Fluorescence imaging detection for capillary isoelectric focusing

1995 ◽  
Vol 16 (1) ◽  
pp. 1474-1478 ◽  
Author(s):  
Xing-Zheng Wu ◽  
Jiaqi Wu ◽  
Janusz Pawliszyn
Keyword(s):  
Fluorescence Imaging ◽  
Isoelectric Focusing ◽  
Capillary Isoelectric Focusing ◽  
Imaging Detection

Capillary isoelectric focusing (CIEF) for the characterization of humic substances

1997 ◽  
Vol 31 (8) ◽  
pp. 2037-2049 ◽  
Author(s):  
Ph. Schmitt ◽  
A.W. Garrison ◽  
D. Freitag ◽  
A. Kettrup
Keyword(s):  
Humic Substances ◽  
Isoelectric Focusing ◽  
Capillary Isoelectric Focusing

An improved capillary isoelectric focusing-mass spectrometry method for high-resolution characterization of monoclonal antibody charge variants

2022 ◽  
Author(s):  
Tian Xu ◽  
Linjie Han ◽  
Alayna M. George Thompson ◽  
Liangliang Sun
Keyword(s):  
Mass Spectrometry ◽  
Monoclonal Antibody ◽  
High Resolution ◽  
Isoelectric Focusing ◽  
Capillary Isoelectric Focusing ◽  
Spectrometry Method ◽  
Mass Spectrometry Method ◽  
Charge Variants

Routine and high-resolution characterization of monoclonal antibody (mAb) charge variants is vital for controlling mAb quality as therapeutics. Capillary isoelectric focusing-mass spectrometry (cIEF-MS) has emerged as a powerful tool for...

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