scholarly journals Donor-specific elispot assay for predicting acute rejection and allograft function after kidney transplantation: a systematic review and meta-analysis

2021 ◽  
Author(s):  
Suwasin Udomkarnjananun ◽  
Stephen J. Kerr ◽  
Natavudh townamchai ◽  
Nicole M. van Besouw ◽  
Dennis A. Hesselink ◽  
...  
Keyword(s):  
Systematic Review ◽  
Kidney Transplantation ◽  
Acute Rejection ◽  
Elispot Assay ◽  
Meta Analysis ◽  
Allograft Function

scholarly journals The association between vitamin D and acute rejection in human kidney transplantation: A systematic review and meta-analysis study

2021 ◽  
pp. 101410
Author(s):  
Mohammad Mirzakhani ◽  
Sheyda Mohammadkhani ◽  
Shirin Hekmatirad ◽  
Soudabeh Aghapour ◽  
Negar Gorjizadeh ◽  
...  
Keyword(s):  
Systematic Review ◽  
Vitamin D ◽  
Kidney Transplantation ◽  
Acute Rejection ◽  
Meta Analysis ◽  
Human Kidney ◽  
Analysis Study

scholarly journals Comparison of induction therapy with anti-thymocyte/antilymphocyte globulin or anti-IL-2 receptor antibody in pediatric kidney transplantation: a systematic review and meta-analysis

2021 ◽  
Author(s):  
Xiaohong Lin ◽  
Miaohan Deng ◽  
Xitao Hong ◽  
Weiqiang Ju ◽  
Maogen Chen
Keyword(s):  
Systematic Review ◽  
Kidney Transplantation ◽  
Survival Rate ◽  
Acute Rejection ◽  
Confidence Interval ◽  
Induction Therapy ◽  
Meta Analysis ◽  
Rejection Rate ◽  
Antilymphocyte Globulin ◽  
Pediatric Kidney Transplantation

Abstract BackgroundAnti-IL-2 antibody (basiliximab or daclizumab) and anti-thymocyte globulin (ATG)/antilymphocyte globulin (ALG) are widely used as induction agents in pediatric kidney transplantation. However, which of them benefits patients more remains unknown.MethodsOnline databases were searched to identify controlled clinical studies that compared anti-IL-2 with ATG/ALG for induction therapy in pediatric kidney transplantation. Odds ratios (OR) and 95% confidence interval (CI) were chosen to compare the gathered data. Review Manager 5.4 was applied to identify differences in outcomes between the two agents.ResultsFive retrospective cohort studies were included, enrolling a total of 2510 pediatric patients, 1152 (45.7%) of whom had received ATG/ALG therapy and 1370 (54.3%) of whom received anti-IL-2. According to the pooled results, no differences were seen between anti-IL-2 and ATG/ALG regarding the delayed graft function (DGF) rate (odds ratio (OR) 1.1; 95% confidence interval (CI) 0.36–3.39; P = 0.85), 6-month acute rejection rate (OR 0.80; 95% CI 0.62–1.03; P = 0.09), 1-year acute rejection rate (OR 0.98; 95% CI 0.78–1.24; P = 0.88), 1-year graft survival rate (OR 1.37; 95% CI 0.91–2.06; P = 0.13), 1-year patient survival rate (OR 0.86; 95% CI 0.40–1.86; P = 0.70) and 1-year post-transplantation lymphoproliferative disorder (PTLD) rate (OR 0.30; 95% CI 0.03–3.16; P = 0.32).ConclusionsAnti-IL-2 have the same efficacy and safety as ATG/ALG in transplant induction therapy. However, as most of included studies were small-scale retrospective studies, further studies are needed to identify an optimal choice with certain.The analysis had been registered in PROSPERO and the registration ID is CRD42021237561. Comparison of induction therapy with anti-thymocyte/antilymphocyte globulin or anti-IL-2 receptor antibody in pediatric kidney transplantation: a systematic review and meta-analysis

scholarly journals Kidney transplant outcomes in HIV-positive patients: a systematic review and meta-analysis

2019 ◽  
Vol 16 (1) ◽  
Author(s):  
Xin Zheng ◽  
Lian Gong ◽  
Wenrui Xue ◽  
Song Zeng ◽  
Yue Xu ◽  
...  
Keyword(s):  
Systematic Review ◽  
Kidney Transplantation ◽  
Antiretroviral Therapy ◽  
Acute Rejection ◽  
Kidney Transplant ◽  
Graft Survival ◽  
Patient Survival ◽  
Meta Analysis ◽  
Infectious Complications ◽  
Hiv Positive

Abstract Background Kidney transplantation is now a viable alternative to dialysis in HIV-positive patients who achieve good immunovirological control with the currently available antiretroviral therapy regimens. This systematic review and meta-analysis investigate the published evidence of outcome and risk of kidney transplantation in HIV-positive patients following the PRISMA guidelines. Methods Searches of PubMed, the Cochrane Library and EMBASE identified 27 cohort studies and 1670 case series evaluating the survival of HIV-positive kidney transplant patients published between July 2003 and May 2018. The regimens for induction, maintenance therapy and highly active antiretroviral therapy, acute rejection, patient and graft survival, CD4 count and infectious complications were recorded. We evaluated the patient survival and graft survival at 1 and 3 years respectively, acute rejection rate and also other infectious complications by using a random-effects analysis. Results At 1 year, patient survival was 0.97 (95% CI 0.95; 0.98), graft survival was 0.91 (95% CI 0.88; 0.94), acute rejection was 0.33 (95% CI 0.28; 0.38), and infectious complications was 0.41 (95% CI 0.34; 0.50), and at 3 years, patient survival was 0.94 (95% CI 0.90; 0.97) and graft survival was 0.81 (95% CI 0.74; 0.87). Conclusions With careful selection and evaluation, kidney transplantation can be performed with good outcomes in HIV-positive patients.

scholarly journals Soluble CD30, the Immune Response, and Acute Rejection in Human Kidney Transplantation: A Systematic Review and Meta-Analysis

2020 ◽  
Vol 11 ◽  
Author(s):  
Mohammad Mirzakhani ◽  
Mehdi Shahbazi ◽  
Roghayeh Akbari ◽  
Ivana Dedinská ◽  
Eghlim Nemati ◽  
...  
Keyword(s):  
Systematic Review ◽  
Immune Response ◽  
Kidney Transplantation ◽  
Acute Rejection ◽  
Meta Analysis ◽  
Human Kidney ◽  
Soluble Cd30

scholarly journals Effects of renal transplantation on erectile dysfunction: a systematic review and meta-analysis

2021 ◽  
Author(s):  
Irham Arif Rahman ◽  
Nur Rasyid ◽  
Ponco Birowo ◽  
Widi Atmoko
Keyword(s):  
Systematic Review ◽  
Erectile Dysfunction ◽  
Kidney Transplantation ◽  
Renal Transplantation ◽  
End Stage Renal Disease ◽  
Erectile Function ◽  
Meta Analysis ◽  
Post Transplantation ◽  
Stage Renal Disease ◽  
End Stage

AbstractErectile dysfunction (ED) is a major global health burden commonly observed in patients with end-stage renal disease (ESRD). Although renal transplantation improves the problem in some patients, it persists in ≈20–50% of recipients. Studies regarding the effects of kidney transplantation on ED present contradictory findings. We performed a systematic review to summarise the effects of kidney transplantation on ED. A systematic literature search was performed across PubMed, Cochrane, and Scopus databases in April 2020. We included all prospective studies that investigated the pre and posttransplant international index of erectile function (IIEF-5) scores in recipients with ED. Data search in PubMed and Google Scholar produced 1326 articles; eight were systematically reviewed with a total of 448 subjects. Meta-analysis of IIEF-5 scores showed significant improvements between pre and post transplantation. Our findings confirm that renal transplantation improves erectile function. Furthermore, transplantation also increases testosterone level. However, the evidence is limited because of the small number of studies. Further studies are required to investigate the effects of renal transplantation on erectile function.

Sign in / Sign up

Export Citation Format

Share Document