A Comprehensive In Vivo and In Vitro Assessment of the Drug Interaction Potential of Red Ginseng

2018 ◽  
Vol 40 (8) ◽  
pp. 1322-1337 ◽  
Author(s):  
Sook Jin Seong ◽  
Woo Youl Kang ◽  
Jae-Kyung Heo ◽  
Jungjae Jo ◽  
Won Gu Choi ◽  
...  
Keyword(s):  
Drug Interaction ◽  
Interaction Potential ◽  
Red Ginseng ◽  
In Vitro Assessment

scholarly journals CYP3A4 mediated pharmacokinetics drug interaction potential of Maha-Yogaraj Gugglu and E, Z guggulsterone

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Sarvesh Sabarathinam ◽  
Satish Kumar Rajappan Chandra ◽  
Vijayakumar Thangavel Mahalingam
Keyword(s):  
Drug Interaction ◽  
Interaction Potential ◽  
Oral Route ◽  
Sprague Dawley ◽  
Pharmacokinetic Drug Interaction ◽  
Group A ◽  
Clinically Significant ◽  
Group B

AbstractMaha yogaraja guggulu (MYG) is a classical herbomineral polyherbal formulation being widely used since centuries. The aim of this study was to investigate the effect of MYG formulation and its major constituents E & Z guggulsterone on CYP3A4 mediated metabolism. In vitro inhibition of MYG and Guggulsterone isomers on CYP3A4 was evaluated by high throughput fluorometric assay. Eighteen Adult male Sprague–Dawley rats (200 ± 25 g body weight) were randomly divided into three groups. Group A, Group B and Group C were treated with placebo, MYG and Standard E & Z guggulsterone for 14 days respectively by oral route. On 15th day, midazolam (5 mg/kg) was administered orally to all rats in each group. Blood samples (0.3 mL) were collected from the retro orbital vein at 0.25, 0.5, 0.75, 1, 2, 4, 6, 12 and 24 h of each rat were collected. The findings from the in vitro & in vivo study proposed that the MYG tablets and its guggulsterone isomers have drug interaction potential when consumed along with conventional drugs which are CYP3A4 substrates. In vivo pharmacokinetic drug interaction study of midazolam pointed out that the MYG tablets and guggulsterone isomers showed an inhibitory activity towards CYP3A4 which may have leads to clinically significant interactions.

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