Structured triglycerides versus physical mixtures of medium- and long-chain triglycerides for parenteral nutrition in surgical or critically ill adult patients: Systematic review and meta-analysis

Introduction The choice of intravenous fluid for fluid therapy in critically ill adult patients remains a matter of debate. Currently, crystalloids are used more often than colloids, with ongoing controversy over the relative efficacy and safety of buffered salt solutions (BSS) versus normal saline (0.9% sodium chloride). In 2021 two large pragmatic trials enrolling critically ill patients will add substantial new data to address this controversy. We will conduct a systematic review and meta-analysis of randomised controlled trials (RCTs) that will include the data from these two trials to provide clinicians with the most up to date evidence and robust evidence to guide their choice of crystalloid fluids. Methods and analysis We will include RCTs that compare the effect of buffered salt solutions to normal saline for fluid resuscitation and/or fluid therapy in critically ill adults, on all-cause mortality and other patient centred outcomes. We will perform a search that includes the electronic databases MEDLINE and EMBASE, and clinical trial registries. Two reviewers will independently screen titles and abstracts, perform full article reviews and extract study data, with discrepancies resolved by a third reviewer. We will report study characteristics and assess risk of bias using the Cochrane Risk-of-Bias tool. We will perform Hartung-Knapp-Sidik-Jonkman random-effects aggregate data meta-analysis whenever it is feasible to do so. We will evaluate overall certainty of evidence using the Grading of Recommendations Assessment, Development, and Evaluation (GRADE) framework. Ethics and dissemination This systematic review and meta-analysis does not require ethical approval as it does not involve primary data collection. We will publish our results in a peer-reviewed scientific journal and present them at national and international scientific conferences. PROSPERO registration number: CRD42021243399

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Diagnostic value of procalcitonin and presepsin for sepsis in critically ill adult patients: a systematic review and meta-analysis

Journal of Intensive Care ◽

10.1186/s40560-019-0374-4 ◽

2019 ◽

Vol 7 (1) ◽

Cited By ~ 18

Author(s):

Yutaka Kondo ◽

Yutaka Umemura ◽

Kei Hayashida ◽

Yoshitaka Hara ◽

Morio Aihara ◽

...

Keyword(s):

Systematic Review ◽

Critically Ill ◽

Meta Analysis ◽

Diagnostic Value ◽

Adult Patients

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Faculty Opinions recommendation of Enteral versus parenteral nutrition in critically ill patients: an updated systematic review and meta-analysis of randomized controlled trials.

Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature ◽

10.3410/f.726323313.793523607 ◽

2016 ◽

Author(s):

Bruce Bistrian

Keyword(s):

Systematic Review ◽

Parenteral Nutrition ◽

Randomized Controlled Trials ◽

Critically Ill ◽

Critically Ill Patients ◽

Meta Analysis ◽

Controlled Trials ◽

Randomized Controlled

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Use of weaning protocols for reducing duration of mechanical ventilation in critically ill adult patients: Cochrane systematic review and meta-analysis

BMJ ◽

10.1136/bmj.c7237 ◽

2011 ◽

Vol 342 (jan13 2) ◽

pp. c7237-c7237 ◽

Cited By ~ 118

Author(s):

B. Blackwood ◽

F. Alderdice ◽

K. Burns ◽

C. Cardwell ◽

G. Lavery ◽

...

Keyword(s):

Systematic Review ◽

Mechanical Ventilation ◽

Critically Ill ◽

Meta Analysis ◽

Adult Patients ◽

Cochrane Systematic Review ◽

Weaning Protocols

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Prognostic accuracy of different disseminated intravascular coagulation criteria in critically ill adult patients: a protocol for a systematic review and meta-analysis

BMJ Open ◽

10.1136/bmjopen-2018-024878 ◽

2018 ◽

Vol 8 (12) ◽

pp. e024878

Author(s):

Jumpei Yoshimura ◽

Kazuma Yamakawa ◽

Akira Kodate ◽

Mari Kodate ◽

Satoshi Fujimi

Keyword(s):

Systematic Review ◽

Diagnostic Accuracy ◽

Critically Ill ◽

Disseminated Intravascular Coagulation ◽

Scoring System ◽

Meta Analysis ◽

Adult Patients ◽

Intravascular Coagulation ◽

Operating Points ◽

Receiver Operating

IntroductionDisseminated intravascular coagulation (DIC) is a common and serious condition that can lead to poor outcomes in critically ill patients. To make a correct diagnosis and improve the outcome of patients with DIC, several organisations have put forward DIC scoring systems. However, which criteria is the best to use for diagnosing DIC remains a continuing controversy even though many studies have been conducted to validate the diagnostic accuracy of each DIC scoring system.Methods and analysisWe will conduct a systematic review and meta-analysis of the diagnostic accuracy of DIC criteria for the prediction of mortality in critically ill adult patients. The primary objective is to assess the predictive values of the DIC criteria of Japanese Association for Acute Medicine, International Society on Thrombosis and Haemostasis, Japanese Ministry of Health and Welfare, Korean Society on Thrombosis and Hemostasis and Chinese Diagnostic Scoring System for 28-day mortality. We will search electronic bibliographic databases such as MEDLINE, EMBASE and Cochrane Central Register of Controlled Trials. Two reviewers will independently screen titles and abstracts, perform full article reviews and extract study data. We will report study characteristics and assess methodological quality using the Quality of Diagnostic Accuracy Studies-II tool. If pooling is appropriate, we will compute parameter estimates using bivariate random-effects and hierarchical summary receiver operating characteristic models to produce summary receiver operating curves, summary operating points (pooled sensitivity and specificity) and 95% confidence regions around the summary operating points. Clinical and methodological subgroup and sensitivity analyses will be performed to explore heterogeneity.Ethics and disseminationThis systematic review will help physicians diagnose DIC accurately and improve their clinical practice in critically ill settings. Approval from an ethics committee is not required. The findings will be disseminated through publication in a peer-reviewed journal.PROSPERO registration numberCRD42017079350.

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