Prognostic and Therapeutic Implications of Circulating Androgen Receptor Gene Copy Number in Prostate Cancer Patients Using Droplet Digital Polymerase Chain Reaction

2018 ◽  
Vol 16 (3) ◽  
pp. 197-205.e5 ◽  
Author(s):  
Sarah Buelens ◽  
Tom Claeys ◽  
Bert Dhondt ◽  
Filip Poelaert ◽  
Matthijs Vynck ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Copy Number ◽  
Receptor Gene ◽  
Gene Copy Number ◽  
Androgen Receptor Gene ◽  
Gene Copy ◽  
Chain Reaction ◽  
Therapeutic Implications ◽  
Polymerase Chain ◽  
Digital Polymerase Chain Reaction

Androgen Receptor Gene Copy Number and Protein Expression in Treatment-Naïve Prostate Cancer

2017 ◽  
Vol 99 (2) ◽  
pp. 222-228 ◽  
Author(s):  
Filip Poelaert ◽  
Candy Kumps ◽  
Nicolaas Lumen ◽  
Stephanie Verschuere ◽  
Louis Libbrecht ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Androgen Receptor ◽  
Protein Expression ◽  
Copy Number ◽  
Receptor Gene ◽  
Gene Copy Number ◽  
Androgen Receptor Gene ◽  
Gene Copy ◽  
Treatment Naïve

Quantitation of Gene Copy Number and mRNA Using the Polymerase Chain Reaction

1992 ◽  
Vol 200 (1) ◽  
pp. 1-6 ◽  
Author(s):  
M. Volkenandt ◽  
A. P. Dicker ◽  
D. Banerjee ◽  
R. Fanin ◽  
B. Schweitzer ◽  
...  
Keyword(s):  
Polymerase Chain Reaction ◽  
Copy Number ◽  
Gene Copy Number ◽  
Gene Copy ◽  
Chain Reaction ◽  
Polymerase Chain

Increased androgen receptor gene copy number is associated with TMPRSS2-ERG rearrangement in prostatic small cell carcinoma

2014 ◽  
Vol 54 (9) ◽  
pp. 900-907 ◽  
Author(s):  
Lisha Wang ◽  
Sean R. Williamson ◽  
Shaobo Zhang ◽  
Jiaoti Huang ◽  
Rodolfo Montironi ◽  
...  
Keyword(s):  
Androgen Receptor ◽  
Cell Carcinoma ◽  
Small Cell Carcinoma ◽  
Copy Number ◽  
Receptor Gene ◽  
Gene Copy Number ◽  
Androgen Receptor Gene ◽  
Small Cell ◽  
Gene Copy ◽  
Erg Rearrangement

Competitive Polymerase Chain Reaction for the Quantification of N-myc Gene Copy Number in Neuroblastoma

Tumor Biology ◽  
1996 ◽  
Vol 17 (5) ◽  
pp. 262-270 ◽  
Author(s):  
Akira Inoue ◽  
Ziaul Hasan ◽  
Hiromichi Hemmi ◽  
Naotoshi Kanda ◽  
Yasuhide Hayashi ◽  
...  
Keyword(s):  
Polymerase Chain Reaction ◽  
Copy Number ◽  
Gene Copy Number ◽  
Gene Copy ◽  
Chain Reaction ◽  
Competitive Polymerase Chain Reaction ◽  
Polymerase Chain ◽  
I Gene

Determination of CYP2D6 gene copy number by multiplex polymerase chain reaction analysis

2009 ◽  
Vol 389 (1) ◽  
pp. 74-76 ◽  
Author(s):  
Luis J. Leandro-García ◽  
Susanna Leskelä ◽  
Cristina Montero-Conde ◽  
Iñigo Landa ◽  
Elena López-Jimenez ◽  
...  
Keyword(s):  
Polymerase Chain Reaction ◽  
Copy Number ◽  
Multiplex Polymerase Chain Reaction ◽  
Gene Copy Number ◽  
Polymerase Chain Reaction Analysis ◽  
Gene Copy ◽  
Chain Reaction ◽  
Cyp2d6 Gene ◽  
Polymerase Chain

Assessment of pfmdr 1 gene copy number by tandem competitive polymerase chain reaction

1997 ◽  
Vol 85 (2) ◽  
pp. 161-169 ◽  
Author(s):  
Ric Price ◽  
Grant Robinson ◽  
Alan Brockman ◽  
Alan Cowman ◽  
Sanjeev Krishna
Keyword(s):  
Polymerase Chain Reaction ◽  
Copy Number ◽  
Gene Copy Number ◽  
Gene Copy ◽  
Chain Reaction ◽  
Competitive Polymerase Chain Reaction ◽  
Polymerase Chain

scholarly journals Chromosome X aneusomy and androgen receptor gene copy number aberrations in apocrine carcinoma of the breast

2021 ◽  
Author(s):  
Anna Cremonini ◽  
Luca Saragoni ◽  
Luca Morandi ◽  
Angelo G. Corradini ◽  
Caterina Ravaioli ◽  
...  
Keyword(s):  
Androgen Receptor ◽  
Receptor Gene ◽  
Gene Copy Number ◽  
Androgen Receptor Gene ◽  
Gene Copy ◽  
Immunohistochemical Expression ◽  
Neoplastic Cells ◽  
Genetic Changes ◽  
Rare Tumours ◽  
Regulator Genes

AbstractCarcinomas with apocrine differentiation (CAD) of the breast are rare tumours typically presenting high immunohistochemical expression of androgen receptor (AR) which is a target molecule for personalised therapy. To date, no studies have evaluated the genetic changes that are associated with AR immunohistochemical expression in CADs. The present work aims to characterise AR status in CADs. Twenty CAD tumours were studied with immunohistochemistry, in situ fluorescence hybridization and DNA methylation analysis, to evaluate AR expression and its regulator status. All tumours demonstrated high AR immunohistochemical expression, with over 95% of the neoplastic cells showing AR positivity in 19/20 cases. CADs showed AR gene copy loss in a percentage of neoplastic cells ranging from 5 to 84% (mean 48.93%). AR regulator genes, including the MAGE family, UXT and FLNA, presented variable methylation levels, but were mainly hypomethylated and therefore all transcriptionally active. The results of this study indicate that CADs present AR monosomy, paralleled by higher transcriptional activity of the gene with potential to influence response to AR deprivation therapy.

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